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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Monocyte subsets, T cell activation profiles, and stroke in men and women: The Multi-Ethnic Study of Atherosclerosis and Cardiovascular Health Study
Despite mechanistic data implicating unresolving inflammation in stroke pathogenesis, data regarding circulating immune cell phenotypes – key determinants of inflammation propagation versus resolution – and incident stroke. Therefore, we aimed to comprehensively define associations of circulating immune phenotypes and activation profiles with incident stroke.
Source: Atherosclerosis - May 14, 2022 Category: Cardiology Authors: Matthew J. Feinstein, Petra Buzkova, Nels C. Olson, Margaret F. Doyle, Colleen M. Sitlani, Alison E. Fohner, Sally A. Huber, James Floyd, Arjun Sinha, Edward B. Thorp, Alan Landay, Matthew S. Freiberg, William T. Longstreth, Russell P. Tracy, Bruce M. Psa Source Type: research
Comparative mortality according to peripheral artery disease and coronary heart disease/stroke in the United States
A recent trial reported that patients with peripheral artery disease (PAD) without coronary heart disease or stroke (CHD/stroke) had worse prognosis than those with CHD/stroke without PAD. However, community-based data are lacking. The purpose of this study was to compare mortality according to the status of PAD and CHD/stroke in the general population.
Source: Atherosclerosis - May 8, 2022 Category: Cardiology Authors: Kunihiro Matsushita, Yumin Gao, Yingying Sang, Shoshana H. Ballew, Maya Salameh, Matthew Allison, Elizabeth Selvin, Josef Coresh Source Type: research
Metabolomics on vascular events and death after acute ischemic stroke: Aprospective matched nested case-control study
Ischemic stroke is a major contributor to global mortality and disability. Metabolomics represents a powerful tool for discovering biomarkers of ischemic stroke due to its ability to detect metabolites small enough to cross the blood –brain barrier. The aim of this study is to identify potential metabolic biomarkers for predicting 1-year vascular events and death after acute ischemic stroke (AIS).
Source: Atherosclerosis - May 6, 2022 Category: Cardiology Authors: Chaofu Ke, Mengyao Shi, Daoxia Guo, Zhengbao Zhu, Chongke Zhong, Tan Xu, Yanqiang Lu, Yi Ding, Yonghong Zhang Source Type: research
Metabolomics on vascular events and death after acute ischemic stroke: A prospective matched nested case-control study
Ischemic stroke is a major contributor to global mortality and disability. Metabolomics represents a powerful tool for discovering biomarkers of ischemic stroke due to its ability to detect metabolites small enough to cross the blood –brain barrier. The aim of this study is to identify potential metabolic biomarkers for predicting 1-year vascular events and death after acute ischemic stroke (AIS).
Source: Atherosclerosis - May 6, 2022 Category: Cardiology Authors: Chaofu Ke, Mengyao Shi, Daoxia Guo, Zhengbao Zhu, Chongke Zhong, Tan Xu, Yanqiang Lu, Yi Ding, Yonghong Zhang Source Type: research
Frequent drinking is more predictive of ischemic stroke than binge drinking, but not of myocardial infarction
Alcohol consumption has complex effects on myocardial infarction (MI) and ischemic stroke. We investigated the difference in associations according to drinking patterns (drinking frequency vs. amount per occasion) and sex.
Source: Atherosclerosis - April 24, 2022 Category: Cardiology Authors: In Young Cho, Jung Eun Yoo, Kyungdo Han, Dahye Kim, Su-Min Jeong, Sungeun Hwang, Heesun Lee, Keun Hye Jeon, Dong Wook Shin Source Type: research
Intracranial atherosclerosis in pseudoxanthoma elasticum: A case-control study
Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by systemic calcification of elastin fibers. Additionally, PXE is associated with an increased risk of stroke. It has been hypothesized that this may be caused by accelerated (intracranial) atherogenesis, as a consequence of specific genetic mutations underlying PXE. Hence, we compared the distribution and burden of intracranial atherosclerosis between PXE patients and healthy controls.
Source: Atherosclerosis - April 15, 2022 Category: Cardiology Authors: Carlo Lucci, Tim C. van den Beukel, Jonas W. Bartstra, Jaco Zwanenburg, Anja van der Kolk, Richard Takx, Jeroen Hendrikse, Mirjam I. Geerlings, Daniel Bos, Wilko Spiering, Pim A. de Jong Source Type: research
Generation of cardio-protective antibodies after pneumococcal polysaccharide vaccine: Early results from a randomised controlled trial
Observational studies have demonstrated that the pneumococcal polysaccharide vaccine (PPV) is associated with reduced risk of cardiovascular events. This may be mediated through IgM antibodies to OxLDL, which have previously been associated with cardioprotective effects. The Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE) is a double-blind, randomised controlled trial (RCT) of PPV in preventing ischaemic events. Participants received PPV or placebo once at baseline and are being followed-up for incident fatal and non-fatal myocardial infarction or stroke over 6 years.
