395. Schizophrenia-Associated Phosphorylation of MAP2 Alters its Interactome

Microtubule-associated protein 2 (MAP2) is hyperphosphorylated in schizophrenia, with serine at position 1782 being the most elevated phosphorylation site. Mutation of serine 1782 of MAP2 to glutamine (S1782E) to mimic the phosphorylated state in mice resulted in reduced dendritic length and spine density, neuronal pathologies found in schizophrenia. MAP2 functions through interactions with other proteins, affected by phosphorylation. Here, we used co-immunoprecipitation (Co-IP) and mass spectrometry (MS) to investigate how S1782E influences MAP2 interactome.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jiali Lyu, Susan Erickson, Rebecca DeGiosio, Matthew MacDonald, Robert Sweet, Melanie Grubisha Source Type: research