Intracranial atherosclerosis in pseudoxanthoma elasticum: A case-control study

Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by systemic calcification of elastin fibers. Additionally, PXE is associated with an increased risk of stroke. It has been hypothesized that this may be caused by accelerated (intracranial) atherogenesis, as a consequence of specific genetic mutations underlying PXE. Hence, we compared the distribution and burden of intracranial atherosclerosis between PXE patients and healthy controls.

Source: Atherosclerosis - April 15, 2022 Category: Cardiology Authors: Carlo Lucci, Tim C. van den Beukel, Jonas W. Bartstra, Jaco Zwanenburg, Anja van der Kolk, Richard Takx, Jeroen Hendrikse, Mirjam I. Geerlings, Daniel Bos, Wilko Spiering, Pim A. de Jong Source Type: research