The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295129240415120646. Online ahead of print.ABSTRACTRecently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs. We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring the staging of illness, l...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Michael Maes Source Type: research
Seasonal patterns in Chinese population: Validating the seasonal pattern assessment questionnaire and exploring associations with psychiatric diagnoses and biological rhythms
In this study, we enrolled 198 psychiatric patients with anxiety and depressive disorders (A&D), bipolar disorder (BD), and schizophrenia (SZ), as well as healthy college students. Online questionnaires, including the Seasonal Pattern Assessment Questionnaire (SPAQ) for seasonality, the Morningness and Eveningness Questionnaire-5 (MEQ-5) for chronotypes, and the Pittsburgh Sleep Quality Index (PSQI), were administered. The validity and reliability of the Chinese version of the SPAQ were thoroughly analyzed, revealing a Cronbach's alpha of 0.896 with a two-factor structure. Results indicated that higher seasonality was ...
Source: Chronobiology International - April 22, 2024 Category: Biology Authors: Huirong Luo Juan Cheng Zheng Zhang Yinlin Zhang Xueqian Wang Renqin Hu Junyao Li Yanwei Guo Qinghua Luo Source Type: research
The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295129240415120646. Online ahead of print.ABSTRACTRecently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs. We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring the staging of illness, l...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Michael Maes Source Type: research
Seasonal patterns in Chinese population: Validating the seasonal pattern assessment questionnaire and exploring associations with psychiatric diagnoses and biological rhythms
In this study, we enrolled 198 psychiatric patients with anxiety and depressive disorders (A&D), bipolar disorder (BD), and schizophrenia (SZ), as well as healthy college students. Online questionnaires, including the Seasonal Pattern Assessment Questionnaire (SPAQ) for seasonality, the Morningness and Eveningness Questionnaire-5 (MEQ-5) for chronotypes, and the Pittsburgh Sleep Quality Index (PSQI), were administered. The validity and reliability of the Chinese version of the SPAQ were thoroughly analyzed, revealing a Cronbach's alpha of 0.896 with a two-factor structure. Results indicated that higher seasonality was ...
Source: Chronobiology International - April 22, 2024 Category: Biology Authors: Huirong Luo Juan Cheng Zheng Zhang Yinlin Zhang Xueqian Wang Renqin Hu Junyao Li Yanwei Guo Qinghua Luo Source Type: research
The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295129240415120646. Online ahead of print.ABSTRACTRecently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs. We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring the staging of illness, l...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Michael Maes Source Type: research
The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295129240415120646. Online ahead of print.ABSTRACTRecently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs. We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring the staging of illness, l...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Michael Maes Source Type: research
Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
ConclusionLong-term SGAs medication inhibited osteogenesis in a dose- and time-dependent manner and damaged the balance of bone formation and bone resorption. (Source: Psychopharmacology)
Source: Psychopharmacology - April 22, 2024 Category: Psychiatry Source Type: research
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure
Translational Psychiatry, Published online: 22 April 2024; doi:10.1038/s41398-024-02910-2Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 22, 2024 Category: Psychiatry Authors: Xavier Caseras Emily Simmonds Antonio F. Pardi ñas Richard Anney Sophie E. Legge James T. R. Walters Neil A. Harrison Michael C. O ’Donovan Valentina Escott-Price Source Type: research
HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status
Bipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals ’ quality of life. The potential pro-inflammatory role in their pathoge... (Source: Retrovirology)
Source: Retrovirology - April 22, 2024 Category: Virology Authors: Sara Coelho Rangel, Michelly Damasceno da Silva, D écio Gilberto Natrielli Filho, Samuel Nascimento Santos, Jonatas Bussador do Amaral, Jefferson Russo Victor, Kevin Cezar Nascimento Silva, Izabela Dorota Tuleta, Carolina Nunes França, Marina Tiemi Shio Tags: Research Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial
Kobe J Med Sci. 2024 Apr 1;70(1):E15-E21. doi: 10.24546/0100488377.ABSTRACTTo clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-interve...
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Yuko Nishimura Kayano Yotsumoto Takeshi Hashimoto Source Type: research
