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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Detection of symptomatic carotid atherosclerosis from 18F-fluorodeoxyglucose and 18F-sodium fluoride positron emission tomography after stroke: A prospective study
Aim: We investigated whether symptomatic carotid atherosclerosis can be detected by using 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) positron emission tomography (PET) among cerebral infarction patients.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok Source Type: research
Evaluation of intracranial circulation by transcranial ultrasound: Useful method for selection of patients with asymptomatic carotid stenosis to carotid endarterectomy. Single center experience
Aim: Of all ischemic strokes 15-20% result from carotid occlusive disease.Of these up to 80% occur without previous transient ischemic attack The prevalence of asymptomatic carotid artery stenosis (CAS) in general population is 2-8%.Annual risk of ipsilateral stroke is currently estimated to be 1-2% meaning that routin CAE is not justified.However there are patients with substantial higher risk whom CAE is still indicated in.Hence risk stratification is needed.One of the options is to test intracranial haemodynamic by Transcranial Color-coded Sonography (TCCS) at rest and cerebrovascular reserve (CVR).There is evidence tha...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jiri Zizka Source Type: research
Symptomatic carotid atherosclerosis detection by positron emission tomography imaging
Aim: We investigated whether sodium fluoride (NaF) positron emission tomography (PET) were superior to fluorodeoxyglucose (FDG) PET in the detection of symptomatic carotid artery among stroke patients with carotid artery stenosis.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok, Oh -Sang Kwon Source Type: research
The prevalence and distribution of intracranial carotid artery calcification in the young and middle-aged
We examined the prevalence and volume of ICAC in a large sample of young and middle aged individuals.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Daniel Bos, Remko Kockelkoren, Willem Aussems, Meike Vernooij, Willem Mali, Pim de Jong, Aad van der Lugt Source Type: research
A hemorrhagic transformation model of mechanical stroke therapy with acute hyperglycemia in mice
Aim: Clinical benefit for mechanical thrombectomy (MT) in stroke was recently demonstrated in multiple large prospective studies. The aim of this therapy is to achieve a complete reperfusion in a short delay, given that reperfusion damage is dependent on the time of ischemia. Acute hyperglycemia is an important risk factor of poor outcome in stroke patients, including those that underwent MT. Here, we investigated the effect of acute hyperglycemia in a mouse model of ischemic stroke subjected to different times (30, 90 and 180 min) of middle cerebral artery occlusion (MCAO).
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: David Couret, Aur élie Catan, Brice Nativel, Cynthia Planesse, Anne-Claire Dorsemans, Imade Ait-Arsa, Maxime Cournot, Alexy Tran-Dinh, Gilles Lambert, Nicolas Diotel, Olivier Meilhac Source Type: research
High circulating levels of LOX-1 are associated with elevated risk of ischemic stroke
Aim: Lectin-like oxidized LDL receptor-1 (LOX-1) is up-regulated in atherogenic conditions. Whether LOX-1 is associated with increased risk for ischemic stroke is largely unknown. We aimed to investigate the relation between circulating levels of LOX-1, carotid plaque and incidence of ischemic stroke.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hanna Markstad, Eva Bengtsson, Harry Bj örkbacka, Gunilla Nordin Fredrikson, Andreas Edsfeldt, Olle Melander, Marju Orho-Melander, Jan Nilsson, Isabel Gonçalves, Gunnar Engström Source Type: research
Relationship of platelet thromboxane inhibition by aspirin and all-cause mortality in patients with stable coronary artery disease
Aim: Anti-platelet therapy with aspirin (ASA) reduces nonfatal myocardial infarction, stroke, and cardiovascular death by irreversibly inhibiting platelet COX-1 and TxA2 production. However, variable TxA2 inhibition is common. We studied the relationship of urinary 11dhTxB2, an inactive TxA2 metabolite, with all-cause mortality in stable coronary artery disease (CAD) patients on ASA treatment.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Luis R. Lopez, Anupama Vasudevan, Mohanakrishnan Sathyamoorthy, Jeffrey M. Schussler, Carlos Velasco, Caren Swift, Raphael Schiffmann, Teodoro Boittiglieri, Peter A. McCullough Source Type: research
Activation of protease-activated receptors in patients with new onset of atrial fibrillation contributes to systemic atherosclerotic risk
