Filtered By:
Specialty: Biology

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 656 results found since Jan 2013.

Hypoxia inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Abstract Neurologic conditions including stroke, Alzheimer's disease, Parkinson's disease and Huntington's disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions have historically had poor success in translating from bench to bedside. Hypoxia Inducible Factor-1alpha (HIF-1α) mediates a broad, evolutionarily conserved, endogenous adaptive program to hypoxia, and manipulation of components of the HIF pathway are neuroprotective in a number of human neurological diseases and experimental models. In this review, we discuss mole...
Source: Free Radical Biology and Medicine - January 31, 2013 Category: Biology Authors: Speer RE, Karuppagounder SS, Basso M, Sleiman S, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR Tags: Free Radic Biol Med Source Type: research

Autologous stem cell therapy improves motor function in chronic stroke victims
(Cell Transplantation Center of Excellence for Aging and Brain Repair) One group of chronic stroke victims had their peripheral blood stem cells injected directly into the brain while another group did not. Those in the peripheral blood stem cell-injected group also received G-CSF, known to be potentially neuroprotective. Those receiving the peripheral blood stem cells experienced some improvement in stroke scales and functional outcome. The study provided first evidence that intracerebral injection of autologous peripheral blood stem cells can improve motor function in those who have suffered prior strokes and have motor deficits.
Source: EurekAlert! - Biology - April 23, 2014 Category: Biology Source Type: news

Evaluating cardiac physiology through echocardiography in bottlenose dolphins: using stroke volume and cardiac output to estimate systolic left ventricular function during rest and following exercise RESEARCH ARTICLE
S. Miedler, A. Fahlman, M. Valls Torres, T. Alvaro Alvarez, and D. Garcia-ParragaHeart-rate (fH) changes during diving and exercise are well documented for marine mammals, but changes in stroke volume (SV) and cardiac output (CO) are much less known. We hypothesized that both SV and CO are also modified following intense exercise. Using transthoracic ultrasound Doppler at the level of the aortic valve, we compared blood flow velocities in the left ventricle and cardiac frequencies during rest and at 1, 3 and 4 min after a bout of exercise in 13 adult bottlenose dolphins (Tursiops truncatus, six male and seven female, body ...
Source: Journal of Experimental Biology - September 18, 2015 Category: Biology Authors: Miedler, S., Fahlman, A., Valls Torres, M., Alvaro Alvarez, T., Garcia-Parraga, D. Tags: RESEARCH ARTICLE Source Type: research

Sweeping review of human genome IDs stroke risk genes
(University of Virginia Health System) Researchers seeking to better understand how our genes contribute to stroke risk have completed what is believed to be the largest and most comprehensive review of the human genome to identify genes that predispose people to ischemic stroke, the cause of approximately 85 percent of all strokes.
Source: EurekAlert! - Biology - February 29, 2016 Category: Biology Source Type: news

Electroacupunctre improves motor impairment via inhibition of microglia-mediated neuroinflammation in the sensorimotor cortex after ischemic stroke
Publication date: Available online 14 March 2016 Source:Life Sciences Author(s): Weilin Liu, Xian Wang, Shanli Yang, Jia Huang, Xiehua Xue, Yi Zheng, Guanhao Shang, Jing Tao, Lidian Chen Aims Electroacupuncture (EA) is one of the safety and effective therapies for improving neurological and sensorimotor impairment via blockade of inappropriate inflammatory responses. However, the mechanisms of anti-inflammation involved is far from been fully elucidated. Main methods Focal cerebral ischemic stroke was administered by the middle cerebral artery occlusion and reperfusion (MCAO/R) surgery. The MCAO/R rats were acc...
Source: Life Sciences - March 14, 2016 Category: Biology Source Type: research

Scientists confirm correlation between malignant hyperthermia and exertional heat stroke
(Federation of American Societies for Experimental Biology) New research published online in The FASEB Journal may ultimately help athletes and trainers better understand who may be more at risk for heat stroke. In the report, scientists use animals to show that there is a link between the susceptibility to malignant hyperthermia (MH) and exertional heat stroke.
Source: EurekAlert! - Biology - May 11, 2017 Category: Biology Source Type: news

Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model
This study aims to explore the role of fractalkine/CX3C chemokine receptor 1 (CX3CR1) signaling pathway in the recovery of neurological functioning after an early ischemic stroke in rats. After establishment of permanent middle cerebral artery occlusion (pMCAO) models, 50 rats were divided into blank, sham, model, positive control and CX3CR1 inhibitor groups. Neurological impairment, walking and grip abilities, and cortical and hippocampal infarctions were evaluated by Zea Longa scoring criterion, beam-walking assay and grip strength test, and diffusion-weighted magnetic resonance imaging. qRT-PCR and Western blotting were...
Source: Life Sciences - July 19, 2017 Category: Biology Source Type: research

