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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells
The factor VII activating protease (FSAP) knockout mice have a bigger neointima after vascular injury and a larger infarct volume after stroke. The Marburg I (MI) single nucleotide polymorphism (SNP) in the FSAP-encoding gene is associated with an increased risk of stroke and carotid stenosis in humans. We hypothesize that the regulation of gene expression by FSAP in vascular cells accounts for its vasculo-regulatory properties.
Source: Atherosclerosis - August 25, 2017 Category: Cardiology Authors: Kristina Byskov, Thomas Boettger, Paul F. Ruehle, Nis Valentin Nielsen, Michael Etscheid, Sandip M. Kanse Source Type: research
Increased diabetes risk and interaction with social and medical events in patients upon stroke: Two nationwide studies
This study evaluated diabetes risk and post-diabetes adverse events in patients with stroke.
Source: Atherosclerosis - August 22, 2017 Category: Cardiology Authors: Lu-Min Chu, Chih-Chung Liu, Chun-Chieh Yeh, Yi-Cheng Chang, Chaur-Jong Hu, Chun-Chuan Shih, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao Source Type: research
The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis
Genetic studies have been reported on the association between APOA5, APOB, APOC3 and ABCA1 gene polymorphisms and ischemic stroke, but results remain controversial. Hence, this meta-analysis aimed to infer the causal relationships of APOA5 (rs662799, rs3135506), APOB (rs693, rs1042031, rs1801701), APOC3 (rs4520, rs5128, rs2854116, rs2854117) and ABCA1 rs2230806 with ischemic stroke risk.
Source: Atherosclerosis - August 19, 2017 Category: Cardiology Authors: Anthony Au, Lyn R. Griffiths, Looi Irene, Cheah Wee Kooi, Loo Keat Wei Source Type: research
GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by hyperglycaemia and insulin resistance. Diabetes mellitus is well-established as a major risk factor for the development of cardiovascular disease (CVD). A collaborative meta-analysis of 102 prospective studies revealed that people with diabetes are exposed to two-fold excess risk for coronary heart disease and stroke after adjustment for lipid profiles and inflammatory markers [1]. Moreover, prevention of cardiovascular complications is regularly integrated in the regime of medical care in diabetic patients, as these patients have a similar ri...
Source: Atherosclerosis - August 18, 2017 Category: Cardiology Authors: Ya-Lan Ying, Yung-Chih Chen, Karin Jandeleit-Dahm, Karlheinz Peter Tags: Editorial Source Type: research
Effect of high-dose atorvastatin therapy accompanied by discontinuation of cholesterol-rich diet on color-doppler ultrasonography parameters of atherosclerotic carotid artery
Aim: Atherosclerosis is the underlying reason for nearly all causes of coronary artery disease and peripheral arterial disease and many cases of stroke. Carotid color-Doppler ultrasonography is a popular tool for evaluating atherosclerosis of the carotid artery. The aim of this study was to generate a rabbit model of carotid arterial atherosclerotic stenosis and the subsequent investigating the effect of high-dose atorvastatin therapy on color-Doppler ultrasonography parameters in this model.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hossein Mehrad, Manijhe Mokhtari-Dizaji, Hossein Ghanaati Source Type: research
Inertial cavitation effect of catheter- based Q-switched ND:YAG laser enhance extracorporeal pulsed- focused ultrasound thrombolysis
Aim: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Focused ultrasound is one of the non- invasive methods to treat abnormal tissues. In pulsed- focused ultrasound with low duty cycle, which is used for thrombolysis, energy deposition rates are low enough that temperature rises are well below the threshold for thermal damage.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hossein Mehrad, Mehdi Farhoudi, Alireza Paknezhad Source Type: research
2.6-fold risk of ischemic stroke in individuals with clinical familial hypercholesterolemia: The copenhagen general population study with 102,961 individuals
Aim: Familial hypercholesterolemia(FH) is a condition with high concentrations of low-density lipoprotein cholesterol, and high risk of ischemic heart disease. However, there is contradictory information on whether these individuals have higher risk of ischemic stroke.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Sabina Beheshti, Christian Medom Madsen, Anette Varbo, B ørge Grønne Nordestgaard Source Type: research
Strong associations between current periodontal condition and stroke, but not past major cardiovascular events
Aim: To evaluate the association between current periodontal condition and past cardiovascular and stroke events in a cohort of patients treated for chronic coronary artery disease from a university hospital in Brazil.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Leopoldo Pentead Nucci, Irineu Gregnamin Pedron Source Type: research