Aim: Atrial fibrillation (AF) remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world. A complex array of pathophysiological changes including fibrosis and inflammation increasing the propensity of the atria to develop or maintain AF. At the same time, these alterations are involved in the occurrence of the systemic hypercoagulable state in which protease-activated receptors (PARs) 1 and 2 are discussed to be mediators. We wanted to evaluate the pathomechanistic link between inflammation, hypercoagulability and the atherosclerotic risk in the context of PAR1 and PAR2 activation.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Julian Friebel, Marco Witkowski, Termeh Tabaraie, Max Wegner, Evelyn R üdiger, Daniel Steffens, Oskar Galuszka, Mario Kasner, Ulf Landmesser, Ursula Rauch-Kröhnert Source Type: research
Intraindividual variability of lipoprotein(a) and implications for the decision-making process for lipoprotein(a) lowering therapy
Aim: Lipoprotein (a) is an independent risk factor for myocardial infarction, stroke and calcific aortic valve stenosis. Circulating Lp(a) levels are largely genetically determined by SNP and a wide heterogeneity in kringle IV type 2 repeats. Furthermore, significant racial differences exist. Lifestyle modifications like nutrition and sports have no or less effect on Lp(a) serum levels.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Michael Marcus Hoffmann, Lisa Sch äfer, Karl Winkler, Brigitte König Source Type: research
Vulnerable atherosclerotic plaque model in atherosclerotic swine and a potential target site for intervention
Aim: Unstable/vulnerable plaques are characterized by a thin cap fibroatheroma and necrotic core, and may result in serious clinical conditions, including transient ischemic attack, stroke, aphasia, and other motor defects. The precise mechanism of plaque rupture remains to be defined to identify target site(s) for intervention. Here, we report a novel swine model of vulnerable plaque and identified a potential target site for intervention.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Devendra K. Agrawal, Mohamed M. Radwan, Zefu Zhang, Antu Antony Source Type: research
Dietary intake of alpha-linolenic acid and the risk of ischemic stroke subtypes
Aim: Intake of alpha-linolenic acid (ALA) may reduce the risk of atherosclerotic cardiovascular disease. We aimed to investigate the association between dietary intake of ALA and the risk of ischemic stroke subtypes.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Christian Bork, Stine Krogh Ven ø, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Kim Overvad, Erik Berg Schmidt Source Type: research
Substitution of monounsaturated fatty acid for linoleic acid and the risk of ischemic stroke
Aim: The influence of dietary factors on stroke risk is limited. But the major n-6 polyunsaturated fatty acid linoleic acid (LA) has been proposed beneficial in prevention of ischemic stroke.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Stine Krogh Ven ø, Kim Overvad, Marianne Uhre Jakobsen, Søren Lundbye-Christensen, Flemming Winther Bach, Erik Berg Schmidt Source Type: research
Comparison of ct and MRI on the detection and quantification of carotid artery calcification: The rotterdam study
Aim: Carotid artery atherosclerosis is an important risk factor for stroke. As such, quantification of carotid artery calcification, as a proxy of atherosclerosis, has become an important topic in stroke-research. Yet, population based studies are lacking in comparing these imaging modalities on the ability to detect and quantify calcification and which modality is most effective.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Blerim Mujaj, Andres M. Arias Lorza, Arna Van Engelen, Marleen De Bruijne, Oscar H. Franco, Aad Van Der Lugt, Meike W. Vernooij, Daniel Bos Source Type: research
PET-CT imaging of atherosclerosis in Ldlr-/- mice treated with an anti-LDL(-) nanoformulation
Aim: Atherosclerosis is a chronic inflammatory disease underlying the myocardial infarction and ischemic stroke. The electronegative low-density lipoprotein (LDL-), an in vivo modified subfraction of LDL, is pro-inflammatory and plays a key role in atherosclerosis contributing to foam cells formation. In the nanotechnology field, some strategies have emerged such as the use of nano-carriers with synthetic polymer nanoparticles and nanoparticle-protein conjugates as promising approaches for the prevention and treatment of diseases.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Dulcineia Abdalla, Marcela Cavalcante, Walter Turato, Soraya Kazuma, Marcia Adorne, Silvia Guterres, Adriana Pohlmann Source Type: research
Secretory phospholipase A2 modified high-density lipoprotein potently suppresses platelet activation
Aim: Levels of secretory phospholipases A2 (sPLA2) highly increase under acute and chronic inflammatory conditions. sPLA2 is mainly associated with high-density lipoproteins (HDL) and generates bioactive lysophospholipids implicated in acute and chronic inflammatory processes. Unexpectedly, pharmacological inhibition of sPLA2 in patients with acute coronary syndrome was associated with an increased risk of myocardial infarction and stroke. Given that platelets are key players in thrombosis and inflammation, we hypothesized that sPLA2-induced hydrolysis of HDL-associated phospholipids (sPLA2-HDL) generates modified HDL part...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Gunther Marsche, Michael Holzer, Sanja Curcic Source Type: research
