Thrombus Growth Modelling and Stenosis Prediction in the Cerebral Microvasculature
Publication date: Available online 15 June 2019Source: Journal of Theoretical BiologyAuthor(s): Janani Srree Murallidharan, Stephen J. PayneAbstractCerebral microvascular occlusions cause restriction of blood supply to the brain, thus potentially severely impacting cognitive abilities. Thus, accurate prediction of thrombus growth in realistic geometries is important. Thrombi growth in an existing 13-generation cerebral microvasculature network is simulated here to study the haemodynamic effects of single and multiple blockages on the occlusion of the network. Compared to a single vessel, in a network, the occlusion probabi...
Source: Journal of Theoretical Biology - June 15, 2019 Category: Biology Source Type: research

Practically scheduling hormone therapy for prostate cancer using a mathematical model
Publication date: Available online 13 June 2019Source: Journal of Theoretical BiologyAuthor(s): Ayako Nakanishi, Yoshito HirataAbstractHormone therapy is one of the popular therapeutic methods for prostate cancer. Intermittent androgen suppression (IAS) is the method which stops and resumes hormone therapy repeatedly. The efficacy of IAS differs depending on patients; both the cases have been reported where the relapse of cancer happened and did not happen, for the patients who had undergone IAS. For the patients who cannot avoid the relapse of cancer by IAS, we should delay the relapse of cancer as later as possible. Here...
Source: Journal of Theoretical Biology - June 14, 2019 Category: Biology Source Type: research

Stable cycling in quasi-linkage equilibrium: fluctuating dynamics under gene conversion and selection
Publication date: Available online 13 June 2019Source: Journal of Theoretical BiologyAuthor(s): Timothy W. Russell, Matthew J. Russell, Francisco Úbeda, Vincent A.A. JansenAbstractGenetic systems with multiple loci can have complex dynamics. For example, mean fitness need not always increase and stable cycling is possible. Here, we study the dynamics of a genetic system inspired by the molecular biology of recognition-dependent double strand breaks and repair as it happens in recombination hotspots. The model shows slow-fast dynamics in which the system converges to the quasi-linkage equilibrium (QLE) manifold. On t...
Source: Journal of Theoretical Biology - June 14, 2019 Category: Biology Source Type: research

Scaling laws of cell-fate responses to transient stress
Publication date: Available online 14 June 2019Source: Journal of Theoretical BiologyAuthor(s): Darka Labavić, Mohamed Tahar Ladjimi, Quentin Thommen, Benjamin PfeutyAbstractAnalysis and modelling of dose-survival curves of cells and tissues are often used to assess therapeutic efficacy or environmental risks, much less to infer the intracellular regulatory mechanisms of cellular stress response. However, systematic measurements of how cell survival depends on the time profile of stress, such as exposure duration, provide practical means to decipher the homeostatic dynamics of stress-response regulatory networks. In this ...
Source: Journal of Theoretical Biology - June 14, 2019 Category: Biology Source Type: research

Strategies that enforce linear payoff relationships under observation errors in Repeated Prisoner’s Dilemma game
Publication date: Available online 12 June 2019Source: Journal of Theoretical BiologyAuthor(s): Azumi Mamiya, Genki IchinoseAbstractThe theory of repeated games analyzes the long-term relationship of interacting players and mathematically reveals the condition of how cooperation is achieved, which is not achieved in a one-shot game. In the repeated prisoner’s dilemma (RPD) game with no errors, zero-determinant (ZD) strategies allow a player to unilaterally set a linear relationship between the player’s own payoff and the opponent’s payoff regardless of the strategy that the opponent implements. In contras...
Source: Journal of Theoretical Biology - June 13, 2019 Category: Biology Source Type: research

Theory of coevolution of cytoplasmic male-sterility, nuclear restorer and selfing
Publication date: Available online 13 June 2019Source: Journal of Theoretical BiologyAuthor(s): Atsushi Yamauchi, Takahiro Yamagishi, Ross Booton, Arndt Telschow, Gaku KudoABSTRACTGynodioecy is a sexual polymorphism in angiosperms, where hermaphroditic and female individuals coexist. This is sometimes caused by a cytoplasmic genetic element (CGE) that destroys male functions, which is called cytoplasmic male-sterility (CMS). On the other hand, nuclear genes tend to evolve the ability to restore male function. The coevolutionary process of CMS and the restoration has been studied theoretically. Recently, a theoretical study...
Source: Journal of Theoretical Biology - June 13, 2019 Category: Biology Source Type: research

