Oral health of people with emotional disorders: A systematic review and meta-analysis
ConclusionPatients with schizophrenia and bipolar disorder exhibit increased frequency in the number of decayed, missing, or filled teeth. There was no effect in relation to periodontal probing depth, plaque index, and TMD, but the evidence is still uncertain for this outcome.Clinical relevanceThese findings underscore the need for a comprehensive health approach. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 26, 2024 Category: Dentistry Source Type: research
Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
Molecular Psychiatry, Published online: 26 April 2024; doi:10.1038/s41380-024-02563-zDifferences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - April 26, 2024 Category: Psychiatry Authors: Rachel J. Sharkey Chelsea Bacon Zeru Peterson Kelly Rootes-Murdy Raymond Salvador Edith Pomarol-Clotet Andriana Karuk Philipp Homan Ellen Ji Wolfgang Omlor Stephanie Homan Foivos Georgiadis Stefan Kaiser Matthias Kirschner Stefan Ehrlich Udo Dannlowski Do Source Type: research
Quality of life among people living with mental illness and predictors in Africa: a systematic review and meta-analysis
ConclusionsThe current systematic review and meta-analysis showed that almost half of patients with mental illness had poor QoL. Being illiterate, having a comorbid medical condition, having a low monthly income, having positive symptoms, and having negative symptoms of mental illness were independent predictors of poor QoL. This systematic review and meta-analysis emphasize that poor QoL of people with mental illness in Africa needs attention to reduce its negative consequences. (Source: Quality of Life Research)
Source: Quality of Life Research - April 25, 2024 Category: Health Management Source Type: research
A gene mutation turned these fish into intrepid explorers
The 240 species of cichlid fish in Africa’s Lake Tanganyika come in an astonishing variety of shapes and sizes, from the paper clip–size “sheller” that lives in abandoned snail shells to the nearly meter-long emperor cichlid. Biologists have long wondered what drove this burst of evolutionary creativity. Now, researchers have demonstrated what many suspected but had not been able to prove: that the behavior of an ancestral species—in this case, an appetite for exploration—set the stage for the rapid evolution.
The work, which appears today in
Science
, also
ties this behavioral trait to a...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Using Linkage-enhancement Strategies to Bridge Treatment Gap among Inmates and Former Inmates in Correctional Settings with Inadequate Mental Health Care
J Health Care Poor Underserved. 2024;35(1):116-131.ABSTRACTService linkage and skill enhancement strategies were devised in Nigerian prisons with inadequate mental health resources to support the provision of psycho-legal services, including the assessments, identification, and care of inmates and former inmates with mental illness. Over the study period, 74 individuals, consisting of 64 (86.5%) males with a mean age of 33.25 (SD=11.2) years received care or psycho-legal services through these strategies. Clinically, 49% of the participants were diagnosed with schizophrenia (International Classification of Diseases, Tenth ...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Andrew T Olagunju Oluyemi O Akanni Stephen O Oluwaniyi Ambrose O Lawani Michael O Olutoki Jeffrey Wang Olajide Adelugba Abdullah H Alqahtani John W Bradford Gary A Chaimowitz Source Type: research
HIV Viral Suppression Among Psychiatric Inpatients with Schizophrenia in San Francisco: A Retrospective Cohort Study
J Health Care Poor Underserved. 2024;35(1):1-7.ABSTRACTPeople with schizophrenia are at increased risk for contracting HIV and face higher mortality rates compared with the general population. Viral suppression is key to HIV care, yet little is known about this metric among people with HIV and schizophrenia. A chart review was conducted among people with HIV/AIDS and schizophrenia living in San Francisco who had received inpatient mental health services between 2010 and 2016. Demographic, laboratory, medication, encounter, and discharge data were collected, and were compared with all people living with HIV in San Francisco...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Nicholas S Riano Paul Wesson Eric Vittinghoff Francine Cournos James Dilley Christina Mangurian Source Type: research
The Risk and The Course of Cancer Among People with Severe Mental Illness
Clin Pract Epidemiol Ment Health. 2023 Dec 3;19(Suppl-1):e174501792301032. doi: 10.2174/17450179-v17-e211208-2021-HT2-1910-8. eCollection 2023.ABSTRACTThe paucity of data regarding patients with Serious Mental Illness (SMI) and cancer is alarming given the fact that people with SMI, especially schizophrenia, bipolar disorders and severe depressive disorders, have in general poorer access to physical health care and higher morbidity and mortality because of physical illnesses. The aims of this review were to examine the current evidence from existing literature on the risk of developing cancer and its course among people wi...
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Luigi Grassi Daniel McFarland Michelle Riba Source Type: research
Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia
We examined the association of rare or low-frequency deleterious coding variants in Chinese patients with SCZ. We collected DNA samples in 197 patients with SCZ spectrum disorder and 82 healthy controls (HC), and performed exome sequencing. The AAO variable was ascertained in the majority of SCZ participants for identify the early-onset (EOS, AAO<=18) and adult-onset (AOS, AAO>18) subgroups. We examined the overall association of rare/low-frequency, damaging variants in SCZ versus HC, EOS versus HC, and AOS versus HC at the gene and gene-set levels using Sequence Kernel Association Test. The quantitative rare-variant...
