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Total 656 results found since Jan 2013.
Development of a Reactive Oxygen Species-Sensitive Nitric Oxide Synthase Inhibitor for the Treatment of Ischemic Stroke.
In this study, the nitrone 5was designed such that its decomposition product is a NOS inhibitor, 6, effectively leading to NOS inhibition specifically at the site of ROS production. The ability of 5to spin-trap radicals and decompose to 6 was observed using EPR and LC-MS/MS. The pro-drug concept was tested in vitro by measuring cell viability and 6 formation in SH-SY5Y cells subjected to oxygen glucose deprivation (OGD). 5 was found to be more efficacious and more potent than PBN, and was able to increase phospho-Akt while reducing nitrotyrosine and cleaved caspase-3 levels. 6 treatment, but not 5, was found to decrease NO...
Source: Free Radical Biology and Medicine - December 21, 2017 Category: Biology Authors: Nash KM, Schiefer IT, Shah ZA Tags: Free Radic Biol Med Source Type: research
Biomechanical mechanisms underlying exosuit-induced improvements in walking economy after stroke RESEARCH ARTICLE
This study elucidates the biomechanical mechanisms underlying exosuit-induced reductions in metabolic power. We evaluated the relationships between exosuit-induced changes in the body center of mass (COM) power generated by each limb, individual joint power and metabolic power. Compared with walking with an exosuit unpowered, exosuit assistance produced more symmetrical COM power generation during the critical period of the step-to-step transition (22.4±6.4% more symmetric). Changes in individual limb COM power were related to changes in paretic (R2=0.83, P=0.004) and non-paretic (R2=0.73, P=0.014) ankle power. Inte...
Source: Journal of Experimental Biology - March 7, 2018 Category: Biology Authors: Bae, J., Awad, L. N., Long, A., O'Donnell, K., Hendron, K., Holt, K. G., Ellis, T. D., Walsh, C. J. Tags: Comparative biomechanics of movement RESEARCH ARTICLE Source Type: research
Mediterranean-style diet may lower women's stroke risk
(University of East Anglia) Following a Mediterranean-style diet may reduce stroke risk in women over 40 but not in men -- according to new research led by the University of East Anglia.A new report, published today in the American Heart Association's journal Stroke, reveals that a diet high in fish, fruit, vegetables, nuts and beans, and lower in meat and dairy, reduces stroke risk among white adults who are at high risk of cardiovascular disease.
Source: EurekAlert! - Biology - September 20, 2018 Category: Biology Source Type: news
Dynamics of fMRI and EEG Parameters in a Stroke Patient Assessed during a Neurofeedback Course Focused on Brodmann Area 4 (M1)
A course of interactive stimulation of primary motor cortex (Brodmann area 4) in the brain of a stroke patient resulted in recovery of locomotion volume in the paretic extremities and in improvement of general health accompanied with diverse changes in cerebral activity. During the training course, the magnitude of response in the visual fields of Brodmann areas 17 and 18 decreased; in parallel, the motor areas were supplemented with other ones such as area 24 (the ventral surface ofanterior cingulate gyrus responsible for self-regulation of human brain activity and implicated into synthesis of tactile and special informat...
Source: Bulletin of Experimental Biology and Medicine - January 9, 2019 Category: Biology Source Type: research
Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3 β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway.
In this study, we investigated the effect and mechanism of Roflu against ischemic stroke using in vitro oxygen-glucose deprivation reperfusion (OGD/R) and in vivo rat middle cerebral artery occlusion (MCAO) models. We demonstrated that Roflu significantly reduced the apoptosis of HT-22 cells exposed to OGD/R, enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf-2), and reduced oxidative stress. Treatment with Roflu increased the phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β) but decreased the level of phosphorylated inositol requiring enzyme 1α (IRE1α...
Source: Free Radical Biology and Medicine - December 24, 2020 Category: Biology Authors: Xu B, Xu J, Cai N, Li M, Liu L, Qin Y, Li X, Wang H Tags: Free Radic Biol Med Source Type: research
Association Between Serum Copper and Stroke Risk Factors in Adults: Evidence from the National Health and Nutrition Examination Survey, 2011-2016
This study aimed to examine the relationships between serum copper and lipid levels among 3425 participants aged 20 years and older from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Data on administered questionnaires, serum copper concentrations, and lipid levels (total cholesterol, HDL cholesterol, triglycerides, and LDL cholesterol) were used. Associations between serum copper and lipid levels were evaluated using both multivariable linear regression and logistic regression models. In the linear regression models, total cholesterol and LDL cholesterol levels increased with increasing copper c...