The role of network structure and time delay in a metapopulation Wilson--Cowan model
Publication date: 21 September 2019Source: Journal of Theoretical Biology, Volume 477Author(s): Federica Conti, Robert A. Van GorderAbstractWe study the dynamics of a network Wilson--Cowan model (a system of connected Wilson--Cowan oscillators) for interacting excitatory and inhibitory neuron populations with time delays. Each node in this model corresponds to a population of neurons, including excitatory and inhibitory subpopulations, and hence it can be viewed as a metapopulation model. It is known that information transfer within each cortical area is not instantaneous, and therefore we consider a system of delay differ...
Source: Journal of Theoretical Biology - June 13, 2019 Category: Biology Source Type: research

Analysis of Feedforward Mechanisms of Multiwhisker Receptive Field Generation in a Model of the Rat Barrel Cortex
Publication date: Available online 12 June 2019Source: Journal of Theoretical BiologyAuthor(s): Mainak PatelAbstractThere is substantial anatomical segregation in the organization of the rodent barrel system – each whisker on the mystacial pad sends input to TC cells within a dedicated thalamic barreloid, which in turn innervates a corresponding cortical barrel, and RS cells within a barrel respond primarily to deflections of the corresponding whisker at the beginning of the dedicated transmission line (the principal whisker, PW). However, it is also well-established that barrel cells exhibit multiwhisker receptive f...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Novelty detection improves performance of reinforcement learners in fluctuating, partially observable environments
Publication date: Available online 12 June 2019Source: Journal of Theoretical BiologyAuthor(s): Sarah E. MarzenAbstractEvolved and engineered organisms must adapt to fluctuating environments that are often only partially observed. We show that adaptation to a second environment can be significantly harder after adapting to a first, completely unrelated environment, even when using second-order learning algorithms and a constant learning rate. In effect, there is a lack of fading memory in the organism’s performance. However, organisms can adapt well to the second environment by incorporating a simple novelty detectio...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Metapopulation model for a prey-predator system: Nonlinear migration due to the finite capacities of patches
Publication date: Available online 10 June 2019Source: Journal of Theoretical BiologyAuthor(s): Hiroki Yokoi, Kei-ichi Tainaka, Kazunori SatoAbstractMany species live in spatially separated patches, and individuals can migrate between patches through paths. In real ecosystems, the capacities of patches are finite. If a patch is already occupied by the individuals of some species, then the migration into the patch is impossible. In the present paper, we deal with prey-predator system composed of two patches. Each patch contains a limited number of cells, where the cell is either empty or occupied by an individual of prey or...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Novel Epidemic Models on PSO-based Networks
Publication date: Available online 10 June 2019Source: Journal of Theoretical BiologyAuthor(s): Dongmei Fan, Guo-Ping Jiang, Yu-Rong Song, Yin-Wei Li, Guanrong ChenAbstractThis paper proposes two spatio-temporal epidemic network models based on popularity and similarity optimization (PSO), called r-SI and r-SIS respectively, in which new connections take both popularity and similarity into account. In the spatial dimension, the epidemic process is described by the diffusion equation; in the time dimension, the growth of an epidemic is described by the logistic map. Both models are represented by partial differential equati...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Protein Complex Identification Based on Weighted PPI Network with Multi-Source Information
Publication date: Available online 11 June 2019Source: Journal of Theoretical BiologyAuthor(s): Yang Yu, Zeyu ZhengAbstractProteins form complexes to accomplish biological functions such as transcription of DNA, translation of mRNA and cell growth. Detection of protein complexes from protein-protein interaction (PPI) networks is the first step for the analysis of biological processes and pathways. Here, we propose a new framework by incorporating Gene Ontology (GO), amino acid background frequency (AABF) and data from von Mering (von Mering data) to identify protein complexes. Firstly, based on the semantic similarity...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Mathematical models of transmission dynamics and vaccine strategies in Hong Kong during the 2017–2018 winter influenza season
Publication date: 7 September 2019Source: Journal of Theoretical Biology, Volume 476Author(s): Shing Hei Ho, Daihai He, Raluca EftimieAbstractTwo mathematical models described by simple ordinary differential equations are developed to investigate the Hong Kong influenza epidemic during 2017–2018 winter, based on overall epidemic dynamics and different influenza subtypes. The first model, describing the overall epidemic dynamics, provides the starting data for the second model which different influenza subtypes, and whose dynamics is further investigated. Weekly data from December 2017 to May 2018 are obtained from th...
Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research