Molecular genetic studies in Saudi population; identified variants from GWAS and Meta-analysis in Stroke
Conclusion The results of the current study confirmed the SORT1 and OLR1 SNPs were associated in the Saudi population. The current results were in the association with the prior study results documented through GWAS and meta-analysis association. However, other ethnic population studies should be performed to rule out in the human hereditary diseases.
Source: Saudi Journal of Biological Sciences - August 24, 2017 Category: Biology Source Type: research

Biomechanical mechanisms underlying exosuit-induced improvements in walking economy after stroke RESEARCH ARTICLE
This study elucidates the biomechanical mechanisms underlying exosuit-induced reductions in metabolic power. We evaluated the relationships between exosuit-induced changes in the body center of mass (COM) power generated by each limb, individual joint powers, and metabolic power. Compared to walking with an exosuit unpowered, exosuit assistance produced more symmetrical COM power generation during the critical period of the step-to-step transition (22.4±6.4% more symmetric). Changes in individual limb COM power were related to changes in paretic (R2= 0.83, P= 0.004) and nonparetic (R2= 0.73, P= 0.014) ankle power. I...
Source: Journal of Experimental Biology - January 18, 2018 Category: Biology Authors: Bae, J., Awad, L. N., Long, A., O'Donnell, K., Hendron, K., Holt, K. G., Ellis, T. D., Walsh, C. J. Tags: RESEARCH ARTICLE Source Type: research

Prospects of Synchronous fMRI-EEG Recording as the Basis for Neurofeedback (Exemplified on Patient with Stroke Sequelae)
Synchronous fMRI-EEG mapping of cerebral activity in stroke patients made it possible to implement neurofeedback, a novel and promising therapeutic technology. This method integrates a real-time monitoring of cerebral activity by EEG and fMRI signals and training of the patients to control this activity simultaneously or alternatively via neurofeedback. The targets of such cerebral stimulation are cortical regions controlling arbitrary movements (Brodmann area 4), whereas its aim is optimization of activity in these regions in order to achieve better rehabilitation of stroke patients. The paper discusses the methodical det...
Source: Bulletin of Experimental Biology and Medicine - January 9, 2019 Category: Biology Source Type: research

Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke in Rats with Different Behavioral Activity
Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the development of motor disturbances in the forelimb use asymmetry test and corner rotation paradigm. These animals preferred to use the left forelimb (ipsilateral to the side of hemorrhage) to lean on the cylinder wall. The frequency of using the right forelimb or both forelimbs was reduced under these conditions. The ...
Source: Bulletin of Experimental Biology and Medicine - April 23, 2019 Category: Biology Source Type: research

Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model
Publication date: Available online 4 July 2019Source: Journal of Thermal BiologyAuthor(s): Yannick Lutz, Axel Loewe, Stephan Meckel, Olaf Dössel, Giorgio CattaneoAbstractLocal brain hypothermia is an attractive method for providing cerebral neuroprotection for ischemic stroke patients and at the same time reducing systemic side effects of cooling. In acute ischemic stroke patients with large vessel occlusion, combination with endovascular mechanical recanalization treatment could potentially allow for an alleviation of inflammatory and apoptotic pathways in the critical phase of reperfusion. The direct cooling of arterial...
Source: Journal of Thermal Biology - July 6, 2019 Category: Biology Source Type: research

Harnessing the microbiome to improve stroke recovery
(Society for Neuroscience) Supplementing the body's short chain fatty acids can improve stroke recovery, according to research in mice recently published in JNeurosci. Short chain fatty acid supplementation may be a noninvasive addition to stroke rehabilitation therapies.
Source: EurekAlert! - Biology - January 2, 2020 Category: Biology Source Type: news

Kessler Foundation tests digital therapeutic approach to improve walking after stroke
(Kessler Foundation) 'Loss of mobility after stroke exerts a huge toll on individuals, their caregivers, our healthcare system, and society,' said Dr. Nolan, site investigator for the Kessler site. 'Stroke rehabilitation is an area where we need to test new technologies to change the outlook for recovery. Applying digital therapeutics is a promising approach for restoring lost mobility,' she noted, 'which may foster greater independence and better quality of life in this population.'
Source: EurekAlert! - Biology - September 16, 2020 Category: Biology Source Type: news

Interrelations of Cerebral Hemodynamics with Parameters of Cardiac Function and Brain Tissue in Patients with Ischemic Stroke
We analyzed interrelations between the cerebral blood flow, cardiac output, and condition of the brain substance in 530 patients with ischemic stroke. Dependencies between the linear blood flow velocities in all arteries supplying the brain, as well as between the total volume blood flow through the internal carotid arteries and left ventricular stroke volume were revealed. The severity of atrophy was maximum in the parietal lobes (median 1.5 (1.0; 2.0)) and minimum in the occipital lobes (median 0.5 (0; 1.0)). Temporal lobes cortical atrophy significantly correlated with changes in the limbic system and in the periventric...
Source: Bulletin of Experimental Biology and Medicine - July 23, 2021 Category: Biology Source Type: research