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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death
A vulnerable plaque is an atherosclerotic plaque that is rupture-prone with a higher risk to cause cardiovascular symptoms such as myocardial infarction or stroke. Mimecan or osteoglycin is a small leucine-rich proteoglycan, important for collagen fibrillogenesis that has been implicated in atherosclerotic disease, yet the role of mimecan in human atherosclerotic disease remains unknown.
Source: Atherosclerosis - September 24, 2020 Category: Cardiology Authors: Christoffer Tengryd, Signe Holm Nielsen, Michele Cavalera, Eva Bengtsson, Federica Genovese, Morten Karsdal, Pontus Dun ér, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeldt, Isabel Gonçalves Source Type: research
Carotid stent occlusion after emergent stenting in acute ischemic stroke: Incidence, predictors and clinical relevance
Emergent stent placement may be required during neurothrombectomy. Our aim was to investigate the incidence, predictors and clinical relevance of early extracranial carotid stent occlusion following neurothrombectomy.
Source: Atherosclerosis - September 9, 2020 Category: Cardiology Authors: Arturo Ren ú, Jordi Blasco, Carlos Laredo, Laura Llull, Xabier Urra, Victor Obach, Antonio López-Rueda, Salvatore Rudilosso, Federico Zarco, Elisabet González, José David Guio, Sergio Amaro, Angel Chamorro Source Type: research
Predicted impact of increasing average ambient temperature over the coming century on mortality from cardiovascular disease and stroke in the USA
Future climate change may adversely impact human health. The direct effects of extreme hot temperatures on mortality are well established, and their future impact well modelled. However, less extreme changes in ambient temperature (Ta) have been previously associated with increased mortality from circulatory and metabolic diseases, but their future impact is less clear.
Source: Atherosclerosis - September 6, 2020 Category: Cardiology Authors: Mohsen Mazidi, John R. Speakman Source Type: research
Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study
We aimed to investigate the association of serum glycated albumin (GA) levels with the risk of cardiovascular disease (CVD) and its subtypes, including coronary heart disease (CHD) and stroke, in a general Japanese population.
Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Akane Mihara, Tomoyuki Ohara, Jun Hata, Takanori Honda, Sanmei Chen, Satoko Sakata, Emi Oishi, Yoichiro Hirakawa, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya Source Type: research
Lifetime risk predictions for cardiovascular diseases: competing risks analyses on a population-based cohort in Sweden
There are guideline discussions on a lifetime approach to cardiovascular risk. Many of the available risk models estimate the short-term, usually 10-year risk of non-fatal and fatal cardiovascular diseases (CVD) grouped together. We aimed to develop lifetime risk models for non-fatal coronary heart disease, stroke, heart failure and death from CVD and non-CVD.
Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Anna Stenling, Christel H äggström, Margareta Norberg, Fredrik Norström Source Type: research
Influence of lipoprotein-associated phospholipase A2 mass on prognosis value of baseline platelet count for clinical outcomes after acute ischemic stroke
We aimed to examine the association between baseline platelet count (PLT) and prognosis of acute ischemic stroke according to lipoprotein-associated phospholipase A2 (Lp-PLA2) mass.
Source: Atherosclerosis - July 4, 2020 Category: Cardiology Authors: Suwen Shen, Chongke Zhong, Aili Wang, Liyuan Han, Zhengbao Zhu, Yanbo Peng, Hao Peng, Daoxia Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He Source Type: research
Progression of valvular calcification and risk of incident stroke: The Multi-Ethnic Study of Atherosclerosis (MESA)
Prevalent valvular calcification (VC) is associated with stroke but little is known about associations of VC progression with stroke.
Source: Atherosclerosis - July 3, 2020 Category: Cardiology Authors: Oluwaseun E. Fashanu, Anas Bizanti, Ahmad Al-Abdouh, Di Zhao, Matthew J. Budoff, Isac C. Thomas, W.T. Longstreth, Erin D. Michos Source Type: research
Tissue factor in atherosclerosis and atherothrombosis
Atherosclerosis is a chronic inflammatory disease that is characterized by the formation of lipid rich plaques in the wall of medium to large sized arteries. Atherothrombosis represents the terminal manifestation of this pathology in which atherosclerotic plaque rupture or erosion triggers the formation of occlusive thrombi. Occlusion of arteries and resultant tissue ischemia in the heart and brain causes myocardial infarction and stroke, respectively. Tissue factor (TF) is the receptor for the coagulation protease factor VIIa, and formation of the TF:factor VIIa complex triggers blood coagulation.