Biologically sound formal model of Hsp70 heat induction
In conclusion, we provide a model that is able to capture the essential dynamics of the Hsp70 heat induction whilst being biologically sound in terms of temperature dependencies, description of protein denaturation and imposed calibration constraints. (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - June 8, 2019 Category: Biology Source Type: research

The role of network structure and time delay in a metapopulation Wilson-Cowan model
Publication date: Available online 7 June 2019Source: Journal of Theoretical BiologyAuthor(s): Federica Conti, Robert A. Van GorderAbstractWe study the dynamics of a network Wilson-Cowan model (a system of connected Wilson-Cowan oscillators) for interacting excitatory and inhibitory neuron populations with time delays. Each node in this model corresponds to a population of neurons, including excitatory and inhibitory subpopulations, and hence it can be viewed as a metapopulation model. It is known that information transfer within each cortical area is not instantaneous, and therefore we consider a system of delay different...
Source: Journal of Theoretical Biology - June 8, 2019 Category: Biology Source Type: research

Pollination-mutualisms in a two-patch system with dispersal
Publication date: Available online 5 June 2019Source: Journal of Theoretical BiologyAuthor(s): Yuanshi WangAbstractIn this paper, we consider a two-patch pollination-mutualism model with dispersal, which is derived from resource-service exchange between the plant and pollinator. The pollinator is assumed to persist in one patch in the presence of pollination-mutualisms, while it can (or cannot) survive alone in the other. Rigorous study on the model exhibits that solutions of the equations are nonnegative and bounded, and there exist stable positive equilibria under conditions. Theoretical analysis on the equilibria demons...
Source: Journal of Theoretical Biology - June 6, 2019 Category: Biology Source Type: research

Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model
Publication date: Available online 5 June 2019Source: Journal of Theoretical BiologyAuthor(s): G. Capo Rangel, J. Prezioso, L. Gerardo-Giorda, E. Somersalo, D. CalvettiAbstractThe energetic needs of brain cells at rest and during elevated neuronal activation has been the topic of many investigations where mathematical models have played a significant role providing a context for the interpretation of experimental findings. A recently proposed mathematical model, comprising a double feedback between cellular metabolism and electrophysiology, sheds light on the interconnections between the electrophysiological details associ...
Source: Journal of Theoretical Biology - June 6, 2019 Category: Biology Source Type: research

Is the cell really a machine?
Publication date: Available online 4 June 2019Source: Journal of Theoretical BiologyAuthor(s): Daniel J. NicholsonAbstractIt has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity. This familiar understanding grounds the conviction that a cell's organization can be explained reductionistically, as well as the idea that its molecular pathways can be construed as deterministic circuits. The machine conception of the cell owes a great deal of its success to the methods traditionally used in molecular biology. However, t...
Source: Journal of Theoretical Biology - June 6, 2019 Category: Biology Source Type: research

L-Ascorbic Acid and the Evolution of Multicellular Eukaryotes
Publication date: Available online 3 June 2019Source: Journal of Theoretical BiologyAuthor(s): John Alexander EdgarAbstractThe lifeless earth was formed around 4.5 billion years ago and the first anaerobic unicellular “organisms” may have appeared half a billion years later. Despite subsequent prokaryotes (bacteria and archaea) evolving quite complex biochemistry and some eukaryote characteristics, the transition from unicellular prokaryotes to multicellular, aerobic eukaryotes took a further 2.5 billion years to begin. The key factor or factors that eventually caused this long-delayed transition is a question ...
Source: Journal of Theoretical Biology - June 5, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: 21 August 2019Source: Journal of Theoretical Biology, Volume 475Author(s): (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - June 5, 2019 Category: Biology Source Type: research

Dynamic and game theory of infectious disease stigmas
Publication date: Available online 30 May 2019Source: Journal of Theoretical BiologyAuthor(s): Timothy C. Reluga, Rachel A. Smith, David P. HughesAbstractStigmas are a primal phenomena, ubiquitous in human societies past and present. Some evolutionary anthropologists have argued that stigmatization in response to disease is an adaptive behavior because stigmatization may help people and communities reduce the risks they face from infectious diseases and increase reproductive success. On the other hand, some cultural anthropologists and social critics argue that stigmatization has strong negative impacts on community health...
Source: Journal of Theoretical Biology - May 31, 2019 Category: Biology Source Type: research

