Hypericum perforatum L.: a medicinal plant with potential as a curative agent against obesity-associated complications.
In this study, 3T3-L1 adipocytes were used to mimic the adipocyte differentiation associated with obesity in cellular terms. Lipoprotein lipase (Lpl), Diacylglycerol-O-acyltransferase 1 (Dgat1), Fatty acid synthase (Fasn) markers were used to study the lipid accumulation, and Collagen V (ColV) was used to study cell elasticity to investigate the relationship of the effects of the administration of Hypericum perforatum L. with obesity. PMID: 33090307 [PubMed - as supplied by publisher] (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - October 22, 2020 Category: Molecular Biology Authors: Tokgöz HB, Altan F Tags: Mol Biol Rep Source Type: research

Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin ( Hypericum perforatum ) photosensitizer: in vitro study
AbstractAcne vulgaris is the most recurring skin condition in the world, causing great harm to the physical and psychological well-being of many patients. Antimicrobial photodynamic therapy (aPDT) has broad therapeutic applicability. The purpose was to evaluate in vitro the photodynamic inactivation againstPropionibacterium acnes (P. acnes) biofilms by using different concentrations of hypericin (Hypericum perforatum) photosensitizer associated with different energies of low-level laser. The biofilms were placed in 96-well microplates with a 6.4-mm diameter surface, by using standard suspensions (2  × 1...
Source: Lasers in Medical Science - October 21, 2020 Category: Laser Surgery Source Type: research

Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway.
In conclusion, our findings provided evidence that develops Astilbin as a potential therapeutic drug for OA patients. PMID: 33063931 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)
Source: J Cell Mol Med - October 16, 2020 Category: Molecular Biology Authors: Sun S, Yan Z, Shui X, Qi W, Chen Y, Xu X, Hu Y, Guo W, Shang P Tags: J Cell Mol Med Source Type: research

Genes, Vol. 11, Pages 1210: The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum Perforatum L., One of the Largest Medicinal Crops in Europe
D’Auria Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activ...
Source: Genes - October 16, 2020 Category: Genetics & Stem Cells Authors: Rizzo Altschmied Ravindran Rutten D ’Auria Tags: Review Source Type: research

Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them.
CONCLUSIONS: We identified no studies for inclusion in this review. This is not surprising given the relatively recent emergence of COVID-19 infection. It is promising that the question posed in this review is being addressed by a number of RCTs and other studies. We are concerned that few of the ongoing studies specifically state that they will evaluate adverse events such as changes in the sense of smell or to the oral and nasal microbiota, and any consequences thereof. Very few interventions have large and dramatic effect sizes. If a positive treatment effect is demonstrated when studies are available for...
Source: Cochrane Database of Systematic Reviews - September 15, 2020 Category: General Medicine Authors: Burton MJ, Clarkson JE, Goulao B, Glenny AM, McBain AJ, Schilder AG, Webster KE, Worthington HV Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 25, Pages 4256: Optimization of Light Intensity, Temperature, and Nutrients to Enhance the Bioactive Content of Hyperforin and Rutin in St. John ’s Wort
Molecules, Vol. 25, Pages 4256: Optimization of Light Intensity, Temperature, and Nutrients to Enhance the Bioactive Content of Hyperforin and Rutin in St. John’s Wort Molecules doi: 10.3390/molecules25184256 Authors: Chia-Hung Kuo Yi-Chin Chou Kuo-Chun Liao Chwen-Jen Shieh Tzu-Shing Deng St. John’s wort (Hypericum perforatum L.) is a medicinal plant that alleviates depression and other disorders due to its abundance of active ingredients. Hyperforin, rutin, and melatonin are the main active, and important, ingredients in St. John’s wort that alleviate depression. In order ...
Source: Molecules - September 15, 2020 Category: Chemistry Authors: Chia-Hung Kuo Yi-Chin Chou Kuo-Chun Liao Chwen-Jen Shieh Tzu-Shing Deng Tags: Article Source Type: research

How does scientific information reach the consumer? A case study among students into providing verbal information on dietary supplements at point of purchase.
Authors: Lenssen KGM, Bast A, de Boer A Abstract Consumers of dietary supplements should be made aware of the benefits and risks of these products. This case study therefore aimed to identify the content of the risk-benefit information provided during the purchase of St. John's wort supplements and how consumers perceive this information. Fifteen participants visited a shop to purchase St. John's wort supplements after which they were interviewed on the provided information during the visit. This case study shows that the spontaneous information provision is not consistent in Dutch drugstores and health food shops....
Source: International Journal of Food Sciences and Nutrition - September 13, 2020 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