Source: Biological Trace Element Research - May 6, 2021 Category: Biology Authors: Jingang Xu Guofeng Xu Junkang Fang Source Type: research
Application of fMRI and Simultaneous fMRI-EEG Neurofeedback in Post-Stroke Motor Rehabilitation
This article discusses the contribution of fMRI- and fMRI-EEG-neurofeedback into recovery of motor function in two subacute stroke patients during the early post-stroke period. Premotor and supplementary motor zones of the cortex were chosen as the targets of voluntary control. Patient 1 received 6 sessions of motor imagery-based fMRI neurofeedback of secondary motor areas activity and Patient 2 received a similar course with the addition of μ- and β-EEG activity suppression. Both reduced the motor deficit severity, improved on the quality of life, and increased the C3/C4 coherence to other central leads within EEG μ-ba...
Source: Bulletin of Experimental Biology and Medicine - July 22, 2021 Category: Biology Source Type: research
Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway
CONCLUSION: Our results support that Nrf2 is critical for Sfn-afforded neuroprotection after ischemic stroke. Thus, targeting Nrf2 may be a promising strategy for the treatment of PSCI.PMID:36244590 | DOI:10.1016/j.freeradbiomed.2022.10.001
Source: Free Radical Biology and Medicine - October 16, 2022 Category: Biology Authors: Qianqian Li George Fadoul Milos Ikonomovic Tuo Yang Feng Zhang Source Type: research
Lithium Co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3 β activity in a rat model
Free Radic Biol Med. 2023 Jul 4:S0891-5849(23)00522-1. doi: 10.1016/j.freeradbiomed.2023.07.004. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. Middle-aged male rats were subjected to transient global cerebral ischemia-reperfusion. NORT and Y-maze were used to assess the cognitive process...
Source: Free Radical Biology and Medicine - July 6, 2023 Category: Biology Authors: Anil Kumar Rana Rajneesh Kumar Durgesh Nandan Shukla Damanpreet Singh Source Type: research
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization
by Pinyi Liu, Yan Chen, Zhi Zhang, Zengqiang Yuan, Jian-Guang Sun, Shengnan Xia, Xiang Cao, Jian Chen, Cun-Jin Zhang, Yanting Chen, Hui Zhan, Yuexinzi Jin, Xinyu Bao, Yue Gu, Meijuan Zhang, Yun Xu
Microglia-mediated neuroinflammation is involved in various neurological diseases, including ischemic stroke, but the endogenous mechanisms preventing unstrained inflammation is still unclear. The anti-inflammatory role of transcription factor nuclear receptor subfamily 4 group A member 1 (NR4A1) in macrophages and microglia has previously been identified. However, the endogenous mechanisms that how NR4A1 restricts unstrained in...
Source: PLoS Biology: Archived Table of Contents - July 24, 2023 Category: Biology Authors: Pinyi Liu Source Type: research
Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide
Free Radic Biol Med. 2023 Aug 3:S0891-5849(23)00576-2. doi: 10.1016/j.freeradbiomed.2023.08.004. Online ahead of print.ABSTRACTDiabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to more severe consequences. However, the mechanism whereby the hyperglycemic status in diabetes affects biochemical processes during the development of ischemic injury is still not fully understood. In the present work, we record for the first time the real-time dynamics of H2O2 in the matrix of neuronal mitochondria ...
Source: Free Radical Biology and Medicine - August 5, 2023 Category: Biology Authors: Daria A Kotova Alexandra D Ivanova Matvei S Pochechuev Ilya V Kelmanson Yulia V Khramova Alisa Tiaglik Mark A Sudoplatov Arina P Trifonova Anna Fedotova Kseniia Morozova Veronika A Katrukha Anastasia D Sergeeva Roman I Raevskii Mariia P Pestriakova Maxim Source Type: research
