402. Using Cognitive Phenotypes to Parse Biological Pathways in Schizophrenia
We previously investigated genetic mechanisms underlying the paradoxical relationship between cognitive ability, educational attainment, and schizophrenia (PMID: 31374203). Leveraging genetic pleiotropy, we identified two subsets of SNPs: 1) those with “concordant” alleles, following the expected association pattern (lower cognition/education and greater illness risk); and 2) those with “discordant” alleles, exhibiting a counterintuitive pattern (higher educational attainment and/or cognitive ability but greater schizophrenia susceptibilit y). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jibin John, Upasana Bhattacharyya, Todd Lencz, Max Lam Source Type: research
397. Assessing the Potential Role of Platelets in Metabolic Syndrome-Related Cognitive Impairment in Veterans With Schizophrenia
Schizophrenia is associated with progressive cognitive decline. Metabolic syndrome (MetS) —characterized by truncal obesity, insulin resistance, dyslipidemia and hypertension—is highly prevalent in individuals with schizophrenia and has been associated with cognitive impairment, but the underlying mechanism is not known. We sought to determine whether Veterans with schizophrenia como rbid with MetS (relative to those without MetS) have: 1) worse cognition; 2) higher level of platelet activation, and 3) whether platelet activation is negatively correlated with cognitive function. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Olaoluwa Okusaga, Vinod Vijayan, Rolando Rumbaut Source Type: research
395. Schizophrenia-Associated Phosphorylation of MAP2 Alters its Interactome
Microtubule-associated protein 2 (MAP2) is hyperphosphorylated in schizophrenia, with serine at position 1782 being the most elevated phosphorylation site. Mutation of serine 1782 of MAP2 to glutamine (S1782E) to mimic the phosphorylated state in mice resulted in reduced dendritic length and spine density, neuronal pathologies found in schizophrenia. MAP2 functions through interactions with other proteins, affected by phosphorylation. Here, we used co-immunoprecipitation (Co-IP) and mass spectrometry (MS) to investigate how S1782E influences MAP2 interactome. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jiali Lyu, Susan Erickson, Rebecca DeGiosio, Matthew MacDonald, Robert Sweet, Melanie Grubisha Source Type: research
391. Schizophrenia Genetic Resilience Score Moderates Environmental Risk on Working Memory Connectivity
Schizophrenia is characterized by abnormalities in functional integration of working memory (WM) brain networks. Exposure to environmental risks during critical periods of brain development can disrupt the typical trajectory of brain maturation and increase risk of schizophrenia. Investigating how genetic resilience, defined as heritable measure of variation that increases resistance to disease by reducing the impact of risk loci, influences this link is critical to understanding the disorder ’s causal mechanisms. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Didenur Sahin, Hao Yang Tan, Shizhong Han, Daniel R. Weinberger, Timothea Toulopoulou Source Type: research
390. Evaluation of the Glymphatic System in Schizophrenia Using 1H-MRS and MRI
The glymphatic system (GS), a brain waste clearance pathway, is disrupted in various neurodegenerative and vascular diseases. As schizophrenia shares clinical characteristics with these conditions, we hypothesized GS disruptions in patients with schizophrenia, reflected in increased brain macromolecule (MM) levels and decreased diffusion-tensor-image analysis along the perivascular space (DTI-ALPS) index. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ali Abdolizadeh, Edgardo Torres-Carmona, Yasaman Kambari, Aron Amaev, Jianmeng Song, Fumihiko Ueno, Teruki Koizumi, Shinichiro Nakajima, Philip Gerretsen, Ariel Graff-Guerrero Source Type: research
389. The Anxiolytic Effect of Atypical Antipsychotics in Patients With Schizophrenia: A Systematic Review and Meta-Analysis
Despite the high prevalence of anxiety in schizophrenia, no established guideline exists for the management of these symptoms. We aimed to synthesize evidence on anxiolytic effects of atypical antipsychotics (AAPs) in patients with schizophrenia. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ali Abdolizadeh, Maryam Hosseini Kupaei, Yasaman Kambari, Aron Amaev, Vittal Korann, Edgardo Torres-Carmona, Jianmeng Song, Fumihiko Ueno, Teruki Koizumi, Shinichiro Nakajima, Sri Mahavir Agarwal, Philip Gerretsen, Ariel Graff-Guerrero Source Type: research
388. Amygdala Subnuclei Volumes in Early Psychosis
This study examines amygdala subnuclei volume abnormalities in early psychosis. Based on prior findings, we hypothesized the most pronounced volume deficiencies in lateral and basal nuclei. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Niels Janssen, Karin Yoshida, Yi-Kuan Li, Sean Choi, Matthew Rosborough, Uriel Elvira, Theo van Erp Source Type: research
387. Hippocampal Subregion Volumes in Early Psychosis
