Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke.

In conclusion, we propose that pharmacological or dietary interventions aimed to precondition the brain via activation of the Nrf2 defense pathway in the cerebral microvasculature provides a novel therapeutic approach to prevent BBB breakdown and neurological dysfunction in stroke. PMID: 24017972 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24017972?dopt=Abstract

Source: Free Radical Biology and Medicine - September 6, 2013 Category: Biology Authors: Alfieri A, Srivastava S, Siow RC, Cash D, Modo M, Duchen MR, Fraser PA, Williams SC, Mann GE Tags: Free Radic Biol Med Source Type: research