Impact of the hypertension and carotid intima-media thickness to the infarcts volume in the stroke patients
Aim: Cognitive deficit among hypertensive elderly patients with brain infarcts was established during last years, represents the basis of vascular dementia in late life still, but their link with intima media thickness (IMT) remains controversially as well as the stroke volume
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Nino Lobjanidze, Nino Akiashvili, Ketevan Esartia, Marina Janelidze, Marika Alpaidze Source Type: research
Clinical case of hyperlipidemia type IV in a man with diabetes, myocardial infarction and stroke
Aim: Hypercholesterolemia is one of the main risk factors of atherosclerosis development. Lipid disorders occur as a result of some genetic abnormalities or secondary to underlying disease, for example, diabetes mellitus. Insulin resistance in such patient is often the reason of hypertriglyceridemia and low serum high-density lipoprotein cholesterol concentrations. Hypertriglyceridemia is the most common lipid abnormality in young patients with myocardial infarction.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Olga Baturina, Olga Mironova Source Type: research
Impact of physical activity and sedentary behavior on biological risk factors of carotid atherosclerotic plaque instability
Aim: Carotid atherosclerosis plaque instability is increased by intraplaque hemorrhage (IPH) and neovascularization. Oxidative stress is known to promote these two risk factors and induce a vicious circle with IPH and neovascularization. Moreover, it was shown that regular physical activity can reduce oxidative stress by increasing antioxidant defenses whereas sedentary behavior can increase oxidative stress independently to physical activity. The aim of this study was therefore to evaluate the effects of both physical activity and sedentary behavior on the carotid plaque histological characteristics and oxidative stress i...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Pauline Mury, Antoine Millon, Mathilde Mura, Virginie Nicaise, Vincent Pialoux Source Type: research
Effects of major adipokines on the long-term outcome of patients with acute ischemic stroke
Aim: The effects of adiponectin, leptin and resistin on the long-term outcome of ischemic stroke are controversial. We aimed to evaluate whether serum levels of these adipokines and the -420C>G polymorphism of the resistin gene promoter affect the long-term outcome of ischemic stroke.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Stella Bouziana, Konstantinos Tziomalos, Antonios Goulas, Timoleon Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Hatzitolios Source Type: research
The effect of the presence and the level of dyslipidemia control on diabetic patients with first acute ischemic stroke
Aim: Study of the effect of the presence and the level of dyslipidemia control on patients with type 2 diabetes mellitus (T2DM) and a first acute ischemic stroke (AIS).
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Ioannis Kyriazis, Konstantinos Sgouros, Dimitra Stefani, Kalliopi Vallianou, Panagiotis Georgakopoulos, Ioannis Tsamis, Sophia Petropoulou, Ioannis Kachrimanidis, Kosntantina Kyre, Athanasios Drosos, Moyssis Lelekis Source Type: research
Glucagon-like peptide-1 agonists and protection against stroke: A systematic review and meta-analysis
Aim: Type 2 diabetes is associated with an increased risk of stroke and a worse outcome following stroke. Among glucose-lowering modalities only pioglitazone (a thiazolinedione) has been shown to protect against stroke. Nonetheless, evidence from experimental with novel antidiabetic agents, such as glucagon-like peptide-1 (GLP-1) agonists, suggests potential neuroprotective effects, especially if treatment starts before stroke. Thus, we aimed to meta-analyze available evidence regarding the risk of stroke in individuals receiving GLP-1 agonists.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Fotios Barkas, Moses Elisaf, Haralampos Milionis Source Type: research
Screening for unknown hypercholesterolemia in a hospital population: A model for preventive medicine
Aim: The autosomal dominant hypercholesterolemia (ADH) is one of the most frequent monogenic diseases and it ’s strongly related to cardiovascular disease (myocardial infarction, stroke).Genes classically associated with ADH are LDL receptor gene (Familial hypercholesterolemia or FH), Apo B gene (Familial Detective ApoB or FDB) and PCSK9 (FH3). The frequency of heterozygous FH is estimated to be approxim ately 1/200 - 1/500 in general population; so, this disease is one of the most common monogenic syndromes.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Roberto Scicali, Roberta Platania, Giacomo Purrazzo, Alberto Giannone, Viviana Ferrara, Francesca Urbano, Agnese Filippello, Salvo Piro, Maria Agata Rabuazzo, Emanuele Farrugia, Venerando Rapisarda, Francesco Purrello Source Type: research
