A case of insulinoma misidentified as schizophrenia due to its manifestation in neuropsychiatric symptoms
AbstractInsulinomas can present with neuroglycopenic symptoms suggesting neuropsychiatric disorders, delaying diagnosis and treatment. We recently treated a 65-year-old woman with insulinoma who was misdiagnosed at her nearby psychiatric clinic as having schizophrenia because of personality changes and memory impairment; she was treated with brexpiprazole, which was discontinued due to persistence of the symptoms. Despite her relatively low casual plasma glucose (70 mg/dL), the physician at the psychiatric clinic did not investigate the possibility of hypoglycemia, partly because her HbA1c level (5.2%) was within normal ...
Source: Diabetology International - April 21, 2024 Category: Endocrinology Source Type: research
Clinical and neurodevelopmental predictors of psychotic disorders in children and adolescents at clinical high risk for psychosis: the CAPRIS study
AbstractBackgroundThe neurodevelopmental hypothesis of schizophrenia represents the disorder as an expression of an alteration during the brain development process early in life. Neurodevelopmental variables could become a trait marker, and the study of these variables in children and adolescents at clinical high risk for psychosis (CHR) could identify a specific cluster of patients who later developed psychosis. The aim of this study is to describe clinical and neurodevelopment predictors of transition to psychosis in child and adolescent participants at CHR. Naturalistic longitudinal two-center study of 101 CHR and 110...
Source: European Child and Adolescent Psychiatry - April 20, 2024 Category: Psychiatry Source Type: research
One in Four People With Schizophrenia or Bipolar Have Multiple Physical Health Problems
Astudy inLancet Psychiatry reports that adults with schizophrenia or bipolar disorder are more than twice as likely as those without these disorders to have multiple physical health problems like heart disease or diabetes. Further, the presence of multiple physical problems was more common in adults with schizophrenia or bipolar disorder than the presence of multiple psychiatric disorders.“While health services and treatment guidelines often operate on the assumption that individuals have a single principal diagnosis, these results attest to the clinical complexity many people with severe mental illness face in relation ...
Source: Psychiatr News - April 19, 2024 Category: Psychiatry Tags: bipolar disorder chronic disease comorbidities Lancet Psychiatry physical health premature mortality schizophrenia Source Type: research
Changes in psychopharmacotherapy for patients with schizophrenia in a psychiatric institution in Japan: A 12-year prescription survey pre- and post-introduction of clozapine
Asian J Psychiatr. 2024 Apr 9;96:104047. doi: 10.1016/j.ajp.2024.104047. Online ahead of print.ABSTRACTPsychopharmacotherapy for patients with schizophrenia in Japan has a long history of polypharmacy, which is rare worldwide but remains a critical problem. One reason for this is that clozapine was not available in Japan until 2009. We aimed to investigate the changes in psychopharmacotherapy in patients with schizophrenia over 12 years pre- and post-introduction of clozapine to clarify how psychopharmacotherapy for patients with schizophrenia has changed with the introduction of clozapine. We retrospectively collected dat...
Source: Asian Journal of Psychiatry - April 19, 2024 Category: Psychiatry Authors: Kohei Kitagawa Shusuke Uekusa Yuki Hanai Itsuki Kimura Masaru Tsukahara Azusa Kagawa Kenji Sasaoka Yui Sakishiro Ayaka Miyake Yuki Watanabe Daiki Baba Masafumi Kodama Yoshiki Kishi Norihito Yamada Takashi Yoshio Kazuhiro Matsuo Source Type: research
Mendelian randomization: causal inference leveraging genetic data
Psychol Med. 2024 Apr 19:1-14. doi: 10.1017/S0033291724000321. Online ahead of print.ABSTRACTMendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for the appropriate application and interpretation of MR. This review aims to provide a non-technical overview of MR and demonstrat...
Source: Psychological Medicine - April 19, 2024 Category: Psychiatry Authors: Lane G Chen Justin D Tubbs Zipeng Liu Thuan-Quoc Thach Pak C Sham Source Type: research
M < sub > 1 < /sub > /M < sub > 4 < /sub > receptors as potential therapeutic treatments for schizophrenia: A comprehensive study
Bioorg Med Chem. 2024 Apr 16;105:117728. doi: 10.1016/j.bmc.2024.117728. Online ahead of print.ABSTRACTMuscarinic acetylcholine receptors (mAChRs) play a significant role in the pathophysiology of schizophrenia. Although activating mAChRs holds potential in addressing the full range of schizophrenia symptoms, clinical application of many non-selective mAChR agonists in cognitive deficits, positive and negative symptoms is hindered by peripheral side effects (gastrointestinal disturbances and cardiovascular effects) and dosage restrictions. Ligands binding to the allosteric sites of mAChRs, particularly the M1 and M4 subtyp...
