Molecules, Vol. 29, Pages 1756: Four New Polyprenylated Acylphloroglucinols from Hypericum perforatum L.
Jinming Gao
Hyperforatums A–D (1–4), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John’s wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Hyperforatum A featured an unusual chromene-1,4-dione bicyclic system, and hyperforatums B and C were two rare monocyclic PPAPs with five-membered furanone cores. Compound 1 exhibited a mo...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Xiaoying Wang Wuyang Liu Sheng Chen Yueshan Gao Junmian Tian Jinming Gao Tags: Article Source Type: research
Do nanoparticles delivered to roots affect plant secondary metabolism? A comprehensive analysis in float seedling cultures of Hypericum perforatum L
Chemosphere. 2024 Mar 28:141789. doi: 10.1016/j.chemosphere.2024.141789. Online ahead of print.ABSTRACTSince nanoparticles (NPs), either released from household wastes or applied directly to plants as agrochemicals, can accumulate in the rhizosphere, it is imperative to understand how plant secondary metabolism is affected when the roots of an intact plant are exposed to NPs. Here, the effects of Pd, Au, ZnO and Fe2O3 NPs on secondary metabolism were comprehensively investigated by analyzing 41 major secondary metabolites using ultra-performance liquid chromatography coupled with photodiode array, fluorescence detector and...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Matam Pradeep Megha Saxena Dibyendu Mondal Gregory Franklin Source Type: research
Do nanoparticles delivered to roots affect plant secondary metabolism? A comprehensive analysis in float seedling cultures of Hypericum perforatum L
Chemosphere. 2024 Mar 28:141789. doi: 10.1016/j.chemosphere.2024.141789. Online ahead of print.ABSTRACTSince nanoparticles (NPs), either released from household wastes or applied directly to plants as agrochemicals, can accumulate in the rhizosphere, it is imperative to understand how plant secondary metabolism is affected when the roots of an intact plant are exposed to NPs. Here, the effects of Pd, Au, ZnO and Fe2O3 NPs on secondary metabolism were comprehensively investigated by analyzing 41 major secondary metabolites using ultra-performance liquid chromatography coupled with photodiode array, fluorescence detector and...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Matam Pradeep Megha Saxena Dibyendu Mondal Gregory Franklin Source Type: research
Do nanoparticles delivered to roots affect plant secondary metabolism? A comprehensive analysis in float seedling cultures of Hypericum perforatum L
Chemosphere. 2024 Mar 28:141789. doi: 10.1016/j.chemosphere.2024.141789. Online ahead of print.ABSTRACTSince nanoparticles (NPs), either released from household wastes or applied directly to plants as agrochemicals, can accumulate in the rhizosphere, it is imperative to understand how plant secondary metabolism is affected when the roots of an intact plant are exposed to NPs. Here, the effects of Pd, Au, ZnO and Fe2O3 NPs on secondary metabolism were comprehensively investigated by analyzing 41 major secondary metabolites using ultra-performance liquid chromatography coupled with photodiode array, fluorescence detector and...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Matam Pradeep Megha Saxena Dibyendu Mondal Gregory Franklin Source Type: research
Do nanoparticles delivered to roots affect plant secondary metabolism? A comprehensive analysis in float seedling cultures of Hypericum perforatum L
Chemosphere. 2024 Mar 28:141789. doi: 10.1016/j.chemosphere.2024.141789. Online ahead of print.ABSTRACTSince nanoparticles (NPs), either released from household wastes or applied directly to plants as agrochemicals, can accumulate in the rhizosphere, it is imperative to understand how plant secondary metabolism is affected when the roots of an intact plant are exposed to NPs. Here, the effects of Pd, Au, ZnO and Fe2O3 NPs on secondary metabolism were comprehensively investigated by analyzing 41 major secondary metabolites using ultra-performance liquid chromatography coupled with photodiode array, fluorescence detector and...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Matam Pradeep Megha Saxena Dibyendu Mondal Gregory Franklin Source Type: research
Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR < sub > 2 < /sub > /SRC pathway in vascular cognitive impairment mice
CONCLUSION: Hyperforin effectively modulated microglial M1 polarization and neuroinflammation by inhibiting the VEGFR2 /SRC signaling pathways, thereby ameliorating WMLs and cognitive impairment in VCI mice.PMID:38468126 | DOI:10.1111/cns.14666 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xin Gao Jingjing Chen Ge Yin Yanqun Liu Zhengsheng Gu Rui Sun Xu Sun Xuehao Jiao Ling Wang Nuo Wang Yanbo Zhang Yuting Kan Xiaoying Bi Bingying Du Source Type: research
Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR < sub > 2 < /sub > /SRC pathway in vascular cognitive impairment mice
CONCLUSION: Hyperforin effectively modulated microglial M1 polarization and neuroinflammation by inhibiting the VEGFR2 /SRC signaling pathways, thereby ameliorating WMLs and cognitive impairment in VCI mice.PMID:38468126 | DOI:10.1111/cns.14666 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xin Gao Jingjing Chen Ge Yin Yanqun Liu Zhengsheng Gu Rui Sun Xu Sun Xuehao Jiao Ling Wang Nuo Wang Yanbo Zhang Yuting Kan Xiaoying Bi Bingying Du Source Type: research
Safety Issues of Herb-Warfarin Interactions
Curr Drug Metab. 2024 Mar 8. doi: 10.2174/0113892002290846240228061506. Online ahead of print.ABSTRACTWarfarin is a popular anticoagulant with high global demand. However, studies have underlined serious safety issues when warfarin is consumed concomitantly with herbs or its formulations. This review aimed to highlight the mechanisms behind herb-warfarin interactions while laying special emphasis on its PKPD interactions and evidence on Herb-Warfarin Interaction (HWI) with regards to three different scenarios, such as when warfarin is consumed with herbs taken as foods or prescribed as medicine, or when used in special sit...
Source: Current Drug Metabolism - March 11, 2024 Category: Drugs & Pharmacology Authors: Subhajit Hazra Preet Amol Singh Neha Bajwa Source Type: research
Safety Issues of Herb-Warfarin Interactions
Curr Drug Metab. 2024 Mar 8. doi: 10.2174/0113892002290846240228061506. Online ahead of print.ABSTRACTWarfarin is a popular anticoagulant with high global demand. However, studies have underlined serious safety issues when warfarin is consumed concomitantly with herbs or its formulations. This review aimed to highlight the mechanisms behind herb-warfarin interactions while laying special emphasis on its PKPD interactions and evidence on Herb-Warfarin Interaction (HWI) with regards to three different scenarios, such as when warfarin is consumed with herbs taken as foods or prescribed as medicine, or when used in special sit...
Source: Current Drug Metabolism - March 11, 2024 Category: Drugs & Pharmacology Authors: Subhajit Hazra Preet Amol Singh Neha Bajwa Source Type: research
Potential of using medicinal plant extracts as photosensitizers for antimicrobial photodynamic therapy
In this study, we used commercially available preparations (Calendulae officinalis floridis extract,Chamomillae recutitae floridis extract,Achillea millefolii herbae extract;Hypericum perforatum extract;Eucalyptus viminalis folia extract) as photosensitizers for inactivation of gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria. Spectral-luminescent analysis has shown that the major chromophores are of chlorophyll (mainly chlorophylla andb) and hypericin nature. The extracts are efficient generators of singlet oxygen with quantum yield (γΔ) from 0.40 to 0.64 (reference compound, met...
