Determination of Potential Drug Candidate Molecules of the < em > Hypericum perforatum < /em > for COVID-19 Treatment
Curr Pharmacol Rep. 2021 Mar 2:1-7. doi: 10.1007/s40495-021-00254-9. Online ahead of print.ABSTRACTThe novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against this disease both in Turkey and around the world include chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, and remdesivir. In the study, we investigated the drug potential of molecules that the components of an important medicinal plant Hypericum perforatum by using molecular docking and drug...
Source: Pharmacological Reports - March 8, 2021 Category: Drugs & Pharmacology Authors: Serap Yal çın Seda Yal çınkaya Fahriye Ercan Source Type: research
High purity separation of hypericin from Hypericum perforatum L. extract with macroporous resin column coupling preparative liquid chromatography
Publication date: Available online 21 February 2021Source: Process BiochemistryAuthor(s): Jie Zhang, Chunrong Feng, Pu Ge, Qingqing Wang, Yanling Liu, Hui Xu, Xing Zhou (Source: Process Biochemistry)
Source: Process Biochemistry - February 22, 2021 Category: Biochemistry Source Type: research
Plant-based Medicines (Phytoceuticals) in the Treatment of Psychiatric Disorders: A Meta-review of Meta-analyses of Randomized Controlled Trials: Les m édicaments à base de plantes (phytoceutiques) dans le traitement des troubles psychiatriques: une méta-revue des méta-analyses d'essais randomisés contrôlés.
CONCLUSIONS: More rigorous international studies are required to validate the efficacy of these phytoceuticals before treatment recommendations can be made. In conclusion, the breadth of data tentatively supports several phytoceuticals which may be effective for mental disorders alongside pharmaceutical, psychological therapies, and standard lifestyle recommendations.
PMID: 33596697 [PubMed - as supplied by publisher] (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - February 18, 2021 Category: Psychiatry Authors: Sarris J, Marx W, Ashton MM, Ng CH, Galvao-Coelho N, Ayati Z, Zhang ZJ, Kasper S, Ravindran A, Harvey BH, Lopresti A, Mischoulon D, Amsterdam J, Yatham LN, Berk M Tags: Can J Psychiatry Source Type: research
Fostemsavir: The first oral attachment inhibitor for treatment of HIV-1 infection.
CONCLUSION: Fostemsavir may be an effective option for heavily treatment-experienced adults with multidrug-resistant HIV-1 infection. Fostemsavir is a particularly attractive treatment option for patients who are no longer able to achieve viral suppression with use of currently available antiretroviral therapies and who are able to adhere to a twice-daily oral regimen.
PMID: 33547469 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 6, 2021 Category: Drugs & Pharmacology Authors: Chahine EB Tags: Am J Health Syst Pharm Source Type: research
Prediction of hypericin content in Hypericum perforatum L. in different ecological habitat using artificial neural networks
Hypericum is an important genus in the family Hypericaceae, which includes 484 species. This genus has been grown in temperate regions and used for treating wounds, eczema and burns. The aim of this study was to ... (Source: Plant Methods)
Source: Plant Methods - January 26, 2021 Category: Biology Authors: Maryam Saffariha, Ali Jahani, Reza Jahani and Sajid Latif Tags: Research Source Type: research
