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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Upstream high wall shear stress associated with artery-to-artery embolism and recurrent stroke in symptomatic intracranial atherosclerotic stenosis
Background and Aims: To investigate associations of local wall shear stress (WSS) with artery-to-artery embolism (AAE) and risk of stroke recurrence, in symptomatic intracranial atherosclerotic stenosis (sICAS).
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Li, L. Lan, X. Tian, H. Liu, B. Ip, S.H. Ma, J. Abrigo, Y. Liu, Y. Liu, K. Ma, F. Fan, V. Ip, Y. Soo, A. Lau, H. Leung, V. Mok, T. Leung, X. Leng Source Type: research
Wall shear stress associated with stroke occurrence and mechanism in middle cerebral artery atherosclerosis
Background and Aims: Various mechanisms are involved in stroke caused by atherosclerosis of the middle cerebral artery (MCA). However, the factors that affect stroke mechanism are unclarified. Here, we compared plaque nature and hemodynamic parameters according to stroke mechanism in patients with MCA atherosclerosis.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: B.J. Kim, H.G. Woo Source Type: research
Differences in the peripheral immune cell landscape in atherosclerosis – Insights from the LURIC single cell RNA-sequencing study (LURNA)
Background and Aims: Atherosclerosis and its clinical sequelae, myocardial infarction and stroke, represent the main causes of death worldwide. Although preclinical evidence has suggested the existence of a sustained inflammatory and immune response driving disease and complications, the extend of cellular alterations in human atherosclerosis remains enigmatic. Here, we employ single cell RNA-sequencing (scRNA-seq) on peripheral blood mononucleated cells in a well-defined cardiovascular risk cohort from the the LURIC trial to define changes in the immune cell landscape in atherosclerotic patients.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Horstmann, N. Anto-Michel, X. Sheng, S. Hansen, D. Westermann, W. M ärz, A. Zirlik, D. Wolf Source Type: research
Prevalence and risk factors of intracranial and extracranial atherosclerotic stenosis in Chinese patients with acute minor stroke or transient ischemic attack
Background and Aims: To investigate differences in prevalence and risk factors between intracranial and extracranial atherosclerotic stenosis (ICAS and ECAS) in patients with acute minor stroke or transient ischemic attack (TIA).
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: X. Tian, B. Ip, S. Li, Y. Liu, K.L. Chan, Y. Liu, S. Huang, K. Ma, S.H. Ma, F. Fan, V. Ip, Y. Soo, A. Lau, H. Leung, V. Mok, T. Leung, X. Leng Source Type: research
Obesity and the risk of ischemic stroke in patients with atrial fibrillation: Findings from a big data analysis
Background and Aims: The use of big data analysis makes it easier to assess the contribution of individual risk factors to the prognoses, compared with large-scale epidemiological studies.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: V. Korneva, M. Druzhilov, T. Kuznetsova, D. Gavrilov, A. Gusev Source Type: research
Inflammation and dyslipidaemia as the additional risk for stroke in patients with atrial fibrillation
Background and Aims: Atrial fibrillation (AF) is often accompanied by complications, especially ischemic stroke. AF is associated with atrial structural changes that may have an inflammatory basis. Dyslipidemia is the basis for the development of atherosclerotic diseases, their role in the development of AF is not entirely clear, and previous studies suggest a "cholesterol paradox". The aim of this study is to investigate the relationship between inflammation markers and dyslipidemia risk in patients with AF and stroke
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Grigoryan, A. Stepanyan, P. Zelveian, L. Hazarapetyan Source Type: research
Tangier disease in Israel; Complicated by mobile lipomatous mass on mitral valve and acute stroke
Background and Aims: Tangier disease (TD) is a rare genetic disease which causes very low or even deficient HDL in plasma and accumulation of cholesterol in different tissues throughout the body. The disease is related to early onset of atherosclerotic disease and other clinical sequelae, previous articles described increased incidence of stroke in tangier patients. Valvular involvement in Tangier's disease was never described before .
