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Total 656 results found since Jan 2013.

Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage: a register-based study
ConclusionsA lower proportion of women had good functioning, a difference that remained in IS after adjustments for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity. The amount of received hospital care was lower for women after adjustments. Whether shorter hospital stay results in lower function or is a consequence of lower function cannot be elucidated. One-year survival was higher in men when no adjustments were made but lower after adjustments. This likely reflects that women were older at time of stroke, had more severe strokes, and more disability pre-stroke —factors that make a ...
Source: Biology of Sex Differences - March 7, 2018 Category: Biology Source Type: research

No association of moon phase with stroke occurrence.
Abstract Stroke occurrence shows strong correlations with sleep disorders and even subtle sleep disturbances have been shown to affect ischemic stroke (IS) occurrence. Chronobiology also exerts effects, like the morning surge in IS occurrence. Lunar cycles have also been shown to affect sleep and other physiological processes, but studies on moon phases and its possible association with occurrence of stroke are rare and nonconclusive. Therefore, we studied the effects of moon phases on stroke hospitalizations and in-hospital mortality nationwide in Finland in 2004-2014. All patients aged ≥18 years with IS or in...
Source: Chronobiology International - May 23, 2018 Category: Biology Authors: Ruuskanen JO, Sipilä JOT, Rautava P, Kytö V Tags: Chronobiol Int Source Type: research

Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Abstract Ischemic stroke is one of the leading causes of death and disability worldwide. This acute vascular event interferes with blood supply to the brain and induces a burst of free radicals such as nitric oxide and superoxide, producing peroxynitrite, a precursor of strong nitrating agents. Fibrinogen is one of the most abundant plasma proteins; it plays a role in the hemostatic system, mediating clot formation, which can be affected by nitrotyrosine formation. We hypothesized that nitration of fibrinogen by ONOOH and ONOOCO2- radical products could be one of the early events of the ischemic stroke, and protei...
Source: Free Radical Biology and Medicine - February 3, 2021 Category: Biology Authors: Medeiros R, Sousa B, Rossi S, Afonso C, Bonino L, Pitt A, López E, Spickett C, Borthagaray G Tags: Free Radic Biol Med Source Type: research

Down-regulation of MIF by NF{kappa}B under hypoxia accelerated neuronal loss during stroke Research Communications
In this study, we showed that MIF expression is down-regulated by 0.75 ± 0.10-fold of the control in the infarct area in the mouse brains. Two functional cis-acing NFB response elements were identified in the human MIF promoter. Dual activation of hypoxia and NFB signaling resulted in significant reduction of MIF promoter activity to 0.86 ± 0.01-fold of the control. Furthermore, MIF reduced caspase-3 activation and protected neurons from oxidative stress- and in vitro ischemia/reperfusion-induced apoptosis. H2O2 significantly induced cell death with 12.81 ± 0.58-fold increase of TUNEL-positive cells, a...
Source: FASEB Journal - September 30, 2014 Category: Biology Authors: Zhang, S., Zis, O., Ly, P. T. T., Wu, Y., Zhang, S., Zhang, M., Cai, F., Bucala, R., Shyu, W.-C., Song, W. Tags: Research Communications Source Type: research

Sex differences and the role of IL-10 in ischemic stroke recovery
In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent predictor of functional outcomes. This suggests that higher serum IL-10 levels may reflect factors that interact with sex such as age and stroke severity.
Source: Biology of Sex Differences - October 12, 2015 Category: Biology Source Type: research

A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
CONCLUSION: This study suggests that the polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population. Further studies on the gene-gene and gene-environment interactions for the PDGFD gene and ischaemic stroke are needed. PMID: 26362023 [PubMed - in process]
Source: Annals of Human Biology - February 13, 2016 Category: Biology Tags: Ann Hum Biol Source Type: research

Robot-assisted mechanical therapy attenuates stroke-induced limb skeletal muscle injury Research
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted mechanical therapy (RAMT) device to objectively address the significance of mechanical physiotherapy on poststroke outcomes. Wistar rats were subjected to right hemisphere middle-cerebral artery occlusion and reperfusion. After 24 h, rats were split into control (RAMT–) or RAMT+ groups (30 min daily RAMT over the stroke-affected gastrocnemius) and were followed up to postst...
Source: FASEB Journal - February 27, 2017 Category: Biology Authors: Sen, C. K., Khanna, S., Harris, H., Stewart, R., Balch, M., Heigel, M., Teplitsky, S., Gnyawali, S., Rink, C. Tags: Research Source Type: research