Elucidation the binding interaction of hypericin-loaded P84 copolymeric micelles by using 1D and 2D NMR techniques.
ano W Abstract Hypericin (HYP) is an active compound of Hypericum perforatum. Associated with photodynamic therapy (PDT), HYP has shown a broad therapeutic potential against microorganisms and cancer cells. Due to the low water solubility of HYP, its application in the biological medium becomes limited. To solve this limitation, our research group has been used copolymeric micelles to carrier HYP with high efficiency. However, there is no elucidated mechanism for HYP delivery mediated by copolymeric micelles. In this sense, we believed that the study of binding-sites of copolymeric micelles and HYP is the first st...
Source: Natural Product Research - September 10, 2020 Category: Biochemistry Authors: Gonçalves RS, de Oliveira ACV, Hioka N, Caetano W Tags: Nat Prod Res Source Type: research

Molecules, Vol. 25, Pages 3964: MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of Hypericum Species
llárová Souvik Kusari Hypericum perforatum and related species (Hypericaceae) are a reservoir of pharmacologically important secondary metabolites, including the well-known naphthodianthrone hypericin. However, the exact biosynthetic steps in the hypericin biosynthetic pathway, vis-à-vis the essential precursors and their localization in plants, remain unestablished. Recently, we proposed a novel biosynthetic pathway of hypericin, not through emodin and emodin anthrone, but skyrin. However, the localization of skyrin and its precursors in Hypericum plants, as well as the correlation betwe...
Source: Molecules - August 30, 2020 Category: Chemistry Authors: Bharadwaj Revuru Miroslava B álintová Jana Henzelyov á Eva Čellárová Souvik Kusari Tags: Article Source Type: research

To Be Continued? Long-Term Treatment Effects of Antidepressant Drug Classes and Individual Antidepressants on the Risk of Developing Dementia: A German Case-Control Study.
CONCLUSIONS: Long-term treatment with tricyclic antidepressants, Hypericum perforatum, or escitalopram may be associated with reduced incidence of dementia. If antidepressant therapy is well tolerated, continuation-even if depressive symptoms have resolved-may be considered even beyond the purpose of relapse prevention. Future combined analyses of multinational registries and long-term clinical trials are needed to substantiate these findings. PMID: 32857931 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

[ASAP] Hyperfols A and B: Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from < italic toggle="yes" > Hypericum perforatum < /italic >
Organic LettersDOI: 10.1021/acs.orglett.0c02434 (Source: Organic Letters)
Source: Organic Letters - August 21, 2020 Category: Chemistry Authors: Hua-Yong Lou †‡∥, Ya-Nan Li†‡∥, Ping Yi†‡, Jun-You Jian†‡, Zhan-Xing Hu†‡, Wei Gu†‡, Lie-Jun Huang†‡, Yan-Mei Li†‡, Chun-Mao Yuan*†‡, and Xiao-Jiang Hao*†‡§ Source Type: research

Pharmacological and genetic inhibition of TRPC6-induced gene transcription.
In this study it is shown that both compounds, in addition to inhibiting TRPC6-induced signaling, completely abolished pregnenolone sulfate-mediated signaling via TRPM3 channels. Thus, SAR 7334 and larixyl acetate are not TRPC6-specific inhibitors. PMID: 32758574 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - August 2, 2020 Category: Drugs & Pharmacology Authors: Scheuble J, Rössler OG, Ulrich M, Thiel G Tags: Eur J Pharmacol Source Type: research

Hypericum scruglii Bacchetta, Brullo & Salmeri, is it a possible natural resource against Fibromyalgia?
Fibromyalgia (FM) is today a serious public health issue. Tested treatments have shown limited efficacy.Oxidative stress  probably interacting with the glutamatergic /gamma -Aminobutyric acid balance may play a role.Antidepressants improve sleep and mood especially those with double action on serotonin and norepinephrine, but these are also those with a greater risk of manic switch considering the high frequency of comorbidity with bipolar disorders.This narrative review tries to evaluate, on the basis of in vitro and animal studies, the potential utility in fibromyalgia of Hypericum Scruglii, an endemic species pecul...
Source: International Journal of Phytomedicine - July 20, 2020 Category: Science Authors: Mauro Giovanni Carta Source Type: research

Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3 β Signaling Pathway In Vivo and In Vitro
In conclusion, the present study demonstrated that hyperoside could protect against oxidative stress-induced liver injury by regulating the PHLPP2-AKT-GSK-3β signaling pathway in vivo and in vitro. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

New cytotoxic secondary metabolites against human pancreatic cancer cells from the Hypericum perforatum endophytic fungus Aspergillus terreus.
Abstract Four new compounds, including two lovastatin analogues, terrstatins A and B (1 and 2), and a pair of butenolide derivatives, (±)-asperteretone F (3a/3b), along with eleven known compounds (4-14), were isolated from the Hypericum perforatum endophytic fungus Aspergillus terreus. Their structures and absolute configurations were determined based on extensive spectroscopic analysis, experimental and calculated electronic circular dichroism (ECD) analysis. All isolates were evaluated for cytotoxic activities against five human cancer cell lines, and compounds 3a/3b and 6 showed potential cytotoxic acti...
Source: Fitoterapia - July 12, 2020 Category: Biochemistry Authors: Deng M, Tao L, Qiao Y, Sun W, Xie S, Shi Z, Qi C, Zhang Y Tags: Fitoterapia Source Type: research

Traditional Use of Medicinal Plants in South-Eastern Serbia (P činja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data
This study aimed to collect and document data on the traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is among the least developed regions in Serbia. Also, comparison with data collected by Dr. Jovan Tucakov, in a book called Herbal therapy was conducted. The survey was carried out using semi-structured interviews and 113 informants were interviewed. Quantitative ethnobotany factors were calculated, allowing us discussing the results. The informants reported data on 86 medicinal plants belonging to 43 families in Pčinja district. Lamiaceae, Asteraceae, and Rosaceae were the dominant l...
Source: Frontiers in Pharmacology - July 7, 2020 Category: Drugs & Pharmacology Source Type: research

Identifying Herbal Adverse Events From Spontaneous Reporting Systems Using Taxonomic Name Resolution Approach.
This study aimed to extract, standardize, and summarize supplement-relevant reports from two SRSs: (1) Food and Drug Administration Adverse Event Reporting System (FAERS) and (2) Canada Vigilance Adverse Reaction (CVAR) database. A thesaurus of plant names was developed and integrated with a mapping and normalization approach that accommodated misspellings and variants. The reports gathered from FAERS between the years 2004 and 2016 show 185,915 herbal and 7,235,330 non-herbal accounting for 2.51%. The data from CVAR found 36,940 reports of herbal and 503,580 non-herbal reports between the years 1965 and 2017 for a total o...
Source: Bioinformatics and Biology Insights - July 1, 2020 Category: Bioinformatics Authors: Sharma V, Gelin LFF, Sarkar IN Tags: Bioinform Biol Insights Source Type: research

Hypericum scruglii Bacchetta, Brullo & amp; Salmeri, is it a possible natural resource against Fibromyalgia?
Fibromyalgia (FM) is today a serious public health issue. Tested treatments have shown limited efficacy.Oxidative stress  probably interacting with the glutamatergic /gamma -Aminobutyric acid balance may play a role.Antidepressants improve sleep and mood especially those with double action on serotonin and norepinephrine, but these are also those with a greater risk of manic switch considering the high frequency of comorbidity with bipolar disorders.This narrative review tries to evaluate, on the basis of in vitro and animal studies, the potential utility in fibromyalgia of Hypericum Scruglii, an endemic species pecul...
Source: International Journal of Phytomedicine - June 23, 2020 Category: Science Authors: Mauro Giovanni Carta Source Type: research

A new modulated crystal structure of the ANS complex of the St John's wort Hyp-1 protein with 36 protein molecules in the asymmetric unit of the supercell
Superstructure modulation, with violation of the strict short-range periodic order of consecutive crystal unit cells, is well known in small-molecule crystallography but is rarely reported for macromolecular crystals. To date, one modulated macromolecular crystal structure has been successfully determined and refined for a pathogenesis-related class 10 protein from Hypericum perforatum (Hyp-1) crystallized as a complex with 8-anilinonaphthalene-1-sulfonate (ANS) [Sliwiak et al. (2015), Acta Cryst. D71, 829 – 843]. The commensurate modulation in that case was interpreted in a supercell with sevenfold expansion along c...
Source: Acta Crystallographica Section D - June 16, 2020 Category: Biochemistry Authors: Smietanska, J. Sliwiak, J. Gilski, M. Dauter, Z. Strzalka, R. Wolny, J. Jaskolski, M. Tags: superstructure modulation Hypericum perforatum Hyp-1 research papers Source Type: research

