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Total 656 results found since Jan 2013.

Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment
CONCLUSIONS: Our data demonstrate resolution of inflammation is impaired by DM in AIS patients, implicating a novel mechanism of un-resolved inflammation in DM-related AIS. Furthermore, RvD2 promotes inflammation resolution in macrophages/microglia and protects DM-related AIS, and may thus serve as a novel therapeutic target.PMID:35750271 | DOI:10.1016/j.freeradbiomed.2022.06.231
Source: Free Radical Biology and Medicine - June 24, 2022 Category: Biology Authors: Xin Tang Lan Liu Zhijuan Miao Jiawei Zhang Xiaolong Cai Bing-Qiao Zhao Gefei Chen Marianne Schultzberg Yuwu Zhao Xiuzhe Wang Source Type: research

Deep learning-based behavioral profiling of rodent stroke recovery
Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in ro...
Source: BMC Biology - October 15, 2022 Category: Biology Authors: Rebecca Z. Weber, Geertje Mulders, Julia Kaiser, Christian Tackenberg and Ruslan Rust Tags: Methodology article Source Type: research

Efficacy of the Technologically Processed Antibodies to the Brain-Specific S100 Protein in a Rat Model of Hemorrhagic Stroke
We studied the ability of technologically processed antibodies to the brain-specific S100 protein (drug Prospekta) to reduce the brain lesion area, neurological disorders, and mortality in a rat model of hemorrhagic stroke. Technologically processed antibodies to S100 exerted a positive effect on all these parameters (brain lesion area, survival rate, neurological status according to the Menzies scale, and proportion of contralateral turns). This allows us to recommend further research into the spectrum of pharmacological activity and the mechanism of action of technologically processed antibodies to S100 in order to expan...
Source: Bulletin of Experimental Biology and Medicine - May 8, 2023 Category: Biology Source Type: research

Binding pocket dynamics along the recovery stroke of human β-cardiac myosin
by Fariha Akter, Julien Ochala, Arianna Fornili The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins. The breakthrough discovery of omecamtiv mecarbil (OM) has led to an increased interest in small molecules that can target myosin and modulate its function for therapeutic purposes (myosin modulators). In this work, we use a combination of computational methods, including steered molecular dynamics, umbrella sampling and binding pocket trackin...
Source: PLoS Computational Biology - May 18, 2023 Category: Biology Authors: Fariha Akter Source Type: research

Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
ConclusionsOur study demonstrates a clear sex pattern in age-related progression of renal and cardiac fibrosis and cellular senescence in SHRSP rats. A 6-week time frame was associated with increased indices of cardiac and renal fibrosis and cellular senescence in male SHRSPs. Female SHRSP rats were protected from renal and cardiac damage compared to age-matched males. Thus, the SHRSP is an ideal model to investigate the effects of sex and aging on organ injury over a short timeframe.
Source: Biology of Sex Differences - May 22, 2023 Category: Biology Source Type: research

Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
Source: Bulletin of Experimental Biology and Medicine - June 19, 2023 Category: Biology Source Type: research

Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia Research Communications
Toll-like receptor 4 (TLR4) mediates brain damage after stroke. Now our objective is to determine TLR4 involvement in stroke-induced neurogenesis. Stroke was induced by permanent middle cerebral artery occlusion in wild-type and TLR4-deficient mice. Stereological and densitometric analysis of immunofluorescence-labeled brain sections and FACS analysis of cell suspensions were performed. Our results show that subventricular zone (SVZ) cell proliferation after stroke depends on infarct size. Second, when comparing brains with similar lesions, TLR4 attenuated SVZ proliferation, as shown by a decrease in prominin-1+/EGFR+/nest...
Source: FASEB Journal - October 30, 2014 Category: Biology Authors: Moraga, A., Pradillo, J. M., Cuartero, M. I., Hernandez-Jimenez, M., Oses, M., Moro, M. A., Lizasoain, I. Tags: Research Communications Source Type: research

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage
The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma. In vitro, HTf was found to boost ROS production and to be harmful to primary neuronal cultures exposed to oxygen and glucose deprivation. In stroked rats, whereas increasing TSAT with exogenous HTf was detrimental, admin...
Source: Redox Biology - December 14, 2017 Category: Biology Source Type: research

Data-driven analyses of motor impairments in animal models of neurological disorders
by Hardeep Ryait, Edgar Bermudez-Contreras, Matthew Harvey, Jamshid Faraji, Behroo Mirza Agha, Andrea Gomez-Palacio Schjetnan, Aaron Gruber, Jon Doan, Majid Mohajerani, Gerlinde A. S. Metz, Ian Q. Whishaw, Artur Luczak Behavior provides important insights into neuronal processes. For example, analysis of reaching movements can give a reliable indication of the degree of impairment in neurological disorders such as stroke, Parkinson disease, or Huntington disease. The analysis of such movement abnormalities is no toriously difficult and requires a trained evaluator. Here, we show that a deep neural network is able to score...
Source: PLoS Biology: Archived Table of Contents - November 20, 2019 Category: Biology Authors: Hardeep Ryait Source Type: research