Source: Atherosclerosis - March 5, 2022 Category: Cardiology Authors: Shu Ren, Philip M. Hansbro, Wichat Srikusalanukul, Jay C. Horvat, Tegan Hunter, Alexandra C. Brown, Roseanne Peel, Jack Faulkner, Tiffany-Jane Evans, Shu Chuen Li, David Newby, Alexis Hure, Walter P. Abhayaratna, Sotirios Tsimikas, Ayelet Gonen, Joseph L. Source Type: research
Active factor XI is associated with the risk of cardiovascular events in stable coronary artery disease patients
Tissue factor (TF) and activated factor XI (FXIa) have been associated with acute coronary syndrome, ischemic stroke and venous thromboembolism. Their predictive value in stable coronary artery disease (CAD) is unclear. We investigated whether active TF and FXIa were associated with clinical outcomes in CAD patients in long-term observation.
Source: Atherosclerosis - February 10, 2022 Category: Cardiology Authors: El żbieta Paszek, Elżbieta Pociask, Michał Ząbczyk, Adam Piórkowski, Saulius Butenas, Jacek Legutko, Anetta Undas Source Type: research
Novel insights into lipoprotein(a): News from Atherosclerosis
Lipoprotein(a) [Lp(a)] has had a varied history. While numerous epidemiologic studies documented an association of elevated Lp(a) levels with increased risk of cardiovascular disease [1], it was not until the advent of genetic studies, especially those using a Mendelian randomization design, that the association with cardiovascular outcomes, including myocardial infarction (MI) and ischaemic stroke, as well as aortic valve stenosis, was demonstrated [2 –10]. Collectively, these findings prompted expert reappraisal and reconsideration of Lp(a) in clinical guidelines [11–13] and catalysed the development of novel therape...
Source: Atherosclerosis - February 7, 2022 Category: Cardiology Authors: Jane Stock Source Type: research
Baseline or 90-day fibrinogen levels and long-term outcomes after ischemic stroke or TIA: Results from the China national stroke registry Ⅲ
Elevated fibrinogen levels have been observed in patients with acute ischemic stroke, but the association of fibrinogen with stroke outcomes is still undefined. We aimed to assess the association between baseline or 90-day fibrinogen levels and long-term outcomes in patients with ischemic stroke or transient ischemic attack (TIA).
Source: Atherosclerosis - October 18, 2021 Category: Cardiology Authors: Hui-Qing Hou, Xiang-Long Xiang, Yue-Song Pan, Qi-Hui Zhang, Hao Li, Xia Meng, Yong-Jun Wang Source Type: research
Intracranial carotid artery calcification subtype and collaterals in patients undergoing endovascular thrombectomy
Distinct subtypes of intracranial carotid artery calcification (ICAC) have been found (i.e., medial and intimal), which may differentially be associated with the formation of collaterals. We investigated the association of ICAC subtype with collateral status in patients undergoing endovascular thrombectomy (EVT) for ischemic stroke. We further investigated whether ICAC subtype modified the association between collateral status and functional outcome.
Source: Atherosclerosis - October 13, 2021 Category: Cardiology Authors: Sven P.R. Luijten, Sophie C. van der Donk, Kars C.J. Compagne, Lonneke S.F. Yo, Marieke E.S. Sprengers, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Wim H. van Zwam, Robert van Oostenbrugge, Diederik W.J. Dippel, Aad van der Lugt, Bob Roozenbeek, Daniel Bos, Source Type: research
Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study
The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort.
Source: Atherosclerosis - September 2, 2021 Category: Cardiology Authors: Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada, for the Japan Public Health Center-based Prospective Study Group Source Type: research
Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort
It remains unclear whether extreme levels of blood urea nitrogen (BUN) and BUN to creatinine ratio (BUN/Cr) can increase future risk of stroke. We conducted this study to investigate the associations of BUN and BUN/Cr with incident stroke and its subtypes.
Source: Atherosclerosis - August 5, 2021 Category: Cardiology Authors: Rong Peng, Kang Liu, Wending Li, Yu Yuan, Rundong Niu, Lue Zhou, Yang Xiao, Hui Gao, Handong Yang, Chun Zhang, Xiaomin Zhang, Meian He, Tangchun Wu Source Type: research
Plasma osteopontin levels and adverse clinical outcomes after ischemic stroke
Osteopontin is implicated in atherosclerosis, and its expression is upregulated in response to brain injury. The aim of this study was to prospectively investigate the associations between plasma osteopontin levels and adverse clinical outcomes in ischemic stroke patients.
Source: Atherosclerosis - July 29, 2021 Category: Cardiology Authors: Zhengbao Zhu, Yan He, Mengyao Shi, Daoxia Guo, Kaixin Zhang, Liyun Ren, Yanbo Peng, Pinni Yang, Jing Chen, Yuhan Zang, Aili Wang, Tan Xu, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He Source Type: research
Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at rISK (PARISK) study
Lipoprotein(a) is an independent risk factor for cardiovascular disease and recurrent ischemic stroke. Lipoprotein(a) levels are known to be associated with carotid artery stenosis, but the relation of lipoprotein(a) levels to carotid atherosclerotic plaque composition and morphology is less known. We hypothesize that higher lipoprotein(a) levels and lipoprotein(a)-related SNPs are associated with a more vulnerable carotid plaque and that this effect is sex-specific.
Source: Atherosclerosis - June 10, 2021 Category: Cardiology Authors: Dianne H.K. van Dam-Nolen, Anouk C. van Dijk, Genevi ève C. Crombag, Carlo Lucci, M. Eline Kooi, Jeroen Hendrikse, Paul J. Nederkoorn, Mat J.A.P. Daemen, Antonius F.W. van der Steen, Peter J. Koudstaal, Florian Kronenberg, Jeanine E. Roeters van Lennep, Source Type: research