Source: Atherosclerosis - July 1, 2020 Category: Cardiology Authors: Steven P. Grover, Nigel Mackman Tags: Review article Source Type: research
Platelets as therapeutic Targets to prevent Atherosclerosis
Cardiovascular disease remains the main cause of death worldwide. For this reason, strategies for the primary prevention of atherosclerosis and atherosclerosis-related pathologies like stroke or myocardial infarction are needed.Platelets are key players of atherosclerosis-related vascular thrombotic pathologies and their role as targets in secondary prevention of atherosclerosis-related complications is uncontested. However, platelets also play an important role in the initiation and progression of atherosclerosis.
Source: Atherosclerosis - June 12, 2020 Category: Cardiology Authors: Henry Nording, Lasse Baron, Harald F. Langer Source Type: research
A heritable netrin-1 mutation increases atherogenic immune responses
Atherosclerosis and its major clinical manifestations – myocardial infarction, ischemic stroke and peripheral artery disease – remain a leading cause of death worldwide [1]. The onset of atherosclerosis is driven by the accumulation and expansion of macrophages in the artery wall in response to lipid deposition. Subsequently, the macrophage's failu re to resolve the inflammation and to exit the plaque are key processes in the progression of atherosclerosis [2]. Understanding the underlying causes and pathological mechanisms of this chronic, low grade inflammation that sustains plaque progression has been a major focus ...
Source: Atherosclerosis - April 9, 2020 Category: Cardiology Authors: Martin Schlegel, Kathryn J. Moore Tags: Editorial Source Type: research
Design and validation of prehospital acute stroke triage (PAST) scale to predict large vessel occlusion
Acute ischemic stroke patients with large vessel occlusion (LVO) have severe symptoms and poor prognosis. Early recognition of these patients in prehospital setting contributes to rapid triage to comprehensive stroke centers with endovascular therapy conditions. We aimed to develop a simple and efficient scale to identify LVO and compare with other published scales.
Source: Atherosclerosis - April 3, 2020 Category: Cardiology Authors: Shiyu Li, Anxin Wang, Xiaoli Zhang, Yongjun Wang Source Type: research
Oxidized low-density lipoprotein (LDL) and LDL cholesterol are associated with outcomes of minor stroke and TIA
Low-density lipoprotein (LDL) and oxidized low-density lipoprotein (oxLDL) levels are thought to be related to recurrent stroke. However, the joint association of circulating LDL and oxLDL levels with the outcomes of acute minor ischemic stroke and transient ischemic attack (TIA) remains unclear. The goal of the study was to evaluate whether LDL and oxLDL have a combined effect on outcomes of acute minor stroke and TIA.
Source: Atherosclerosis - February 17, 2020 Category: Cardiology Authors: Anxin Wang, Liye Dai, Nan Zhang, Jinxi Lin, Guojuan Chen, Yingting Zuo, Hao Li, Yilong Wang, Xia Meng, Yongjun Wang Source Type: research
A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility
The insulin-like growth factor (IGF)-1 signalling pathway has been implicated in the pathogenesis of atherosclerosis; however, the mechanism underlying its role in stroke remains unexplained. Herein, we aimed to explore the effects of genetic polymorphisms in the IGF1 pathway on stroke in the Chinese Han population.
Source: Atherosclerosis - January 17, 2020 Category: Cardiology Authors: Yingshui Yao, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Chong Shen Source Type: research
Development of a novel score to predict newly diagnosed atrial fibrillation after ischemic stroke: The CHASE-LESS score
Prompt detection of atrial fibrillation (AF) is essential for optimal secondary stroke prevention, but routine long-term cardiac monitoring of all ischemic stroke patients is neither practical nor affordable. We aimed to develop and validate a risk score to identify patients at risk for newly diagnosed AF (NDAF) after ischemic stroke.
Source: Atherosclerosis - January 12, 2020 Category: Cardiology Authors: Hsieh Cheng-Yang, Lee Cheng-Han, Sung Sheng-Feng Source Type: research
Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study
This study investigated the association of bile acid excretion (BAE) with stroke incidence and mortality.
Source: Atherosclerosis - December 13, 2019 Category: Cardiology Authors: Gideon Charach, Eli Karniel, Ilya Novikov, Leonid Galin, Shely Vons, Itamar Grosskopf, Lior Charach Source Type: research
