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Source: Atherosclerosis

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Total 436 results found since Jan 2013.

Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack
RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting a possible role of TPO-Ab as a second hit for developing RNF213-related vasculopathy. We investigated the association of TPO-Ab levels with RNF213-related ischemic stroke (IS)/transient ischemic attack (TIA), other than moyamoya disease.
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Takeshi Yoshimoto, Hiroyuki Ishiyama, Yorito Hattori, Kunihiro Nishimura, Yoko Okada, Hideaki Watanabe, Yasumasa Ohyagi, Yasuhisa Akaiwa, Tomoyuki Miyamoto, Michi Kawamoto, Masahiko Ichijo, Hiroyasu Inoue, Noriyuki Matsukawa, Toshiki Mizuno, Hirofumi Mats Source Type: research

Therapeutic targeting of the LncRNA IMSET suppresses inflammation and atherosclerotic plaque progression
Background and Aims: Perpetual monocyte/macrophage recruitment and subsequent foam cell formation characterises advanced atherosclerotic plaques, especially lesions precipitating myocardial infarction and stroke. Recent advances have illuminated macrophage diversity within atherosclerotic plaques, with select populations attributed a deleterious role. Accordingly, novel targets within specific macrophage subsets may yield therapeutic potential.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: K. Di Gregoli, A. Bond, S. Smith, S. George, J. Johnson Source Type: research

Low-density lipoprotein cholesterol levels are associated with subsequent stented-territory ischemic stroke after carotid artery stenting
Background and Aims: Uncontrolled low-density lipoprotein cholesterol (LDL-C) is an important risk factor for carotid stenosis. However, the role of LDL-C after carotid artery stenting (CAS) is not well known with respect to stented-territory infarction (STI) and in-stent restenosis (ISR). We hypothesized that LDL-C levels after CAS might be independently associated with STI and ISR.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S.M. Kim, J.C. Ryu, S. Koo, B.J. Kim Source Type: research

Biliverdin reductase B is a plasma biomarker for intraplaque hemorrhage and a predictor of ischemic stroke in symptomatic carotid stenosis
Background and Aims: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with plaque IPH. We explored the biomarker potential of plasma BLVRB through 1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI) and with recurrent ischemic stroke; and 2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Chemaly, D. Marlevi, M.-J. Iglesias, M. Lengquist, M. Kronqvist, D. Bos, D.H.K. Van Dam-Nolen, A. Van Der Kolk, J. Hendrikse, M. Kassem, L. Matic, J. Odeberg, M.R. De Vries, M.E. Kooi, U. Hedin Source Type: research

Plasma TSH and cardiovascular risk in the general population
Background and Aims: The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Dalila, R. Frikke-Schmidt, B. Nordestgaard, A. Tybjaerg-Hansen Source Type: research

Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research

Elevated remnant cholesterol in atherosclerotic cardiovascular disease in diabetes: A population-based prospective cohort study
Background and Aims: Elevated remnant cholesterol is causally associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of peripheral artery disease, myocardial infarction, ischemic stroke, and any ASCVD in individuals with diabetes.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: B. Wadstr öm, K. Pedersen, A. Wulff, B. Nordestgaard Source Type: research

Type 2 diabetes mellitus, atherosclerosis, and ischemic stroke: Histopathological changes of the brain
Background and Aims: Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including cerebrovascular disease. Atherosclerosis and ischemic stroke in diabetic patients occur 4 times more often than in the general population. Our aim was to investigate the brain tissue of patients with type 2 diabetes mellitus who died from ischemic stroke.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: L. Volos, T. Mykhaylichenko Source Type: research

Small dense LDL cholesterol and ischemic stroke
Background and Aims: For decades it has been suggested that small dense low-density lipoprotein (sdLDL) may be particularly atherogenic. High levels of sdLDL are associated with an increased risk of ischemic heart disease; however, the association of sdLDL with ischemic stroke has not been explored in a large prospective study on the general population. We tested the hypothesis that high sdLDL cholesterol levels are associated with an increased risk of ischemic stroke.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Balling, B. Nordestgaard, A. Varbo, A. Langsted, P. Kamstrup, S. Afzal Source Type: research

The role of atherogenic dyslipidemia, endothelial dysfunction and systemic inflammation in the development of vascular complications in patients with NAFLD
Background and Aims: Patients with NAFLD are at high risk of coronary heart disease and stroke, but the mechanisms are not yet fully understood. Aim is to determine the relationship between atherogenic dyslipidemia, systemic inflammation, endothelial dysfunction as causes of cardiovascular complications in patients with NAFLD.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: K. Pivtorak, I. Fedzhaga, O. Marchuk, N. Pivtorak Source Type: research

Clinical profiles and one-year outcome in middle eastern patients with atrial fibrillation and major bleeding events. The Jordan atrial fibrillation study
Background and Aims: Oral anticoagulant agents (OACs) reduce the risk of stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) but may increase the risk of major bleeding (MB) events. There is a scarcity of studies that address the incidence, predictors, and outcomes of bleeding events in AF patients in the Middle East. This contemporary multicenter study sought to evaluate in detail the bleeding events and predictors of these events
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: A. Hammoudeh, Y. Khader, Y. Badaineh, R. Tabbalat, S. Rawashdeh, M. Jammal, S. Abrumman, I. Alhaddad Source Type: research

LP(a) levels related in severity and disability of ischemic stroke
Background and Aims: Lipoprotein(a) [Lp(a)] concentration is a causal risk factor for atherosclerotic cardiovascular disease.The association of Lp(a) and stroke-related neurologic deficits and stroke functional outcomes is unclear. The aim was to analyze whether high Lp(a) is associated with stroke severity and unfavorable functional outcomes.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: À. Pedragosa, A. Alija, M. Carmona, F. Ríos, C. Guerrero, R. Borrallo, M. Mauri Source Type: research

Loss of function and missense variants in CCR2 and protection against atherosclerotic disease
Background and Aims: MCP-1 governs monocyte recruitment to atherosclerotic lesions. Coherent evidence from genetic analyses and large-scale epidemiological studies supports an association between circulating MCP-1 levels and risk of coronary artery disease and atherosclerotic stroke. Still, it remains unknown if pharmacologically targeting CCR2, the cognate receptor of MCP1, would offer protection against cardiovascular disease.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Georgakis, R. Malik, M. Dichgans Source Type: research

BMP-7 attenuates TLR4-NLRP3 inflammasome mediated pyroptosis in vascular smooth muscle cells in atherosclerotic plaques
Background and Aims: Atherosclerosis (ATH) is an inflammation-mediated disease in which cell death underlies the formation of lesions along the intima layer of vascular walls resulting in vessel narrowing, decreased blood-flow, and increased risk of lesion rupture leading to myocardial infarction and stroke. The current study was undertaken to investigate whether inflammation in ATH can induce pyroptosis in vascular smooth muscle cells (vSMC ’s). To study this, we established disturbed flow-induced hemodynamic injury to the vascular wall using our partial left carotid artery ligation (PLCA) model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: D. Singla, C. Narasimhulu Source Type: research

Ischemic stroke patients with carotid atherosclerosis show dysfunctional high-density lipoprotein particles
Background and Aims: Twenty percent of ischemic strokes are caused by atherosclerosis from the internal carotid artery. HDL plays a protective role against the development of atherosclerosis. We aimed to compare the composition and the function of the HDL from ischemic stroke patients with carotid atherosclerosis and from healthy controls.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Puig, A. Sol é, A. Aguilera-Simón, E. Jiménez-Xarrié, P. Camps-Renom, J.L. Sanchez-Quesada, S. Benitez Source Type: research