Source: Asian Journal of Psychiatry - April 25, 2024 Category: Psychiatry Authors: Yuanxin Zhong Justin D Tubbs Perry B M Leung Na Zhan Tomy C K Hui Karen K Y Ho Karen S Y Hung Eric F C Cheung Hon-Cheong So Simon S Y Lui Pak C Sham Source Type: research
Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia
This study aims to investigate the altered patterns of dynamic functional network connectivity (dFNC) between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and further explore the associations with cognitive impairments. 70 DS, 91 NDS, and 120 matched healthy controls (HCs) were enrolled. The independent component analysis was used to segment the whole brain. The fMRI brain atlas was used to identify functional networks, and the dynamic functional connectivity (FC) of each network was detected. Correlation analysis was used to explore the associations between altered dFNC and cognitive functions. Four dyn...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 25, 2024 Category: Psychiatry Authors: Biying Ye Yiqiao Wu Mingjun Cao Chanhuan Xu Chao Zhou Xiangrong Zhang Source Type: research
Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells
In this study, we evaluated the effect of aripiprazole on voltage-gated potassium (Kv) channels in rabbit coronary arterial smooth muscle cells using the patch clamp technique. Aripiprazole reduced the Kv current in a concentration-dependent manner with a half-maximal inhibitory concentration of 0.89 ± 0.20 μM and a Hill coefficient of 1.30 ± 0.25. The inhibitory effect of aripiprazole on Kv channels was voltage-dependent, and an additional aripiprazole-induced decrease in the Kv current was observed in the voltage range of full channel activation. The decay rate of Kv channel inactivation was accelerated by aripiprazol...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Minji Kang Seo-Yeong Mun Wenwen Zhuang Minju Park Junsu Jeong Hongzoo Park Won-Kyo Jung Il-Whan Choi Sunghun Na Won Sun Park Source Type: research
Using Linkage-enhancement Strategies to Bridge Treatment Gap among Inmates and Former Inmates in Correctional Settings with Inadequate Mental Health Care
J Health Care Poor Underserved. 2024;35(1):116-131.ABSTRACTService linkage and skill enhancement strategies were devised in Nigerian prisons with inadequate mental health resources to support the provision of psycho-legal services, including the assessments, identification, and care of inmates and former inmates with mental illness. Over the study period, 74 individuals, consisting of 64 (86.5%) males with a mean age of 33.25 (SD=11.2) years received care or psycho-legal services through these strategies. Clinically, 49% of the participants were diagnosed with schizophrenia (International Classification of Diseases, Tenth ...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Andrew T Olagunju Oluyemi O Akanni Stephen O Oluwaniyi Ambrose O Lawani Michael O Olutoki Jeffrey Wang Olajide Adelugba Abdullah H Alqahtani John W Bradford Gary A Chaimowitz Source Type: research
HIV Viral Suppression Among Psychiatric Inpatients with Schizophrenia in San Francisco: A Retrospective Cohort Study
J Health Care Poor Underserved. 2024;35(1):1-7.ABSTRACTPeople with schizophrenia are at increased risk for contracting HIV and face higher mortality rates compared with the general population. Viral suppression is key to HIV care, yet little is known about this metric among people with HIV and schizophrenia. A chart review was conducted among people with HIV/AIDS and schizophrenia living in San Francisco who had received inpatient mental health services between 2010 and 2016. Demographic, laboratory, medication, encounter, and discharge data were collected, and were compared with all people living with HIV in San Francisco...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Nicholas S Riano Paul Wesson Eric Vittinghoff Francine Cournos James Dilley Christina Mangurian Source Type: research
The Risk and The Course of Cancer Among People with Severe Mental Illness
Clin Pract Epidemiol Ment Health. 2023 Dec 3;19(Suppl-1):e174501792301032. doi: 10.2174/17450179-v17-e211208-2021-HT2-1910-8. eCollection 2023.ABSTRACTThe paucity of data regarding patients with Serious Mental Illness (SMI) and cancer is alarming given the fact that people with SMI, especially schizophrenia, bipolar disorders and severe depressive disorders, have in general poorer access to physical health care and higher morbidity and mortality because of physical illnesses. The aims of this review were to examine the current evidence from existing literature on the risk of developing cancer and its course among people wi...
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Luigi Grassi Daniel McFarland Michelle Riba Source Type: research
Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia
We examined the association of rare or low-frequency deleterious coding variants in Chinese patients with SCZ. We collected DNA samples in 197 patients with SCZ spectrum disorder and 82 healthy controls (HC), and performed exome sequencing. The AAO variable was ascertained in the majority of SCZ participants for identify the early-onset (EOS, AAO<=18) and adult-onset (AOS, AAO>18) subgroups. We examined the overall association of rare/low-frequency, damaging variants in SCZ versus HC, EOS versus HC, and AOS versus HC at the gene and gene-set levels using Sequence Kernel Association Test. The quantitative rare-variant...
Source: Asian Journal of Psychiatry - April 25, 2024 Category: Psychiatry Authors: Yuanxin Zhong Justin D Tubbs Perry B M Leung Na Zhan Tomy C K Hui Karen K Y Ho Karen S Y Hung Eric F C Cheung Hon-Cheong So Simon S Y Lui Pak C Sham Source Type: research
Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia
This study aims to investigate the altered patterns of dynamic functional network connectivity (dFNC) between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and further explore the associations with cognitive impairments. 70 DS, 91 NDS, and 120 matched healthy controls (HCs) were enrolled. The independent component analysis was used to segment the whole brain. The fMRI brain atlas was used to identify functional networks, and the dynamic functional connectivity (FC) of each network was detected. Correlation analysis was used to explore the associations between altered dFNC and cognitive functions. Four dyn...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 25, 2024 Category: Psychiatry Authors: Biying Ye Yiqiao Wu Mingjun Cao Chanhuan Xu Chao Zhou Xiangrong Zhang Source Type: research
