Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment
CONCLUSIONS: Our data demonstrate resolution of inflammation is impaired by DM in AIS patients, implicating a novel mechanism of un-resolved inflammation in DM-related AIS. Furthermore, RvD2 promotes inflammation resolution in macrophages/microglia and protects DM-related AIS, and may thus serve as a novel therapeutic target.PMID:35750271 | DOI:10.1016/j.freeradbiomed.2022.06.231
Source: Free Radical Biology and Medicine - Category: Biology Authors: Xin Tang Lan Liu Zhijuan Miao Jiawei Zhang Xiaolong Cai Bing-Qiao Zhao Gefei Chen Marianne Schultzberg Yuwu Zhao Xiuzhe Wang Source Type: research
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