The healing effects of Hyperium perforatum (St. John's Wort) on experimental alkaline corrosive eosephageal and stomach burns.
CONCLUSION: SJW substrate is effective in protecting the esophagus and stomach in mild to moderate alcali corrosive burns in the subacute period. We should keep in mind the protective effects of STW substrate in alkaline corrosive burns of the gastrointestinal system. PMID: 32436985 [PubMed - in process] (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - April 30, 2020 Category: Emergency Medicine Authors: Güvenç E, Kıyan S, Uyanıkgil Y, Çetin EÖ, Karabey F, Çavuşoğlu T, Gökçe B Tags: Ulus Travma Acil Cerrahi Derg Source Type: research

Antidepressants for smoking cessation.
CONCLUSIONS: There is high-certainty evidence that bupropion can aid long-term smoking cessation. However, bupropion also increases the number of adverse events, including psychiatric AEs, and there is high-certainty evidence that people taking bupropion are more likely to discontinue treatment compared with placebo. However, there is no clear evidence to suggest whether people taking bupropion experience more or fewer SAEs than those taking placebo (moderate certainty). Nortriptyline also appears to have a beneficial effect on smoking quit rates relative to placebo. Evidence suggests that bupropion may be as successful as...
Source: Cochrane Database of Systematic Reviews - April 21, 2020 Category: General Medicine Authors: Howes S, Hartmann-Boyce J, Livingstone-Banks J, Hong B, Lindson N Tags: Cochrane Database Syst Rev Source Type: research

Isolation, Characterization and Targeted Metabolic Evaluation of Endophytic Fungi Harbored in 14 Seed-Derived Hypericum Species
Planta Med DOI: 10.1055/a-1130-4703Medicinal plants of the genus Hypericum are rich sources of bioactive naphthodianthrones, which are unique in the plant kingdom, but quite common in fungal endophytes. Cultivable endophytic fungi were isolated from 14 different Hypericum spp. originating from seeds grown under in vitro conditions and further acclimated to outdoor conditions. Among 37 fungal isolates yielded from the aerial and underground plant organs, 25 were identified at the species level by the fungal barcode marker internal transcribed spacer rDNA and protein-coding gene region of tef1α. Ten of them were isolat...
Source: Planta Medica - April 14, 2020 Category: Drugs & Pharmacology Authors: Henzelyov á, Jana Antalov á, Michaela Nigutov á, Katarína Logoida, Mariia Schreiberov á, Andrea Kusari, Souvik Čellárová, Eva Tags: Original Papers Source Type: research

From St. John's wort to tomato and from Rhodiola to cranberry : A  review of phytotherapy and some examples.
CONCLUSION: The findings were diverse and must be individually taken into account. Evidence for efficacy varies within and between the four examples. An explanation for the lack of reproducibility of findings from preclinical and clinical experiments might be the insufficient standardization of herbal medicines. There is no scientific reason why phytotherapy should not be investigated with the same rigor as conventional drugs to establish the efficacy and potential risks. Meanwhile, it is concluded that care is essential when using herbal medicine in the daily routine and informing patients about potential shortcomings and...
Source: Wiener Klinische Wochenschrift - March 23, 2020 Category: General Medicine Authors: Weixlbaumer V, Draxler L, Zeitlinger M, Prantl B Tags: Wien Klin Wochenschr Source Type: research

Polycyclic polyprenylated acylphloroglucinols with acetylcholinesterase inhibitory activities from Hypericum perforatum.
Abstract Six new polycyclic polyprenylated acylphloroglucinols, hyperfols CH (1-6), along with seven known ones (7-13), were isolated from the aerial parts of Hypericum perforatum. The structures were identified on the basis of comprehensive spectroscopic data analysis including 1D and 2D NMR, and the absolute configurations of the new compounds were determined by quantum chemical electronic circular dichroism (ECD) calculations. In addition, compounds 4 and 12 exhibited moderate acetylcholinesterase (AChE) inhibitory activities, with IC50 values of 20.32 and 27.37 μM, respectively. PMID: 32173424 [PubMe...
Source: Fitoterapia - March 11, 2020 Category: Biochemistry Authors: Lou H, Yi P, Hu Z, Li Y, Zeng Y, Gu W, Huang L, Yuan C, Hao X Tags: Fitoterapia Source Type: research

Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats.
Authors: Seyhan N Abstract Background: For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (HP) on second-degree burn wounds in rats. Results: All histological parameters of the control group...
Source: Evidence-based Complementary and Alternative Medicine - March 11, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Molecules, Vol. 25, Pages 1202: Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey
Tepe Tomczyk Phenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that regular consumption of these compounds could have a positive effect on our health. The aim of this study was to compare the phytochemical contents of the water extracts from three different plants used as folk remedies in Turkey: Aesculus hippocastanum, Olea europaea, and Hypericum perforatum. A liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) analysis was performed to explore the phenolic profiles. The biological activities of these extracts...
Source: Molecules - March 5, 2020 Category: Chemistry Authors: Sarikurkcu Locatelli Tartaglia Ferrone Juszczak Ozer Tepe Tomczyk Tags: Article Source Type: research

Photodynamic action of Hypericum perforatum hydrophilic extract against Staphylococcus aureus
Photochem. Photobiol. Sci., 2020, Accepted Manuscript DOI: 10.1039/C9PP00428A, PaperPietro Delcanale, Cormac Hally, Santi Nonell, Silvia Bonardi, Cristiano Viappiani, Stefania Abbruzzetti Hypericin (Hyp) is one of the most effective, naturally occurring photodynamic agents, which proved effective against a wide array of microorganisms. One limitation of its large scale application as a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)
Source: RSC - Photochem. Photobiol. Sci. latest articles - March 5, 2020 Category: Chemistry Authors: Pietro Delcanale Source Type: research

Ethnopharmacology of Hypericum species in China: A comprehensive review on ethnobotany, phytochemistry and pharmacology
ConclusionsThere is a rich traditional knowledge regarding the ethnomedicinal uses of Hypericum species in China. Through phytochemical and pharmacological studies, several medicinal Hypericum from China have yielded many bioactive phytochemicals, possessing antitumor, anti-inflammatory, antimicrobial, and neuroprotective properties. Hypericum species from China are potential sources of drugs to fight cancer and other chronic diseases. Remarkably, nearly half of Hypericum species in China have rarely been studied, and their ethnomedicinal potential have not been scientifically evaluated. Thus, in vitro mechanistic studies,...
Source: Journal of Ethnopharmacology - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Kinetics and Thermodynamics Evaluation of Oxidative Stability in Oleum hyperici: A comparative Study
In this study, Oleum hyperici (St. John's Wort oil) was investigated according to its oxidative stability and antioxidant activity parameters. A homemade and two different brands of oils were used for comparative reasons. Oxidation process regarding kinetics and thermodynamics studies achieved by accelerated Rancimat conditions (100-140 °C). The quality parameters of the oil samples were compared depending on phenolic and flavonoid contents, antioxidant activity, free fatty acid quantity and shelf-life. Principal component analysis (PCA) has been also applied to comprehend the relationship between these three gr...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of St. John's wort (Hypericum perforatum L.) and the impact of filtration process on bioactive extracts incorporated into carbohydrate-based hydrogels
Publication date: Available online 6 February 2020Source: Food HydrocolloidsAuthor(s): Maciej Jarzębski, Wojciech Smułek, Hanna Maria Baranowska, Łukasz Masewicz, Joanna Kobus-Cisowska, Marta Ligaj, Ewa KaczorekAbstractHypericum perforatum L. (HPL) is also called as St. John's wort and is traditionally used as a herbal tea and food supplement because of its excellent bioactive properties. One of the main objective of the present study was to investigate the effect of an additional filtration process on the properties of final HPL extract. Physicochemical studies of crude and filtrate extracts were performed by Fourier-t...
Source: Food Hydrocolloids - February 6, 2020 Category: Food Science Source Type: research

