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Total 656 results found since Jan 2013.

Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke
ConclusionsEstradiol levels correlated with functional outcomes (change in mRS) in both men and women, at least in the acute phase (24  h) of stroke. However, no significant difference in estradiol levels is seen 24 h post-stroke in men or women. Testosterone levels decrease at 24 h after stroke in men. As seen in animal models, aromatase levels increase after acute ischemic stroke, but this was only true for women. These ind icate an active aromatization process in post-menopausal women after acute ischemic stroke.
Source: Biology of Sex Differences - January 7, 2021 Category: Biology Source Type: research

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study
ConclusionsThese findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden.
Source: Biology of Sex Differences - November 23, 2016 Category: Biology Source Type: research

Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study
ConclusionOur study indicated a significant,non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274.
Source: Biology of Sex Differences - May 29, 2021 Category: Biology Source Type: research

Sex differences in long-term outcomes among acute ischemic stroke patients with diabetes in China
Conclusions These findings suggest that it is crucial to establish the individual scheme of therapy for every patient by different risk factors of stroke, strengthen the rehabilitation of stroke, and carry on the health education early for the secondary prevention of stroke in patients with diabetes mellitus (DM).
Source: Biology of Sex Differences - December 4, 2015 Category: Biology Source Type: research

Circadian preference and stroke characteristics: A descriptive study
This study set out to explore this relationship by examining whether there was an association between circadian preference and stroke characteristics in a sample of stroke outpatients, considering the time of stroke onset, the topography of the stroke and the resulting disability. We also examined whether sleep complaints (snoring, insomnia, sleep apnea) were associated with circadian preferences (i.e., morning-, evening-, and intermediate-types). We also compared circadian preferences and comorbidities in this sample, matched by age and sex, with those of healthy controls who took part in an epidemiological study (EPISONO...
Source: Chronobiology International - January 5, 2022 Category: Biology Authors: Eveli Truksinas Cristina Frange Giuliano da Paz Eliana Lottenberg Vago Monica Levy Andersen Sergio Tufik Fernando Morgadinho Santos Coelho Source Type: research

Seasonal variation of admission severity and outcomes in ischemic stroke - a consecutive hospital-based stroke registry.
In conclusion, onset seasons were associated with severity and outcomes in ischemic stroke, and patients admitted in spring and winter had more severity and worse outcomes than patients in summer. PMID: 29372813 [PubMed - as supplied by publisher]
Source: Chronobiology International - January 26, 2018 Category: Biology Authors: Liu Y, Gong P, Wang M, Zhou J Tags: Chronobiol Int Source Type: research

Circadian rhythms may not influence the outcomes of thrombolysis in patients with ischemic stroke: A study from China.
In conclusion, there was no evidence to predict that circadian rhythms could influence the outcomes of AIS patients treated with rt-PA in China, although stroke onset during nighttime might aggravate neurological impairment before treatment. Further, multicenter and prospective clinical trials with larger number of subjects are still needed to draw more reliable conclusions. PMID: 29993298 [PubMed - as supplied by publisher]
Source: Chronobiology International - July 11, 2018 Category: Biology Authors: Ding J, Bai Z, Zhou D, Li X, Rajah GB, Ding Y, Han J, Ji X, Meng R Tags: Chronobiol Int Source Type: research

Sex differences in the effects of the moon on ischemic stroke incidence: new findings from Beijing, China.
Abstract Stroke is a major cause of death and disability in China, and no therapies have proven effective to prevent it. Popular belief holds that the lunar cycle affects human physiology, behavior, and health. The aim of our study is to determine whether the lunar cycle impacts the incidence of stroke subtypes [intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and ischemic stroke (IS)]. We retrospectively extracted the discharge registry data of all patients with first-ever acute stroke hospitalized in the affiliated hospital of Beijing University of Traditional Chinese Medicine during 2002-2015. Th...
Source: Chronobiology International - July 12, 2020 Category: Biology Authors: Wang RR, Hao Y, Chen J, Wang MQ, Zheng RY, Shi LS, He J Tags: Chronobiol Int Source Type: research

Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats
ConclusionsThese data show that extensive leakiness of the gut barrier is associated with severe post-stroke disability and suggest that reinforcing this barrier may improve stroke outcomes.
Source: Biology of Sex Differences - January 15, 2021 Category: Biology Source Type: research

Excessive {alpha}-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke Research Communication
The vitamin E family includes both tocopherols and tocotrienols, where α-tocopherol (αTOC) is the most bioavailable form. Clinical trials testing the therapeutic efficacy of high-dose αTOC against stroke have largely failed or reported negative outcomes when a "more is better" approach to supplementation (>400 IU/d) was used. This work addresses mechanisms by which supraphysiologic αTOC may contribute to stroke-induced brain injury. Ischemic stroke injury and the neuroinflammatory response were studied in tocopherol transfer protein-deficient mice maintained on a diet containing αTOC vitami...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Khanna, S., Heigel, M., Weist, J., Gnyawali, S., Teplitsky, S., Roy, S., Sen, C. K., Rink, C. Tags: Research Communication Source Type: research

"MOONSTROKE": Lunar patterns of stroke occurrence combined with circadian and seasonal rhythmicity-A hospital based study.
Abstract Both time of the day and season have been shown to have a significant effect on stroke incidence. In contrast, the role played by the moon has been little studied. We aimed to investigate the potential association of the lunar phase with the incidence of stroke subtypes [intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and ischemic stroke (IS)], adjusted by circadian and seasonal variations. Consecutive stroke admissions to the Royal Melbourne Hospital (RMH) were analyzed from 2004-2011. Of 6252 patients, 4085 (65.3%) had confirmed dates and hour of the day. Of these, 632 (15.5%) had ICH, 6...
Source: Chronobiology International - July 14, 2015 Category: Biology Authors: Mao Y, Schnytzer Y, Busija L, Churilov L, Davis S, Yan B Tags: Chronobiol Int Source Type: research

Serum metabolomic patterns in young patients with ischemic stroke: a case study
ConclusionsSerum metabolomic patterns were significantly different between young patients with ischemic stroke and healthy controls. Our study is beneficial in providing a further view into the pathophysiology of young patients with ischemic stroke.
Source: Metabolomics - February 8, 2021 Category: Biology Source Type: research

Cortical propagation tracks functional recovery after stroke
In conclusion, our new spatiotemporal propagation indicators could represent promising biomarkers that are able to uncover neural correlates not only of motor deficits caused by stroke but also of functional recovery during rehabilitation. In turn, these insights could pave the way tow ards more targeted post-stroke therapies.
Source: PLoS Computational Biology - May 17, 2021 Category: Biology Authors: Gloria Cecchini Source Type: research

Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study
ConclusionHypertension and T2D induced higher risk of overall and ischemic stroke in men than women among Iranian population.
Source: Biology of Sex Differences - March 15, 2022 Category: Biology Source Type: research

Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain Research
Ischemic stroke results in excessive release of glutamate, which contributes to neuronal cell death. Here, we test the hypothesis that otherwise neurotoxic glutamate can be productively metabolized by glutamate oxaloacetate transaminase (GOT) to maintain cellular energetics and protect the brain from ischemic stroke injury. The GOT-dependent metabolism of glutamate was studied in primary neural cells and in stroke-affected C57-BL6 mice using magnetic resonance spectroscopy and GC-MS. Extracellular Glu sustained cell viability under hypoglycemic conditions and increased GOT-mediated metabolism in vitro. Correction of stroke...
Source: FASEB Journal - March 30, 2017 Category: Biology Authors: Rink, C., Gnyawali, S., Stewart, R., Teplitsky, S., Harris, H., Roy, S., Sen, C. K., Khanna, S. Tags: Research Source Type: research