Approximate nutrient flux and concentration solutions of the Nye–Tinker–Barber model by the perturbation expansion method
Publication date: 7 September 2019Source: Journal of Theoretical Biology, Volume 476Author(s): Zhonghui OuAbstractThe Nye–Tinker–Barber model is a basic and representative one for single-ion nutrient uptake by plant root from the soil and we aim to derive its approximate analytical solutions of flux and concentration. We divide the rhizosphere into the inner and the outer fields, match the inner and the outer solutions near the root surface, and then obtain the approximate analytical solutions of nutrient uptake flux at the root surface and global nutrient concentration of the diffusion or the convection-diffus...
Source: Journal of Theoretical Biology - May 30, 2019 Category: Biology Source Type: research

The public goods game with shared punishment cost in well-mixed and structured populations
Publication date: Available online 28 May 2019Source: Journal of Theoretical BiologyAuthor(s): Xianjia Wang, Shaojie LvAbstractBoth experimental and theoretical studies have shown that punishment plays an important role in promoting cooperation. Various forms of punishment are proposed to explain why costly punishment could be maintained in the population and stabilize cooperation. Here we consider an altruistic behavior that cooperators perform cooperation and punishment simultaneously and share the punishment cost. We investigate the role of punishment cost shared among cooperators in the evolution of cooperation in publ...
Source: Journal of Theoretical Biology - May 30, 2019 Category: Biology Source Type: research

Modelling thermodynamic feedback on the metabolism of hydrogenotrophic methanogens
Publication date: Available online 28 May 2019Source: Journal of Theoretical BiologyAuthor(s): T.A. Lynch, Y. Wang, B. van Brunt, D. Pacheco, P.H. JanssenAbstractThe magnitude of the Gibbs free energy change of the substrate transformation that supports the growth of a microbe is decreased when the concentrations of the substrates are decreased and when the concentrations of the products of metabolism are increased. Microbes require a supply of ATP for cell maintenance and growth, and coupling the transformation of substrates to products with the formation of ATP also decreases the magnitude of the Gibbs free energy change...
Source: Journal of Theoretical Biology - May 30, 2019 Category: Biology Source Type: research

The impact of behavioral interventions on co-infection dynamics: an exploration of the effects of home isolation
In conclusion, when providing advise if people should stay at home in the context of two or more co-circulating diseases, one has to take into account epidemiological parameters and symptom severity. (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - May 28, 2019 Category: Biology Source Type: research

Diversity loss is predicted to increase extinction risk of specialist animals by constraining their ability to expand niche
Publication date: Available online 24 May 2019Source: Journal of Theoretical BiologyAuthor(s): Daniel T. Reed, Colin R. ToshAbstractSpecialist animals are at a greater risk of extinction in the face of environmental change than generalist ones. The inability of some specialist taxa to expand host range through evolution may exacerbate or cause their high extinction risk. Here we use connectionism (a framework for modelling animal behaviour) to predict the environmental and physiological factors that predispose some specialist taxa to an ‘evolutionary dead-end’. Neural networks are evolved to become resource-spe...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

Organization in complex brain networks: energy distributions and phase shift
Publication date: Available online 24 May 2019Source: Journal of Theoretical BiologyAuthor(s): Saurabh Kumar Sharma, Soibam Shyamchand Singh, Dineshchandra Haobijam, Md. Zubbair Malik, R.K. Brojen SinghAbstractThe Hamiltonian function of a network, derived from the intrinsic distributions of nodes and edges, magnified by resolution parameter has information on the distribution of energy in the network. In brain networks, the Hamiltonian function follows hierarchical features reflecting a power-law behavior which can be a signature of self-organization. Further, the transition of three distinct phases driven by resolution p...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

Approximate nutrient flux and concentration solutions of the Nye-Tinker-Barber model by the perturbation expansion method
Publication date: Available online 22 May 2019Source: Journal of Theoretical BiologyAuthor(s): Zhonghui OuAbstractThe Nye-Tinker-Barber model is a basic and representative one for single-ion nutrient uptake by plant root from the soil and we aim to derive its approximate analytical solutions of flux and concentration. We divide the rhizosphere into the inner and the outer fields, match the inner and the outer solutions near the root surface, and then obtain the approximate analytical solutions of nutrient uptake flux at the root surface and global nutrient concentration of the diffusion or the convection-diffusion Nye-Tink...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