A mathematical model of the carp heart ventricle during the cardiac cycle
Publication date: 21 May 2015 Source:Journal of Theoretical Biology, Volume 373 Author(s): Petra Kochová , Robert Cimrman , Milan Štengl , Bohuslav Ošťádal , Zbyněk Tonar The poikilothermic heart has been suggested as a model for studying some of the mechanisms of early postnatal mammalian heart adaptations. We assessed morphological parameters of the carp heart (Cyprinus carpio L.) with diastolic dimensions: heart radius (5.73mm), thickness of the compact (0.50mm) and spongy myocardium (4.34mm), in two conditions (systole, diastole): volume fraction of the compact myocardium (20.7% systole, 19.6% diastole), spongy...
Source: Journal of Theoretical Biology - March 31, 2015 Category: Biology Source Type: research

A meta-analysis of in vivo vertebrate cardiac performance: implications for cardiovascular support in the evolution of endothermy RESEARCH ARTICLE
Stanley S. Hillman and Michael S. Hedrick Endothermy in birds and mammals is associated with high body temperatures, and high rates of metabolism that are aerobically supported by elevated rates of cardiovascular O2 transport. The purpose of this meta-analysis was to examine cardiovascular data from ectothermic and endothermic vertebrates, at rest and during exercise, with the goal of identifying key variables that may have contributed to the role of the cardiovascular system in supporting high rates of O2 transport associated with endothermy. Vascular conductance, cardiac power and stroke work were summarized and calculat...
Source: Journal of Experimental Biology - April 22, 2015 Category: Biology Authors: Hillman, S. S., Hedrick, M. S. Tags: RESEARCH ARTICLE Source Type: research

Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations
by Shintaroh Kubo, Wenfei Li, Shoji Takada Cytoplasmic dynein is a giant ATP-driven molecular motor that proceeds to the minus end of the microtubule (MT). Dynein hydrolyzes ATP in a ring-like structure, containing 6 AAA+ (ATPases associated with diverse cellular activities) modules, which is ~15 nm away from the MT binding domain (MTBD). This architecture implies that long-distance allosteric couplings exist between the AAA+ ring and the MTBD in order for dynein to move on the MT, although little is known about the mechanisms involved. Here, we have performed comprehensive molecular simulations of the dynein motor domain...
Source: PLoS Computational Biology - September 11, 2017 Category: Biology Authors: Shintaroh Kubo Source Type: research

Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia
Publication date: 15 February 2018 Source:Life Sciences, Volume 195 Author(s): Sara Jane Ward, Francesca Castelli, Zachary W. Reichenbach, Ronald F. Tuma Aims We tested the hypothesis that CB1/CB2 receptor double knockout would produce significant increases in infarct size and volume and significant worsening in clinical score, using two mouse models, one of permanent ischemia and one of ischemia/reperfusion. Main methods Focal cerebral infarcts were created using either photo induced permanent injury or transient middle cerebral artery occlusion. Infarct volume and motor function were evaluated in cannabinoid receptor 1/...
Source: Life Sciences - January 5, 2018 Category: Biology Source Type: research

The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress.
Abstract Diabetes, a risk factor for stroke, leads to elevated blood methylglyoxal (MG) levels. This is due to increased MG generation from the high glucose levels, and because diabetes impairs the glutathione (GSH)-glyoxalase system for MG elimination. MG glycates proteins and causes dicarbonyl stress. We investigated the contribution of MG and GSH to stroke outcome. Cerebral ischemia/reperfusion was performed in chemical-induced (streptozotocin) and genetic Akita mouse models of Type 1 diabetes. Brain infarction and functions of the GSH-dependent MG elimination pathway were determined. Diabetes increased post-is...
Source: Free Radical Biology and Medicine - April 11, 2016 Category: Biology Authors: Wang B, Yee Aw T, Stokes KY Tags: Free Radic Biol Med Source Type: research

Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project.
This article describes the rationale, objectives, design and conduct of the ambulatory blood pressure monitoring (ABPM)-based Hygia Project. Given the substantial evidence of the significantly better prognostic value of ABPM compared to clinic BP measurements, several international guidelines now propose ABPM as a requirement to confirm the office diagnosis of hypertension. Nonetheless, all previous ABPM outcome investigations, except the Monitorización Ambulatoria para Predicción de Eventos Cardiovasculares study (MAPEC) study, relied upon only a single, low-reproducible 24 h ABPM assessment per participant done at stud...
Source: Chronobiology International - May 23, 2016 Category: Biology Authors: Hermida RC Tags: Chronobiol Int Source Type: research