315. Development of a Predictive Model for Paliperidone Response Among Schizophrenia Subjects
Numerous randomized, double-blind, placebo-controlled trials have unequivocally demonstrated the efficacy of Paliperidone in addressing the complexities of schizophrenia. Despite these findings, the variability in individual responses to Paliperidone remains a significant consideration. This investigation seeks to delineate the influence of clinico-demographic and early-response features on Paliperidone drug response, serving as a fundamental pillar in the establishment of precision psychiatry. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mehrad Bastani, Pranay Mohanty, Xinghong Tang, Qingqin Li, Gayle Wittenberg Source Type: research
301. Investigating Mitochondrial Phenotypes of the Schizophrenia-Associated 22q10.2 Deletion Using Human Neural Models
Copy number variants (CNV) result in the removal or addition of genomic material. The 22q11.2 deletion (22qDel) confers 30-fold increased risk of developing schizophrenia. The 3-megabase deletion causes the hemizygosity of dozens of genes, including nine nuclear-encoded mitochondrial genes. However, little is known regarding the mechanisms of 22qDel mitochondrial phenotypes and their contribution to human cortical development. We hypothesize that the loss of mitochondrial genes within the 22q11.2 locus impacts mitochondria, thereby affecting neuronal development. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Maxine Robinette, Victor Faundez, Ryan Purcell, Gary Bassell Source Type: research
277. Permissive Parenting Mediates the Association Between Maternal Depression and Anhedonia in Children
Anhedonia, the inability to experience pleasure, has been gaining traction as one of the key neurobiological manifestations that underpin a range of psychiatric disorders, including depression and schizophrenia. Measures of anhedonia, rather than the overarching clinical diagnoses, could provide unique insights into the underlying neural and developmental pathways. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Aisleen M.A. Manahan, Shi Yu Chan, Zhen Ming Ngoh, Jasmine Chuah, Michael J. Meaney, Ai Peng Tan, Michelle Z.L. Kee, Pei Huang Source Type: research
175. Preliminary Data Suggests Repeated Electroconvulsive Shock Increases C-Fos Activation of Mouse Parvalbumin Interneurons in the Hippocampus and Prefrontal Cortex
Electroconvulsive therapy (ECT) has been used for more than 80 years as a highly effective treatment for drug-resistant psychiatric disorders such as depression, bipolar disorder, schizophrenia, and catatonia. Despite this treatment ’s remarkable efficacy, its mechanism of action remains unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Noah Kabbaj, Oliver J. Krentzman, John Bilbily, Jordan G. McCall Source Type: research
137. Toxoplasma Gondii IgG Serointensity in Seropositive Patients and Cognitive Function in Patients With Bipolar Disorder
Cognitive dysfunction is a major predictor of functional deterioration in bipolar disorder (BD), as previously reported in schizophrenia. Associations between Toxoplasma gondii (T.gondii) seropositivity and serointensity and cognitive dysfunction were found across diagnostic boundaries. In contrast to other conditions, no study has yet reported any significant association between T. gondii IgG serointensity and seropositivity (hallmarks of chronic latent infection) with cognitive function in BD, in part because mood state heterogeneity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mariam Mikadze, Paul Rensch, Nina Dalkner, Tatjana Stross, Niel Constantine, Aline Dagdag, Abhishek Wadhawan, Farooq Mohyuddin, Armin Birner, Frederike T. Fellendorf, Melanie Lenger, Alexander Maget, Annamaria Painold, Robert Queissner, Franziska Schmiedh Source Type: research
104. Modafinil Exerts Dose-Dependent Effects on Risk-Taking as Measured by the Human Iowa Gambling Task
Poor decision-making driving increased risk-taking is a hallmark symptom of many psychiatric disorders, quantifiable by the Iowa Gambling Task (IGT), and linked to real-world outcomes e.g., suicide and drug use. Identifying remediating treatments for people with such disorders (e.g., schizophrenia, bipolar disorder, HIV etc.), is vital toward improving their lives. Modafinil is an atypical stimulant that can improve cognition, but animal studies suggest high doses increase risk-taking. We hypothesized a dose-dependent effect of modafinil in risk-taking of healthy people such that higher doses would impair, while lower dose...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Samantha Ayoub, William Perry, Arpi Minassian, Jared Young Source Type: research
89. Shared Disruptions in Neural Circuits of Eye Gaze Processing in Autism Spectrum Disorder and Schizophrenia
Impairment in social cognition, particularly eye gaze processing, is a shared feature common to autism spectrum disorder (ASD) and schizophrenia. However, it is unclear if a convergent neural mechanism also underlies gaze dysfunction in these conditions. The present study examined whether this shared eye gaze phenotype is reflected in a profile of convergent neurobiological dysfunction in ASD and schizophrenia. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Karim Ibrahim, Iciar Iturmendi-Sabater, Maya Vasishth, Daniel S. Barron, MariaRose Guardavaccaro, Avram Holmes, Gregory McCarthy, Simon B. Eickhoff, Denis G. Sukhodolsky Source Type: research
