IJERPH, Vol. 20, Pages 5298: Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity

IJERPH, Vol. 20, Pages 5298: Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20075298 Authors: Isabel A. Sánchez Jaime A. Cuchimba María C. Pineda Yenny P. Argüello Jana Kočí Richard B. Kreider Jorge L. Petro Diego A. Bonilla Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46.4%, we found that: (i) Hypericum perforatum (St. John’s Wort) is the most studied and supported adaptogen (17/41 [41.46%], three systematic reviews with meta-analysis) followed by Crocus sativus L. or saffron (6/41 [14.63%], three systematic reviews with meta-analysis and two systematic reviews); (ii) it is possible that the significantly better performance of adaptogens over placebo is due to the reduction of allostatic load via the action of secondar...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Systematic Review Source Type: research