Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats
In conclusion, HP.SNESNS (100 mg/kg) exerted antidepressant and cardioprotective activities in the post-MI depression rat model.PMID:36028598 | DOI:10.1208/s12249-022-02387-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - August 26, 2022 Category: Drugs & Pharmacology Authors: Heba M A Khalil Dina B Mahmoud Riham A El-Shiekh Alaa F Bakr Amira A Boseila Sally Mehanna Reham A Naggar Hesham A Eliwa Source Type: research
Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2
In this study, hydroethanolic extracts of 30 top-selling botanicals (herbs) commonly used as ingredients of herbal dietary supplements in the US were screened for their potential to activate the human pregnane X receptor (hPXR) and human aryl hydrocarbon receptor (hAhR) and to increase the activities of hPXR- and hAhR-regulated drug metabolizing cytochrome P450 enzymes (i.e., CYP3A4 and CYP1A2, respectively). Of the 30 botanicals tested, 21 induced PXR and 29 induced AhR transcriptional activities. Out of the 21 botanicals that induced hPXR transcriptional activity, 14 yielded >50% induction in CYP3A4 activity at concen...
Source: Journal of Dietary Supplements - August 26, 2022 Category: Nutrition Authors: Mona H Haron Olivia Dale Katherine Martin Bharathi Avula Amar G Chittiboyina Ikhlas A Khan Bill J Gurley Shabana I Khan Source Type: research
Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication
CONCLUSION: Hypericin inhibits the bioactivity of AN and suppresses HSV-1 replication. The data revealed a novel mechanism of the antiherpetic effect of hypericin.PMID:35811028 | DOI:10.1016/j.jep.2022.115524 (Source: Herpes)
Source: Herpes - July 10, 2022 Category: Infectious Diseases Authors: Kang Cao Yan Zhang Qian Yao Yanjuan Peng Qu Pan Qiuxia Jiao Ke Ren Fenghui Sun Qian Zhang Ran Guo Jiali Zhang Tian Chen Source Type: research
Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication
CONCLUSION: Hypericin inhibits the bioactivity of AN and suppresses HSV-1 replication. The data revealed a novel mechanism of the antiherpetic effect of hypericin.PMID:35811028 | DOI:10.1016/j.jep.2022.115524 (Source: Herpes)
Source: Herpes - July 10, 2022 Category: Infectious Diseases Authors: Kang Cao Yan Zhang Qian Yao Yanjuan Peng Qu Pan Qiuxia Jiao Ke Ren Fenghui Sun Qian Zhang Ran Guo Jiali Zhang Tian Chen Source Type: research
Medicinal Plants Used Traditionally for Skin Related Problems in the South Balkan and East Mediterranean Region —A Review
A review research was conducted to provide an overview of the ethnobotanical knowledge of medicinal plants and traditional medical practices for the treatment of skin disorders in Albania, Cyprus, Greece, and Turkey. The geographical and ecological characteristics of the Balkan Peninsula and Mediterranean Sea, along with the historical connection among those countries, gave rise to the development of a distinct flora and to the uses of common medicinal plants against various skin ailments, respectively. The review focuses on the detailed study of 128 ethnobotanical surveys conducted in these areas and the species used for ...
Source: Frontiers in Pharmacology - July 5, 2022 Category: Drugs & Pharmacology Source Type: research
Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies
Globally, the search for safe and potent natural-based treatment for depression is receiving renewed interest given the numerous side-effects associated with many existing drugs. In South Africa, the use of plants to manage depression and related symptoms is fairly documented among different ethnic groups. In the current study, we reviewed existing ethnobotanical, ethnopharmacological and phytochemical studies on South African medicinal plants used to manage depression. Electronic databases were accessed for scientific literature that meets the inclusion criteria. Plants with ethnobotanical evidence were subjected to a fur...
Source: Frontiers in Pharmacology - June 29, 2022 Category: Drugs & Pharmacology Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