Diverse roles of mitochondria in ischemic stroke
Publication date: June 2018 Source:Redox Biology, Volume 16 Author(s): Jenq-Lin Yang, Sujira Mukda, Shang-Der Chen Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of st...
Source: Redox Biology - March 15, 2018 Category: Biology Source Type: research

Mitochondria as a therapeutic target for ischemic stroke.
Abstract Stroke is the leading cause of death and physical disability worldwide. Mitochondrial dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes to the pathology of ischemia and reperfusion. Mitochondria is essential in promoting neural survival and neurological improvement following ischemic stroke. Therefore, mitochondria represent an important drug target for stroke treatment. This review discusses the mitochondrial molecular mechanisms underlying cerebral ischemia and involved in reactive oxygen species generation, mitochondrial electron transport dysfunction, mitochond...
Source: Free Radical Biology and Medicine - November 4, 2019 Category: Biology Authors: He Z, Ning N, Zhou Q, Khoshnam SE, Farzaneh M Tags: Free Radic Biol Med Source Type: research

Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria
Free Radic Biol Med. 2022 Mar 24:S0891-5849(22)00123-X. doi: 10.1016/j.freeradbiomed.2022.03.020. Online ahead of print.ABSTRACTIschemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for the progesterone receptor in exerting its potent birth control and hormone replacement therapy. Accumulating evidence implicates a new utility of Nestorone in affording neuroprotection in a variety of central nervous system diseases, including stroke. However, the mechanism o...
Source: Free Radical Biology and Medicine - March 28, 2022 Category: Biology Authors: Jea-Young Lee Vanessa Castelli Narender Kumar Regine Sitruk-Ware Cesario V Borlongan Source Type: research

Association Between Blood Selenium Levels and Stroke: A Study Based on the NHANES (2011-2018)
Biol Trace Elem Res. 2023 Apr 1. doi: 10.1007/s12011-023-03649-5. Online ahead of print.ABSTRACTAt present, the association between circulating selenium and stroke is still in dispute. Thus, this study aimed to ascertain the association with a larger sample size than the previous study, based on the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. In total, 13755 adults over the age of 20 years were included in our study. Multivariate logistic regression models were applied to analyze the correlation between blood selenium levels and stroke. The smooth curve fitting was performed to test the dos...
Source: Biological Trace Element Research - April 2, 2023 Category: Biology Authors: Kunsheng Zhao Yun Zhang Wenhai Sui Source Type: research

Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke.
In conclusion, we propose that pharmacological or dietary interventions aimed to precondition the brain via activation of the Nrf2 defense pathway in the cerebral microvasculature provides a novel therapeutic approach to prevent BBB breakdown and neurological dysfunction in stroke. PMID: 24017972 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - September 6, 2013 Category: Biology Authors: Alfieri A, Srivastava S, Siow RC, Cash D, Modo M, Duchen MR, Fraser PA, Williams SC, Mann GE Tags: Free Radic Biol Med Source Type: research

Stroke-attributable death among older persons during the great recession.
Abstract Epidemiological evidence indicates an elevated risk for stroke among stressed persons, in general, and among individuals who have lost their job, in particular. We, therefore, tested the hypothesis that stroke accounted for a larger fraction of deaths during the Great Recession than expected from other deaths and from trends, cycles, and other forms of autocorrelation. Based on vital statistics death data from California spanning 132 months from January 2000 through December 2010, we found support for the hypothesis. These findings appear attributable to non-Hispanic white men, who experienced a 5% increa...
Source: Economics and Human Biology - December 12, 2015 Category: Biology Authors: Falconi A, Gemmill A, Karasek D, Goodman J, Anderson B, Lee M, Bellows B, Catalano R Tags: Econ Hum Biol Source Type: research

Flipper stroke rate and venous oxygen levels in free-ranging California sea lions RESEARCH ARTICLE
Michael S. Tift, Luis A. Hückstädt, Birgitte I. McDonald, Philip H. Thorson, and Paul J. Ponganis The depletion rate of the blood oxygen store, development of hypoxemia, and dive capacity are dependent on the distribution and rate of blood oxygen delivery to tissues while diving. Although blood oxygen extraction by working muscle would increase the blood oxygen depletion rate in a swimming animal, there is little information on the relationship between muscle workload and blood oxygen depletion during dives. Therefore, we examined flipper stroke rate, a proxy of muscle workload, and posterior vena cava oxyg...
Source: Journal of Experimental Biology - February 5, 2017 Category: Biology Authors: Tift, M. S., Hückstädt, L. A., McDonald, B. I., Thorson, P. H., Ponganis, P. J. Tags: RESEARCH ARTICLE Source Type: research