A stochastic model of adult neurogenesis coupling cell cycle progression and differentiation
Publication date: Available online 22 May 2019Source: Journal of Theoretical BiologyAuthor(s): Anna Stopka, Marcelo BoaretoAbstractLong-term tissue homeostasis requires a precise balance between stem cell self-renewal and the generation of differentiated progeny. Recently, it has been shown that in the adult murine brain, neural stem cells (NSCs) divide mostly symmetrically. This finding suggests that the required balance for tissue homeostasis is accomplished at the population level. However, it remains unclear how this balance is enabled. Furthermore, there is experimental evidence that proneural differentiation factors ...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

Mathematical models of transmission dynamics and vaccine strategies in Hong Kong during the 2017 - 2018 winter influenza season
Publication date: Available online 23 May 2019Source: Journal of Theoretical BiologyAuthor(s): Shing Hei Ho, Daihai He, Raluca EftimieAbstractTwo mathematical models described by simple ordinary differential equations are developed to investigate the Hong Kong influenza epidemic during 2017 - 2018 winter, based on overall epidemic dynamics and different influenza subtypes. The first model, describing the overall epidemic dynamics, provides the starting data for the second model which different influenza subtypes, and whose dynamics is further investigated. Weekly data from December 2017 to May 2018 are obtained from the da...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

A Coupled Multiscale Model to Guide Malaria Control and Elimination
Publication date: Available online 23 May 2019Source: Journal of Theoretical BiologyAuthor(s): Winston Garira, Dephney MathebulaAbstractIn this paper, we share with the biomathematics community a new coupled multiscale model which has the potential to inform policy and guide malaria control and elimination. The formulation of this multiscale model is based on integrating four submodels which are: (i) a sub-model for the mosquito-to-human transmission of malaria parasite, (ii) a sub-model for the human-to-mosquito transmission of malaria parasite, (iii) a within-mosquito malaria parasite population dynamics sub-model and (i...
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: 7 August 2019Source: Journal of Theoretical Biology, Volume 474Author(s): (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - May 24, 2019 Category: Biology Source Type: research

Cell cycle regulation of oscillations yields coupling of growth and form in a computational model of the presomitic mesoderm
Publication date: Available online 20 May 2019Source: Journal of Theoretical BiologyAuthor(s): Murray P.J., Carrieri F. A., Dale J. K.AbstractA striking example of coupling between growth and form occurs during the segmentation of the vertebrate embryo. During segmentation, pairs of segments, one on either side of the anterior-posterior axis, bud off from the presomitic mesoderm (PSM) at regular intervals in time. In the clock and wavefront model, a multicellular oscillator regulates the time at which the next pair of segments form whilst a wavefront regulates their spatial location. In most mathematical models of segmenta...
Source: Journal of Theoretical Biology - May 21, 2019 Category: Biology Source Type: research

Measures of the Efficiency of Natural Selection During Gene Substitution
Publication date: Available online 15 May 2019Source: Journal of Theoretical BiologyAuthor(s): H. Allen OrrAbstractNatural selection is not perfectly efficient: it does not cause the instantaneous substitution of a beneficial mutation. Instead, substitution takes time, reflecting the statistical consequences of fitness differences over some number of generations. In this note, I suggest two measures of the efficiency of natural selection during gene substitution. I compare these measures against both ideal (instantaneous) and failed evolution. I also compare these measures to Haldane's cost of natural selection. (Source: J...
Source: Journal of Theoretical Biology - May 16, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: 21 July 2019Source: Journal of Theoretical Biology, Volume 473Author(s): (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - May 16, 2019 Category: Biology Source Type: research

Mathematical Modelling of a Liver Hollow Fibre Bioreactor
Publication date: Available online 14 May 2019Source: Journal of Theoretical BiologyAuthor(s): Ian Sorrell, Rebecca J Shipley, Sophie Regan, Iain Gardner, Michael P. Storm, Marianne Ellis, John Ward, Dominic Williams, Pratibha Mistry, José Domingo Salazar, Andrew Scott, Steven WebbAbstractA mathematical model has been developed to assist with the development of a hollow fibre bioreactor (HFB) for hepatotoxicity testing of xenobiotics; specifically, to inform the HFB operating set-up, interpret data from HFB outputs and aid in optimizing HFB design to mimic certain hepatic physiological conditions. Additionally, the ...
Source: Journal of Theoretical Biology - May 15, 2019 Category: Biology Source Type: research