This study examines hippocampal subregion abnormalities in early psychosis. Based on prior findings, we hypothesized the most pronounced deficiencies in the anterior hippocampal Cornu Ammonis (CA) 1 region. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Theo van Erp, Charbel Hatem, Kousha Keramati, Kathleen Carlos, Matthew Rosborough, Julia Alem án, Niels Janssen Source Type: research
386. Clinical Characteristics of Patients With a Diagnosis of Schizophrenia With Suicide Risk
Schizophrenia is a highly debilitating disorder that affects more than 24 million people worldwide. In Mexico, the Ministry of Health estimates that it affects more than 1 million people. Suicide is one of the main causes of death among people diagnosed with schizophrenia, its risk is 12 times higher than in the general population. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Olivia Olive Arias, Maria Serna Rodriguez, Alfonso Ontiveros, Luis Alberto De La Garza Garcia, Guillermo Sanchez Torres, Antonio Ali Perez Maya Source Type: research
383. Symptom Severity for Psychosis Biotype 3 Shows Unique Associations With Environmental Exposures as Measured By the Exposome Score for Schizophrenia
The identification of environmental risk factors is as an important step in investigating potential causal pathways for disease states. A recently-developed, “exposome” (ES-SCZ) model of environmentally-associated psychosis-spectrum risk, accounting for correlations between risk factors themselves, has shown promise for capturing dose-dependent risk. The Bipolar and Schizophrenia Network for Intermediate Phenotypes (BSNIP) consortium has identified d istinct psychosis biotypes clustered according to differences in cognitive, eye tracking and physiological biomarkers, which may capture biologically-defined differences i...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bryan Kromenacker, Walid Yassin, Brett A. Clementz, Matcheri Keshavan, Elena I. Ivleva, Elliot Gershon, Jennifer McDowell, Sarah Keedy, Godfrey Pearlson, S. Kristian Hill, Carol A. Tamminga Source Type: research
382. Cognition-Mediated Genetic Influences on Subthreshold Psychotic Symptoms in Adolescence
Across domains of cognitive deficits in schizophrenia (SCZ), attention is among the most significantly impaired. Deficits are present long before onset of overt illness and are also observed in unaffected first-degree relatives. Collectively, findings suggest that attention impairments and accompanying alterations in neurodevelopment may reflect genetic liability to SCZ. While hundreds of genome-wide variants associated with SCZ diagnosis have been identified, less is known about the genetic etiology of psychotic symptoms across development. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sarah Chang, Dylan Hughes, Sullivan Salone, Jinhan Zhu, Mahnoor Hyat, Jennifer Forsyth, Carrie Bearden Source Type: research
381. Schizophrenia Latent Class Subtype Identification and Characterization
We previously applied random effects latent class analysis to clinical samples to identify MDD subtypes and have extended the method to schizophrenia. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Qingqin Li, Xinghong Tang, Xueying Lyu, Lina Yang, Wim Van Der Elst, Rouhollah Abdollahi, Antonio Parrado, Francisco Talamas, Gayle Wittenberg, Wayne Drevets Source Type: research
380. A Hypomorphic TBK1 N455S Variant in a Woman With Post-Infectious Refractory Psychosis and Catatonia
TANK-binding kinase 1 (TBK1) missense mutations predispose to neurologic disease including frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS). FTD-ALS TBK1 variants have also been observed in patients with a primary schizophrenia diagnosis. TBK1 upregulates the transcription of type I interferon genes in response to bacteria including B. burgdorferi, which causes Lyme disease. Among the many functional consequences of TBK1 missense variants, a reduction in protein expression by more than 50% is considered pathogenic. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jailyn M. Izu, GenaLynne C. Mooneyham, Thomas T. Ngo, Samuel J. Pleasure, Michael R. Wilson, Avindra Nath, Christopher M. Bartley Source Type: research
379. Multivariate Transdiagnostic Neural Biomarkers of Schizophrenia and Autism Spectrum Disorders During the Empathic Accuracy Task
In this study, we aimed to identify group-specific and shared brain functional network configurations present during a social processing functional magnetic resonance imaging (fMRI) task. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ju-Chi Yu, Colin Hawco, Lindsay D. Oliver, Maria T. Secara, Iska Moxon-Emre, Fariah A. Sandhu, Zara Z. Khan, Peter Szatmari, Meng-Chuan Lai, Miklos Argyelan, James M. Gold, Sunny X. Tang, George Foussias, Robert W. Buchanan, Anil K. Malhotra, Aristotle N. Source Type: research
331. Disruption of Consciousness Depends on Insight in OCD and on Positive Symptoms in Schizophrenia
Disruption of conscious access contributes to the advent of psychotic symptoms in schizophrenia but could also explain lack of insight in other psychiatric disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Selim Tumkaya, Beng ü Yücens, Muhammet Gündüz, Maxime Maheu, Lucie Berkovitch Source Type: research