Source: Bioorganic and Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Lingsheng Fu Yi Luo Longyan Niu Ying Lin Xingru Chen Junhao Zhang Weifang Tang Yadong Chen Yu Jiao Source Type: research
Effect of propranolol on pharmacokinetics of clozapine in schizophrenic patients: a meta-analysis
ConclusionThe combination with propranolol could significantly increase systemic exposure and extendedT1/2 of clozapine, and thus need to be considered in prescribing decisions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Source Type: research
Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia
Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relations... (Source: BMC Psychiatry)
Source: BMC Psychiatry - April 19, 2024 Category: Psychiatry Authors: Huang-Hui Liu, Yao Gao, Dan Xu, Xin-Zhe Du, Si-Meng Wei, Jian-Zhen Hu, Yong Xu and Liu Sha Tags: Research Source Type: research
Most People Experiencing Homelessness Have Mental Health Disorders, Study Finds
Sixty-seven percent of people experiencing homelessness worldwide have a mental health disorder, according to areport published yesterday inJAMA Psychiatry. Additionally, the prevalence of mental health disorders among this population appears to be on the rise.“The relationship between mental health disorders and homelessness is complex and bidirectional,” wrote Rebecca Barry, Ph.D., of the University of Calgary and colleagues. “[M]ental health disorders may lead to situations that result in homelessness, or homelessness may be a stressor contributi ng to the development or worsening of mental health disorder symptom...
Source: Psychiatr News - April 18, 2024 Category: Psychiatry Tags: antisocial personality disorder homeless JAMA Psychiatry mental health disorders meta-analysis North America Rebecca Barry schizophrenia substance use disorders systematic review University of Calgary Source Type: research
Demographics and clinical characteristics of patients of prescribing psychologists, psychiatrists, and primary care physicians
Am Psychol. 2024 Apr 18. doi: 10.1037/amp0001352. Online ahead of print.ABSTRACTTo describe the characteristics of patients receiving psychotropic medication from prescribing psychologists, psychiatrists, and primary care physicians. This descriptive study was conducted using private insurance claims of patients from New Mexico and Louisiana receiving psychotropic medications (anticonvulsants, antidepressants, antipsychotics, hypotensive agents, anxiolytics/sedatives/hypnotics, and stimulants) from 2004 to 2021 (N = 307,478). Patient characteristics were captured during the 6 months prior to their first psychotropic medica...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Phillip M Hughes Joshua D Niznik Robert E McGrath Casey R Tak Robert B Christian Betsy L Sleath Kathleen C Thomas Source Type: research
The association between schizophrenia and increased COVID-19 mortality in a cohort of over 2 million people in Brazil
CONCLUSIONS: Patients diagnosed with schizophrenia have a greater likelihood of COVID-19- related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on COVID-19 mortality.PMID:38635950 | DOI:10.47626/1516-4446-2024-3540 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 18, 2024 Category: Psychiatry Authors: Fabr ício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L Oliveira Enrico A Colosimo Herc ílio Martelli Eduardo Ara újo Oliveira Source Type: research
The association between schizophrenia and increased COVID-19 mortality in a cohort of over 2 million people in Brazil
CONCLUSIONS: Patients diagnosed with schizophrenia have a greater likelihood of COVID-19- related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on COVID-19 mortality.PMID:38635950 | DOI:10.47626/1516-4446-2024-3540 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 18, 2024 Category: Psychiatry Authors: Fabr ício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L Oliveira Enrico A Colosimo Herc ílio Martelli Eduardo Ara újo Oliveira Source Type: research
Demographics and clinical characteristics of patients of prescribing psychologists, psychiatrists, and primary care physicians
Am Psychol. 2024 Apr 18. doi: 10.1037/amp0001352. Online ahead of print.ABSTRACTTo describe the characteristics of patients receiving psychotropic medication from prescribing psychologists, psychiatrists, and primary care physicians. This descriptive study was conducted using private insurance claims of patients from New Mexico and Louisiana receiving psychotropic medications (anticonvulsants, antidepressants, antipsychotics, hypotensive agents, anxiolytics/sedatives/hypnotics, and stimulants) from 2004 to 2021 (N = 307,478). Patient characteristics were captured during the 6 months prior to their first psychotropic medica...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Phillip M Hughes Joshua D Niznik Robert E McGrath Casey R Tak Robert B Christian Betsy L Sleath Kathleen C Thomas Source Type: research
The association between schizophrenia and increased COVID-19 mortality in a cohort of over 2 million people in Brazil
CONCLUSIONS: Patients diagnosed with schizophrenia have a greater likelihood of COVID-19- related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on COVID-19 mortality.PMID:38635950 | DOI:10.47626/1516-4446-2024-3540 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 18, 2024 Category: Psychiatry Authors: Fabr ício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L Oliveira Enrico A Colosimo Herc ílio Martelli Eduardo Ara újo Oliveira Source Type: research
Demographics and clinical characteristics of patients of prescribing psychologists, psychiatrists, and primary care physicians
Am Psychol. 2024 Apr 18. doi: 10.1037/amp0001352. Online ahead of print.ABSTRACTTo describe the characteristics of patients receiving psychotropic medication from prescribing psychologists, psychiatrists, and primary care physicians. This descriptive study was conducted using private insurance claims of patients from New Mexico and Louisiana receiving psychotropic medications (anticonvulsants, antidepressants, antipsychotics, hypotensive agents, anxiolytics/sedatives/hypnotics, and stimulants) from 2004 to 2021 (N = 307,478). Patient characteristics were captured during the 6 months prior to their first psychotropic medica...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Phillip M Hughes Joshua D Niznik Robert E McGrath Casey R Tak Robert B Christian Betsy L Sleath Kathleen C Thomas Source Type: research