Integrated multiscale mathematical modeling of insulin secretion reveals the role of islet network integrity for proper oscillatory glucose-dose response
Publication date: Available online 9 May 2019Source: Journal of Theoretical BiologyAuthor(s): I. Johanna Stamper, Xujing WangAbstractThe integrated multiscale mathematical model we present in this paper is built on two of our previous ones: a model of electrical oscillation in β-cells connected to neighboring cells within a three-dimensional (3D) network, and a model of glucose-induced β-cell intracellular insulin granule trafficking and insulin secretion. In order to couple these two models, we assume that the rate at which primed and release-ready insulin granules fuse at the cell membrane increases with the in...
Source: Journal of Theoretical Biology - May 10, 2019 Category: Biology Source Type: research

Modelling bistable tumour population dynamics to design effective treatment strategies
In this study, we propose a modelling framework to simulate population dynamics of heterogeneous tumour cells with reversible drug resistance. Drug sensitivity of a tumour cell is determined by its internal states, which are demarcated by coordinated activities of multiple interconnected oncogenic pathways. Transitions between cellular states depend on the effects of targeted drugs and regulatory relations between the pathways. Under this framework, we build a simple model to capture drug resistance characteristics of BRAF-mutant melanoma, where two cell states are determined by two mutually inhibitory – main and alt...
Source: Journal of Theoretical Biology - May 10, 2019 Category: Biology Source Type: research

Prologue to the special issue of JTB dedicated to the memory of René Thomas (1928–2017): A journey through biological circuits, logical puzzles and complex dynamics
Publication date: 7 August 2019Source: Journal of Theoretical Biology, Volume 474Author(s): Denis Thieffry, Marcelle Kaufman (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - May 10, 2019 Category: Biology Source Type: research

Neural dynamics in co-morbid schizophrenia and OCD: A computational approach
Publication date: Available online 6 February 2019Source: Journal of Theoretical BiologyAuthor(s): Krisztina Szalisznyó, David N. Silverstein, János TóthAbstractThe co-morbidity of obsessive-compulsive disorder (OCD) and schizophrenia is higher than what would be expected by chance and the common underlying neuropathophysiology is not well understood. Repetitive stereotypes and routines can be caused by perseverative thoughts and motor sequences in both of these disorders. We extended a previously published computational model to investigate cortico-striatal network dynamics. Given the considerable ove...
Source: Journal of Theoretical Biology - May 9, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: 7 July 2019Source: Journal of Theoretical Biology, Volume 472Author(s): (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - May 7, 2019 Category: Biology Source Type: research

Oscillations in well-mixed, deterministic feedback systems: beyond ring oscillators
Publication date: Available online 3 May 2019Source: Journal of Theoretical BiologyAuthor(s): Karen M. PageAbstractA ring oscillator is a system in which one species regulates the next, which regulates the next and so on until the last species regulates the first. In addition, the number of the regulations which are negative, and so result in a reduction in the regulated species, is odd, making the overall feedback in the loop negative. In ring oscillators, the probability of oscillations is maximised if the degradation rates of the species are equal. When there is more than one loop in the regulatory network, the dynamics...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

Warfare Induces Post-Marital Residence Change
Publication date: Available online 3 May 2019Source: Journal of Theoretical BiologyAuthor(s): JiříC. Moravec, Stephen Marsland, Murray P. CoxAbstractPost-marital residence is a sex-biased dispersal defined by the place where a newly-wed couple lives after marriage. Common choices for this practice include patrilocal residence, where the couple lives with the man’s family, and matrilocal residence, where they live with the woman’s family. Deviations from accepted practice typically invoke strong sanctions, but despite this pressure to conform to post-marital residence norms, residence states are unexpect...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

A population dynamics model of cell-cell adhesion incorporating population pressure and density saturation
Publication date: Available online 3 May 2019Source: Journal of Theoretical BiologyAuthor(s): Jose A. Carrillo, Hideki Murakawa, Makoto Sato, Hideru Togashi, Olena TrushAbstractWe discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type populations. The model is based on basic principles of localized repulsion and nonlocal attraction due to adhesion forces at the microscopic level. The new model is able to capture both qualitatively and quantitatively ex...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