Improve cognition of depressive patients through the regulation of basal ganglia connectivity: Combined medication using Shuganjieyu capsule
Publication date: Available online 28 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Sha Liu, Wentao Zhao, Yaojun Li, Xinrong Li, Jing Li, Hongbao Cao, Zhi Yang, Yong XuAbstractShuganjieyu capsule (Shugan) is a combined extract of Hypericum perforatum (HP) and Eleutherococcus senticosus (ES). Both HP and ES have been proven effective in the treatment of depression and impaired cognition. However, for mild to moderate depression (MMD), the treatment effect and underlying mechanism by combining both HP and ES are largely unknown. Here, we aim to evaluate the therapeutic effects on impaired cognition using Shug...
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo
In this study, we aimed to explore the preventive and therapeutic effects of HP against NAFLD and the underlying mechanisms in vitro and in vivo. Here, we demonstrated that HP improved cell viability by reducing apoptosis and attenuated lipid accumulation in hepatocytes both in vitro and in vivo via attenuating oxidative stress, inhibiting lipogenesis and enhancing lipid oxidization. Thus, HP exhibited significant preventive and therapeutic effects against HFHS-induced NAFLD and dyslipidemia in mice. Furthermore, we demonstrated that HP directly bound to PKACα and activated PKA/AMPK signaling to elicit its effects ag...
Source: Pharmacological Research - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

Hypericibacter terrae gen. nov., sp. nov. and Hypericibacter adhaerens sp. nov., two new members of the family Rhodospirillaceae isolated from the rhizosphere of Hypericum perforatum.
n J Abstract Two strains of the family Rhodospirillaceae were isolated from the rhizosphere of the medicinal plant Hypericum perforatum. Cells of both strains were Gram-stain-negative, motile by means of a single polar flagellum, non-spore-forming, non-capsulated, short rods that divided by binary fission. Colonies were small and white. Strains R5913T and R5959T were oxidase-positive, mesophilic, neutrophilic and grew optimally without NaCl. Both grew under aerobic and microaerophilic conditions and on a limited range of substrates with best results on yeast extract. Major fatty acids were C19 : 0 cyclo &omega...
Source: International Journal of Systematic and Evolutionary Microbiology - January 19, 2020 Category: Microbiology Authors: Noviana Z, Vieira S, Pascual J, Fobofou SAT, Rohde M, Spröer C, Bunk B, Overmann J Tags: Int J Syst Evol Microbiol Source Type: research

Hyperoside exhibits anticancer activity in non ‑small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1.
In conclusion, hyperoside inhibited proliferation and induced apoptosis by upregulating FoxO1 via CCAT1 in T790M‑positive NSCLC both in vitro and in vivo, suggesting that hyperoside is a novel candidate for T790M‑positive NSCLC treatment. PMID: 31894285 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 4, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combined effect of elevated CO2 and temperature on growth, biomass and secondary metabolite of Hypericum perforatum L. in a western Himalayan region
Publication date: Available online 31 December 2019Source: Journal of Applied Research on Medicinal and Aromatic PlantsAuthor(s): Shikha Sharma, Swati Walia, Shalika Rathore, Pawan Kumar, Rakesh KumarAbstractRising carbon dioxide [CO2] levels and air temperature influence overall growth and production pattern of crop plants, and thus they help in understanding the functional relationship between the environment and crop performance. The present experiment was conducted to study the simultaneous effect of elevated CO2 (550 ± 50 µmol mol-1) and air temperature (2.5 ± 0.5...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - January 1, 2020 Category: Complementary Medicine Source Type: research

Inhibition of pancreatic lipase by the constituents in St. John's Wort: In vitro and in silico investigations.
Abstract Herbal medicines are frequently used for the prevention and treatment of obesity and obesity-related disorders. Our preliminary screening showed that St. John's Wort (SJW) displayed potent inhibition on pancreatic lipase (PL), a key hydrolase responsible for lipid digestion and absorption in mammals. Herein, the inhibition potentials and inhibitory mechanism of SJW extract and its major constituents on PL were fully investigated by a set of in vitro and in silico studies. The results clearly demonstrated that the naphthodianthrones, biflavones and most of flavonoids in SJW displayed strong to moderate inh...
Source: International Journal of Biological Macromolecules - December 25, 2019 Category: Biochemistry Authors: Hou XD, Guan XQ, Cao YF, Weng ZM, Hu Q, Liu HB, Jia SN, Zang SZ, Zhou Q, Yang L, Ge GB, Hou J Tags: Int J Biol Macromol Source Type: research