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: R. Durst, S. Shpitzen, M. Mowaswes, D. Schurr, E. Leitersdorf Source Type: research
Lipoprotein(a), lymphocyte-monocyte ratio and progression of carotid atherosclerosis
Background and Aims: Lipoprotein(a) [Lp(a)] is an independent risk factor for carotid atherosclerosis and ischemic stroke, leading to the induction and maintenance of systemic inflammation. The ratio of different leukocyte subpopulations is the most available marker of systemic inflammation. The aim of the study was to evaluate the association of Lp(a) and lymphocyte monocyte ratio (LMR) with the progression of carotid atherosclerosis
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: O. Afanasieva, A. Tyurina, O. Pogorelova, E. Klesareva, M. Ezhov, S. Pokrovsky Source Type: research
Regulation of NC886 RNAs is associated with cardiometabolic risk factors, death and stroke
Background and Aims: Non-coding 886 is a unique polymorphically imprinted gene (Figure1). Its methylation status has been suggested to mediate DOHaD/Barker ’s hypothesis. We have previously shown that both nc886 methylation status and genetics have an independent effect on nc886 RNA levels. Here we have combined this information to predict lifelong nc886 RNA levels and study their association to cardiometabolic diseases (CMDs)
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Raji ć, S. Marttila, N. Hutri-Kähönen, M. Kähönen, T. Lehtimäki, L.-P. Lyytikäinen, P. Mishra, N. Mononen, O. Raitakari, M. Waldenberger, T. Delerue, W. März, M. Kleber, E. Harville, R. Zhang, E. Raitoharju Source Type: research
The attenuated metabolic suppression and elevated mTOR levels in replicatively aged fibroblasts may contribute to atherosclerosis in Hutchinson Gilford Progeria
Background and Aims: Hutchinson Gilford Progeria (HGP) is characterized by accelerated aging and premature death caused by myocardial infarction or stroke. Enhanced metabolism and proliferation may accelerate senescence entry and atherogenesis. We therefore related cellular proliferation and exogenous stress to mTOR signaling in four control and four HGP fibroblast cell lines.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: J. Mensch, K. J äger, M. Grimmig, A. Hartmann, M. Walter Source Type: research
Triglyceride-lowering therapy for the prevention of cardiovascular events, stroke, and mortality in patients with diabetes: A meta-analysis of randomized controlled trials
Triglyceride (TG)-lowering therapy is efficient for the prevention of cardiovascular disease (CVD) in the general population; however, for diabetic individuals, it is more controversial. The purpose of this study was to pool the results from randomized controlled trials (RCTs) to clarify whether the lowering of TG is beneficial for the prevention of CVD events, stroke, and mortality in subjects with diabetes.
Source: Atherosclerosis - July 12, 2023 Category: Cardiology Authors: Xiu Hong Yang, Qian Ming Tu, Li Li, Yong Ping Guo, Nian Song Wang, Hui Min Jin Source Type: research
Reply to “Correspondence to: Association of remnant cholesterol with risk of cardiovascular disease events, stroke, and mortality: A systemic review and meta-analysis”
We sincerely appreciate Dr. Athanasopoulou ’ s comments in response to our meta-analysis [1]. We agree with most of his opinions and would like to clarify our views here.
Source: Atherosclerosis - June 22, 2023 Category: Cardiology Authors: Xiu Hong Yang, Bao Long Zhang, Hui Min Jin Tags: Correspondence Source Type: research
Sex differences in the association between stroke risk factors and pre-clinical predictors of stroke in the childhood determinants of Adult Health study
We examined these associations with carotid artery structure and function in a prospective cohort study.
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Mohammad Shah, Marie-Jeanne Buscot, Jing Tian, Hoang T. Phan, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall Source Type: research
Correspondence to: “Association of remnant cholesterol with risk of cardiovascular disease events, stroke, and mortality: A systemic review and meta-analysis”
We read with great interest the paper by Yang et al. published in Atherosclerosis, reporting that remnant cholesterol (RC) levels are associated with increased risk of adverse cardiovascular events, stroke and mortality [1]. Given the recent advances in hypolipidemic treatments, RC has been brought to the spotlight as a potential prognostic and therapeutic biomarker of residual atherosclerotic cardiovascular disease risk (ASCVD) beyond LDL-C [2,3]. Therefore, these findings are of clinical relevance and support the clinical applicability of RC in this setting.
Source: Atherosclerosis - June 5, 2023 Category: Cardiology Authors: Elpida Athanasopoulou, Athanase D. Protogerou Tags: Correspondence Source Type: research
Plasma TSH and cardiovascular disease in the general population: A mendelian randomization study of 105,224 individuals
The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - May 23, 2023 Category: Cardiology Authors: Nawar Dalila, Ruth Frikke-Schmidt, B ørge G. Nordestgaard, Anne Tybjærg-Hansen Source Type: research