86. Low Frequency Genetic Variants Orchestrate Genetic Vulnerability for Autism Spectrum Disorders and Schizophrenia in Concert With Rare and Common Variants
We found that a regional excess of genetic variants with minor allele frequencies (MAF) 1% and (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Elemi Breetvelt, Nickie Safarian, Worrawat Engchuan, Brett Trost, Marla Mendes de Aquino, Louise Gallagher, Stephen W. Scherer, Jacob Vorstman Source Type: research
504. Functional Connectome Fingerprinting in Schizophrenia - Replication in ECT Cohort
Finn et al. introduced a technique known as functional connectome fingerprinting, capable of distinguishing an individual from a large pool of subjects based on their fMRI functional connectome. In addition, Kaufmann showed that connectome distinctiveness decreased in individuals with increased clinical symptom scores (Kaufmann et al 2017). In the context of schizophrenia, numerous studies from various research groups consistently report a significant alteration in global brain connectivity and analogous nodal strength measures. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: M áté Baradits, Paul Masi, Georgios Petrides, Sohag N. Sanghani, Anil Malhotra, Miklós Argyelán Source Type: research
Abuse and Neglect of Children With Specific Learning Disorders in T ürkiye: A Case-Control Study
CONCLUSIONS: The presence of SLDs is a significant risk factor for children to be exposed to abuse even in the absence of ADHD as a comorbidity.PMID:38679965 | DOI:10.1002/cpp.2986 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 29, 2024 Category: Psychiatry Authors: Mehmet Erdem Uzun Yekta Ko şan Hande Şirin Source Type: research
Integrating Subjective Recovery and Stigma Resistance in Individuals with Schizophrenia: A Narrative Review and Theoretical Integration
Issues Ment Health Nurs. 2024 Apr 29:1-14. doi: 10.1080/01612840.2024.2341049. Online ahead of print.ABSTRACTStigmatised attitudes are known to be associated with negative outcomes in schizophrenia, yet there is little focus on the role of stigma in the recovery process. Attempts to develop interventions to reduce self-stigma in schizophrenia have not been found effective. This paper presents a theoretical integration based on a narrative review of the literature. PsycINFO, Medline and Embase databases were searched up to the 11th December 2023. Studies were included if they were: i) empirical studies using qualitative, qu...
Source: Issues in Mental Health Nursing - April 29, 2024 Category: Nursing Authors: Zosia Swistak MSc Susan Sookoo Ma Tom Jewell PhD Source Type: research
Abuse and Neglect of Children With Specific Learning Disorders in T ürkiye: A Case-Control Study
CONCLUSIONS: The presence of SLDs is a significant risk factor for children to be exposed to abuse even in the absence of ADHD as a comorbidity.PMID:38679965 | DOI:10.1002/cpp.2986 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 29, 2024 Category: Psychiatry Authors: Mehmet Erdem Uzun Yekta Ko şan Hande Şirin Source Type: research
The relationship between obsessive-compulsive symptoms and real-life functioning in schizophrenia: New insights from the multicenter study of the Italian Network for Research on Psychoses
Eur Psychiatry. 2024 Apr 29:1-31. doi: 10.1192/j.eurpsy.2024.1747. Online ahead of print.NO ABSTRACTPMID:38682575 | DOI:10.1192/j.eurpsy.2024.1747 (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - April 29, 2024 Category: Psychiatry Authors: Matteo Tonna Davide Fausto Borrelli Eugenio Aguglia Paola Bucci Bernardo Carpiniello Liliana Dell'Osso Andrea Fagiolini Paolo Meneguzzo Palmiero Monteleone Maurizio Pompili Rita Roncone Rodolfo Rossi Patrizia Zeppegno Carlo Marchesi Mario Maj Source Type: research
Can neurocognition, brain neurotrophic factor, triglyceride, and total cholesterol predict suicidal ideation in first ‐episode Han Chinese patients with schizophrenia?
ConclusionSerum BDNF level, PANSS score, and MCCB score can be used as auxiliary predictors of suicidal ideation in schizophrenic patients. Combining these three indicators can effectively predict suicidal ideation in schizophrenic patients. (Source: Brain and Behavior)
Source: Brain and Behavior - April 29, 2024 Category: Neurology Authors: Li Dongxia,
Ma Li,
Feng Yingying Tags: ORIGINAL ARTICLE Source Type: research
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia
Molecular Psychiatry, Published online: 29 April 2024; doi:10.1038/s41380-024-02568-8Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - April 29, 2024 Category: Psychiatry Authors: Angeliki Spathopoulou Gabriella A. Sauerwein Valentin Marteau Martina Podlesnic Theresa Lindlbauer Tobias Kipura Madlen Hotze Elisa Gabassi Katharina Kruszewski Marja Koskuvi J ános M. Réthelyi Ágota Apáti Luciano Conti Manching Ku Therese Koal Udo M Source Type: research
