Hemodynamic Instability during Acute Kidney Injury and Acute Renal Replacement Therapy: Pathophysiology and Clinical Implications
Hemodynamic instability associated with acute renal replacement therapy (aRRT, HIRRT) and/or with acute kidney injury (AKI) is frequently observed in the intensive care unit; it affects patients ’ renal recovery, and negatively impacts short- and long-term mortality. A thorough understanding of mechanisms underlying HIRRT and AKI-related hemodynamic instability may allow the physician in adopting adequate strategies to prevent their occurrence and reduce their negative consequences. The a im of this review is to summarize the main alterations occurring in patients with AKI and/or requiring aRRT of those homeostatic mecha...
Source: Blood Purification - March 23, 2021 Category: Hematology Source Type: research
Neutrophil Gelatinase-Associated Lipocalin for the Assessment of Reversible versus Persistent Renal Tubular Damage in ST-Segment Myocardial Infarction Patients
Conclusions: Renal tubular damage is common among STEMI patients. Dynamic NGAL measurement may differentiate between reversible and persistent tubular damage. Further trials are needed in order to assess the complex cardiorenal interactions.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 23, 2021 Category: Hematology Source Type: research
COVID-19 in Chronic Kidney Disease: The Impact of Old and Novel Cardiovascular Risk Factors
Cardiovascular disease is a frequent complication and the most common cause of death in patients with CKD. Despite landmark medical advancements, mortality due to cardiovascular disease is still 20 times higher in CKD patients than in the general population, which is mainly due to the high prevalence of risk factors in this group. Indeed, in addition to traditional cardiovascular risk factors, CKD patients are exposed to nontraditional ones, which include metabolic, hormonal, and inflammatory alterations. The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought novel challenges for both ...
Source: Blood Purification - March 22, 2021 Category: Hematology Source Type: research
The Impact of Old and Novel Cardiovascular Risk Factors
Cardiovascular disease is a frequent complication and the most common cause of death in patients with CKD. Despite landmark medical advancements, mortality due to cardiovascular disease is still 20 times higher in CKD patients than in the general population, which is mainly due to the high prevalence of risk factors in this group. Indeed, in addition to traditional cardiovascular risk factors, CKD patients are exposed to nontraditional ones, which include metabolic, hormonal, and inflammatory alterations. The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought novel challenges for both ...
Source: Blood Purification - March 22, 2021 Category: Hematology Source Type: research
Community- and Hospital-Acquired Acute Kidney Injury in COVID-19: Different Phenotypes and Dismal Prognosis
Conclusions: CA-AKI and HA-AKI portend an adverse prognosis in CO VID-19. Nevertheless, CA-AKI was associated with a higher comorbidity burden (including CKD and hypertension), while HA-AKI occurred in younger patients by the time severe multiorgan disease developed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 19, 2021 Category: Hematology Source Type: research
Serum Uric Acid and Mortality in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Conclusions: Higher and lower SUA levels are both associated with significantly increased risk of all-cause mortality in patients with CKD. A appreciate dose of treatment of lowering SUA agents should be confirmed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 19, 2021 Category: Hematology Source Type: research
A Scoring Model with Simple Clinical Parameters to Predict Successful Discontinuation of Continuous Renal Replacement Therapy
Conclusions: Scoring system composed of urine output ≥300 mL/day on D-1, and adequate blood pressure, serum potassium #x3c;4.1 mmol/L, and BUN #x3c;35 mg/dL (12.5 mmol/L) on D0 was developed to predict successful discontinuation of CRRT.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 18, 2021 Category: Hematology Source Type: research
Association between Procalcitonin and Acute Kidney Injury in Patients with Bacterial Septic Shock
Conclusions: Our data revealed a nonlinear relationship between PCT and AKI in septic shock patients, and PCT could be used as a potential biomarker of AKI in female patients younger than 75 years with bacterial septic shock.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 17, 2021 Category: Hematology Source Type: research
New Therapeutic Approach to Reduce Methotrexate Toxicity after High-Dose Chemotherapy in a Child with Acute Lymphocytic Leukemia: Efficacy and Safety of Hemoadsorption with HA-230 Adsorber
Conclusion: Based on our results, single-hemoadsorption procedure with the HA-230 adsorber in case of delayed methotrexate clearance was safe and well-tolerated in a pediatric patient with ALL and would significantly improve the patient ’s condition. Further studies need to demonstrate its safety and efficacy in a large number of pediatric patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 16, 2021 Category: Hematology Source Type: research
Sudden Cardiac Death, Haemodialysis, Hydroxychloroquine, and COVID-19
Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 16, 2021 Category: Hematology Source Type: research
Should the Therapeutic Apheresis Method Be Added to Treatment in the COVID-19 Outbreak?
Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 15, 2021 Category: Hematology Source Type: research
An Interdisciplinary Approach to Optimize the Care of Transitioning Adolescents and Young Adults with CKD
Adolescents and young adults (AYAs) with CKD or end-stage kidney disease (ESKD) have unique medical, dental, psychosocial, neurocognitive, and academic needs and require close interdisciplinary collaboration to optimize their care. The etiology of CKD in AYAs is diverse compared to older adults. With their continuously improved survival, AYAs must start preparation for health-care transition (HCT) from pediatric- to adult-focused health care in the pediatric setting and it must continue at the adult-focused setting, given that their brain maturation and self-management skill acquisition occur until their mid-20s. While the...
Source: Blood Purification - March 11, 2021 Category: Hematology Source Type: research
Improved Formula for Predicting Hemodialyzability of Intravenous and Oral Drugs
Conclusion: The modified equation derived in this study using pharmacokinetic and physical parameters as variables precisely predicted the removal rates of both intravenous and oral drugs by hemodialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 9, 2021 Category: Hematology Source Type: research
Safety Management of Dialysis Fluid in Japan: Important Duties and Responsibilities of Clinical Engineers
Dialysis therapy is the predominant choice for renal failure in Japan, and almost 30% of the patients with renal failure have been treated for 10 years or more. Dialysis became the standard procedure to treat renal failure nationwide in the 1980s. However, at that time, managing the increased number of patients on maintenance hemodialysis as well as operating and maintaining the newly developed advanced medical technologies at extensive numbers of clinical sites proved problematic. To help address this, the clinical engineer system was established in 1987 and certain aspects of the clinical engineers ’ role remain unique...
Source: Blood Purification - March 8, 2021 Category: Hematology Source Type: research
The 2020 Updated KDOQI Clinical Practice Guidelines for Nutrition in Chronic Kidney Disease
Over the last 2 decades, there has been a great accumulation of new evidence regarding the management of nutritional and metabolic aspects of kidney disease. The 2020 update to the KDOQI Clinical Practice Guideline for Nutrition in CKD provides a comprehensive up-to-date information on the understanding and care of patients with CKD. It provides updated information on nutritional aspects of kidney disease for the practicing clinician and allied health-care workers. The current manuscript provides an overview of the updated guideline statements on major subjects including nutritional assessment, dietary protein and energy i...
Source: Blood Purification - March 2, 2021 Category: Hematology Source Type: research