Source: Photochemistry and Photobiology - March 8, 2024 Category: Science Authors: Aliaksandr V. Mikulich,
Vitaly Yu. Plavskii,
Antonina I. Tretyakova,
Raman K. Nahorny,
Andrey N. Sobchuk,
Natalia V. Dudchik,
Olga A. Emeliyanova,
Anastasia I. Zhabrouskaya,
Ludmila G. Plavskaya,
Tatsiana S. Ananich,
Olga N. Dudinova,
Ihar A. L Tags: RESEARCH ARTICLE Source Type: research
The Effect of St. John's Wort Oil (Hypericum Perforatum L.) in Knee Osteoarthritis: A Randomized Controlled and Qualitative Study
Reducing pain and improving physical function are critical in the treatment of osteoarthritis. Although individuals use St. John's Wort oil to relieve pain due to osteoarthritis, no scientific research has been found investigating its effectiveness. (Source: Pain Management Nursing)
Source: Pain Management Nursing - January 18, 2024 Category: Nursing Authors: Deniz Zeynep S önmez, Sultan Taşcı Tags: Original Article Source Type: research
Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells
In conclusion, hypericin, but not hyperforin or citalopram, is a mitochondrial toxicant at low micromolar concentrations. This mechanism may contribute to the hepatotoxicity occasionally observed in susceptible patients treated with St. John's Wort preparations.PMID:38219807 | DOI:10.1016/j.toxlet.2024.01.008 (Source: Toxicology Letters)
Source: Toxicology Letters - January 14, 2024 Category: Toxicology Authors: Vanessa Fabienne Abegg Miljenko Valentin Panajatovic Riccardo Vincenzo Mancuso Julien Arthur Allard Urs Duthaler Alex Odermatt Stephan Kr ähenbühl Jamal Bouitbir Source Type: research
Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review
CONCLUSION: Overall level of evidence for the included studies were low, though interactions between cyclosporine, tacrolimus, Hypericum perforatum and Schisandra sphenanthera were the most and well-documented. Healthcare professionals should actively enquire about the concurrent use of CHM in patients, especially when drugs with a narrow therapeutic index are consumed.PMID:38218549 | DOI:10.1016/j.ctim.2024.103017 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - January 13, 2024 Category: Complementary Medicine Authors: Ting Hui Woon Melissa Jia Hui Tan Yu Heng Kwan Warren Fong Source Type: research
Effect of Tacrolimus Formulation (Prolonged ‐Release vs Immediate‐Release) on Its Susceptibility to Drug‐Drug Interactions with St. John's Wort
AbstractTacrolimus is metabolized by cytochrome P450 3A (CYP3A) and is susceptible to interactions with the CYP3A and P-glycoprotein inducer St. John's Wort (SJW). CYP3A isozymes are predominantly expressed in the small intestine and liver. Prolonged-release tacrolimus (PR-Tac) is largely absorbed in distal intestinal segments and is less susceptible to CYP3A inhibition. The effect of induction by SJW is unknown. In this randomized, crossover trial, 18 healthy volunteers received single oral tacrolimus doses (immediate-release [IR]-Tac or PR-Tac, 5 mg each) alone and during induction by SJW. Concentrations were quantifie...
Source: Clinical Pharmacology in Drug Development - January 5, 2024 Category: Drugs & Pharmacology Authors: Katja S. G ümüs,
Anna Teegelbekkers,
Max Sauter,
Andreas D. Meid,
Jürgen Burhenne,
Johanna Weiss,
Antje Blank,
Walter E. Haefeli,
David Czock Tags: Original Article Source Type: research
Antibacterial activity of < em > Hypericum perforatum < /em > L. (St. John's wort) extracts against Gram-positive bacteria and characterisation of its secondary metabolites
This study aimed to determine the secondary metabolite profiles and antibacterial activity of H. perforatum L extracts against Gram-positive clinical isolates. The plant materials (Sample A and Sample B) were macerated with n-hexane, ethyl acetate and methanol (MeOH). The antibacterial activitiy of plant extracts and routinely used antibiotics were tested against Gram-positive bacteria. The secondary metabolite profiles of Sample A were determined by LC-Q-TOF-MS. The MIC values for n-hexane and ethyl acetate extracts of Sample A were lower than the susceptibility breakpoints of most broad-spectrum antibiotics (e.g. vancomy...
Source: Natural Product Research - December 14, 2023 Category: Biochemistry Authors: Ozgul Kisa Lutfiye Oksuz Huseyin Servi Ayhan Ibrahim Aysal Source Type: research