Genome-wide identification and characterization of R2R3-MYB family in Hypericum perforatum under diverse abiotic stresses.
This study was the first report on identification and characterization of R2R3-MYB gene family in H. perforatum. It facilitated the identification of tissue-preferential and stress-related genes and provided deep insights into the function of R2R3-MYBs in H. perforatum. PMID: 31857171 [PubMed - as supplied by publisher] (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - December 15, 2019 Category: Biochemistry Authors: Zhou W, Zhang Q, Sun Y, Yang L, Wang Z Tags: Int J Biol Macromol Source Type: research

Herbal Interaction With Chemotherapeutic Drugs —A Focus on Clinically Significant Findings
This study reviews relevant literature and identified six herbal products namely echinacea, garlic, ginseng, grapefruit juice, milk thistle, and St John's wort, which have shown interactions with chemotherapeutic agents in humans. This focus on clinically significant herb-drug interaction, should be of interest to the public including practitioners, researchers, and consumers of cancer chemotherapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 2, 2019 Category: Cancer & Oncology Source Type: research

Gastroprotective herbs for headache management in Persian medicine: a comprehensive review
Publication date: Available online 23 November 2019Source: Journal of Integrative MedicineAuthor(s): Maryam Naeimi, Narjes Gorji, Zahra Memariani, Reihaneh Moeini, Mohammad Kamalinejad, Fatemeh KolangiAbstractThe gut-brain axis is a bidirectional communication system that exists between the brain and gut. Several studies claimed that some types of headaches are associated with various gastrointestinal (GI) disorders. In Persian medicine (PM), physicians believed gastric disturbances could stimulate headache and introduced some herbs for boosting gastric function as a therapeutic remedy for headache. Here we review the curr...
Source: Journal of Integrative Medicine - November 23, 2019 Category: Complementary Medicine Source Type: research

The effect of hypericum perforatum oil on the healing process in the care of episiotomy wounds: A randomized controlled trial
This study investigated whether the use of Hypericum perforatum (HP) oil used for wound care for women who had received an episiotomy to facilitate labour could be effective in facilitating healing.MethodsThis controlled single-blind and randomized experimental study with a pretest-posttest design. was conducted in a Training and Research Hospital for Gynecology and Obstetrics in Northern Turkey. The 135 women agreeing to participate in the study were randomised into 3 groups: 45 women who used only Saline Solution (SS), 45 women who were treated with HP oil and 45 women who received routine clinical care after episiotomy,...
Source: European Journal of Integrative Medicine - November 20, 2019 Category: Complementary Medicine Source Type: research

Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L.
In this study, the antiviral activities of H. perforatum on infectious bronchitis virus (IBV) were evaluated in vitro and in vivo for the first time. The results of in vitro experiments confirmed that the antiviral component of H. perforatum was ethyl acetate extraction section (HPE), and results showed that treatment with HPE significantly reduced the relative messenger ribonucleic acid (mRNA) expression and virus titer of IBV, and reduced positive green immunofluorescence signal of IBV in chicken embryo kidney (CEK) cells. HPE treatment at doses of 480–120 mg/kg for 5 days, reduced IBV induced injury in the trachea...
Source: Frontiers in Pharmacology - October 28, 2019 Category: Drugs & Pharmacology Source Type: research

Endemic North American Plants as Potentially Suitable Agents for Wound Cleaning Under Resource Scarce Conditions
ConclusionsThese data suggest that both St. John’s wort and white oak are potential candidates for infection prophylaxis and therapy in austere wilderness scenarios, with St. John’s wort being the more potent agent. White oak may be more logistically feasible because the larger surface area of a white oak tree allows for harvesting a larger quantity of bark compared to the smaller surface area of the St. John’s wort plant. (Source: Wilderness and Environmental Medicine)
Source: Wilderness and Environmental Medicine - October 18, 2019 Category: Environmental Health Source Type: research

Hypericum SPP.: An Update On The Biological Activities And Metabolic Profiles.
Abstract Plants from the genus Hypericum, one genera of the Hypericaceae family, have attracted a lot of attention for their potential pharmaceutical applications. Most of the studies in the literature focus on H. perforatum L. (common St. John's wort), whose complex spectrum of bioactive compounds makes this species one of the top herbal remedies and supplements in the world. It is also important to compare the studies of other Hypericum species, both from the phytochemical and from the biological point of view. The aim of this review is to provide an update of most recent studies about biological investigations ...
Source: Mini Reviews in Medicinal Chemistry - September 25, 2019 Category: Chemistry Authors: Marrelli M, Statti G, Conforti F Tags: Mini Rev Med Chem Source Type: research