Are we prepared for the next influenza pandemic? Lessons from modelling different preparedness policies against four pandemic scenarios
Publication date: Available online 4 May 2019Source: Journal of Theoretical BiologyAuthor(s): Jasmina Panovska-Griffiths, Luca Grieco, Edwin van Leeuwen, Marc Baguelin, Richard Pebody, Martin UtleyAbstractIn the event of a novel influenza strain that is markedly different to the current strains circulating in humans, the population have little/no immunity and infection spreads quickly causing a global pandemic. Over the past century, there have been four major influenza pandemics: the 1918 pandemic (“Spanish Flu”), the 1957-58 pandemic (the “Asian Flu”), the 1967-68 pandemic (the “Hong Kong Fl...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

A Prerequisite for Life
Publication date: Available online 3 May 2019Source: Journal of Theoretical BiologyAuthor(s): Søren ToxvaerdAbstractThe complex physicochemical structures and chemical reactions in living organism have some common features: (1) The life processes take place in the cytosol in the cells, which, from a physicochemical point of view is an emulsion of biomolecules in a dilute aqueous suspension. (2) All living systems are homochiral with respect to the units of amino acids and carbohydrates, but (some) proteins are chiral unstable in the cytosol. (3) And living organism are mortal. These three common features together gi...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

Population abundance of a two-patch chemostat system with asymmetric diffusion
Publication date: Available online 2 May 2019Source: Journal of Theoretical BiologyAuthor(s): Chengguan Tan, Yuanshi Wang, Hong WuAbstractThis paper considers a two-patch chemostat system with asymmetric diffusion, which characterizes laboratory experiments and includes exploitable nutrients. Using dynamical system theory, we demonstrate global stability of the one-patch model, and show uniform persistence of the two-patch system, which leads to existence of a stable positive equilibrium. Analysis on the equilibrium demonstrates mechanisms by which varying the asymmetric diffusion can make the total population abundance in...
Source: Journal of Theoretical Biology - May 2, 2019 Category: Biology Source Type: research

Predicting protein sub-Golgi locations by combining functional domain enrichment scores with pseudo-amino acid compositions
Publication date: Available online 30 April 2019Source: Journal of Theoretical BiologyAuthor(s): Wei Zhao, Guang-Ping Li, Jun Wang, Yuan-Ke Zhou, Yang Gao, Pu-Feng DuAbstractGolgi apparatus is an important subcellular organelle that participates the secretion pathway. The role of Golgi apparatus in cellular process is related with Golgi-resident proteins. Knowing the sub-Golgi locations of Golgi-resident proteins is helpful in understanding their molecular functions. In this work, we proposed a computational method to predict the sub-Golgi locations for the Golgi-resident proteins. We take three sub-Golgi locations into co...
Source: Journal of Theoretical Biology - May 1, 2019 Category: Biology Source Type: research

The paradox of tolerance: parasite extinction due to the evolution of host defence
Publication date: Available online 30 April 2019Source: Journal of Theoretical BiologyAuthor(s): Caterina Vitale, Alex BestAbstractHost defence against parasite infection can rely on two broad strategies: resistance and tolerance. The spread of resistance traits usually lowers parasite prevalence and decreases selection for higher defence. Conversely, tolerance mechanisms increase parasite prevalence and foster selection for more tolerance. Here we examine the potential for the host to drive parasites to extinction through the evolution of one or other defence mechanism. We analysed theoretical models of resistance and tol...
Source: Journal of Theoretical Biology - May 1, 2019 Category: Biology Source Type: research

Modeling the effect of tat inhibitors on HIV latency
Publication date: 21 July 2019Source: Journal of Theoretical Biology, Volume 473Author(s): Luis U. Aguilera, Jesús Rodríguez-GonzálezAbstractEven in the presence of a successful combination therapy stalling the progress of AIDS, developing a cure for this disease is still an open question. One of the major steps towards a cure would be to be able to eradicate latent HIV reservoirs present in patients. During the last decade, multiple findings point to the dominant role of the viral protein Tat in the establishment of latency. Here we present a mathematical study to understand the potential role of Tat ...
Source: Journal of Theoretical Biology - April 29, 2019 Category: Biology Source Type: research