Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of < em > Hypericum perforatum < /em > L. with antiangiogenic activities

Nat Prod Res. 2023 Dec 5:1-7. doi: 10.1080/14786419.2023.2278176. Online ahead of print.ABSTRACTThree new acylphloroglucinols were isolated from the branches and leaves of Hypericum perforatum L., named as hyperipersions A-C (1-3), together with three known compounds which were identified as elegaphenone (4), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (5) and 2,3-methylenedioxyxanthone (6), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC50 value of compound 3 was 2.39 ± 0.21 μM against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.PMID:38050718 | DOI:10.1080/14786419.2023.2278176
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research