Herbal detox - Benzodiazepine withdrawal treatment with the help of St. John's Wort?
Authors: Moeller S, Sitter A, Darrelmann UG, Philipsen A, Müller HHO, Wang R, Olek A PMID: 31472310 [PubMed - as supplied by publisher] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - September 1, 2019 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Interactions between clopidogrel and traditional Chinese medicine
AbstractThe use of traditional Chinese medicine (TCM) has obtained more and more acceptance all over the world due to its multi-target and multi-level function characteristics. Clopidogrel is a major therapeutic option to reduce atherothrombotic events in patients with acute coronary syndrome, recent myocardial infarction, recent stroke or established peripheral arterial disease. These patients probably take TCM. Are there any interactions between clopidogrel and TCM? Whether TCM will affect the efficacy of clopidogrel or increase the adverse reactions of bleeding? Clarifying this information will help physicians make bett...
Source: Journal of Thrombosis and Thrombolysis - August 29, 2019 Category: Hematology Source Type: research

Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland – is there potential to extend veterinary options to reduce antimicrobial use?
ConclusionNo clear differences were found between the medicinal plants used by FNS and GNS. Several of the reported plants seem to be justified to widen the spectrum of veterinary therapeutic options in gastrointestinal and dermatological disorders in cattle and horses, and to reduce, at least to a certain degree, the need for antibiotic treatments. Our findings may help to strengthen the role of medicinal plants in veterinary research and practice, and to consider them as a further measure in official strategies for lowering the use of antibiotics.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 27, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial.
This study was aimed to test the effect of Hypericum perforatum on hot flashes, menopausal symptoms, and depression in postmenopausal women. DESIGN & SETTING: This randomized controlled study was conducted on 80 postmenopausal women aged 45-60 in Izeh, Iran. INTERVENTION: Two groups received 270-330 μg of H. perforatum (n = 40) or placebo (n = 40) tablets three times a day for two months. MAIN OUTCOMES: Data were collected using a socio-demographic questionnaire, the modified Kupperman index before the intervention and 2, 4, 6 and 8 weeks after intervention. The Hami...
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Eatemadnia A, Ansari S, Abedi P, Najar S Tags: Complement Ther Med Source Type: research

Effect of Camellia sinensis, Hypericum perforatum and Urtica dioica on kidney and liver injury induced by carbon tetrachloride in rats.
This study is aimed to investigate the effects of Camellia sinensis (CS), Hypericum perforatum (HP) and Urtica dioica (UD) in kidney and liver injury induced by carbon tetrachloride (CCl4) in rats. Highly toxic CCl4 which is used as a solvent in industry comprises experimental toxicity in rats and is widely used in hepatotoxicity and other tissue injury models. The purpose of this investigation is to monitor blood and various tissues by biochemical and histopathological analysis for preventive effects of CS, HP and UD on oxidative stress induced by administration of CCl4 and to enlighten the probable mechanism. Fifty eight...
Source: Cellular and Molecular Biology - July 17, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Acid Sphingomyelinase – a Regulator of TRPC6 Channel Activity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 15, 2019 Category: Neuroscience Authors: Stefanie Zeitler, Lian Ye, Aksana Andreyeva, Fabian Schumacher, Juliana Monti, Bernd N ürnberg, Gabriel Nowak, Burkhard Kleuser, Martin Reichel, Anna Fejtová, Johannes Kornhuber, Cosima Rhein, Kristina Friedland Tags: Original Article Source Type: research

Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology.
Abstract This paper presents the successful application of ultrasound-assisted packed-bed (UAE-PB) method for the extraction of hypericin from the Hypericum perfuratum L. The Soxhlet system was utilized for the determination of suitable solvent from ethanol, methanol or from the mixture of different proportions of ethanol-methanol. The mixture of 50:50 v/v ethanol-methanol was obtained to be the most suitable solvent since it led to the highest extraction amount of hypericin. The extraction amount of hypericin increased by 13.6% and 21.4% when the solvent changed from pure methanol to the mixture of 50:50 v/v etha...
Source: Ultrasonics Sonochemistry - June 20, 2019 Category: Chemistry Authors: Tahmasebi-Boldaji R, Hatamipour MS, Khanahmadi M, Sadeh P, Najafipour I Tags: Ultrason Sonochem Source Type: research