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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Prediction of new-onset atrial fibrillation after first-ever ischemic stroke: A comparison of CHADS2, CHA2DS2-VASc and HATCH scores and the added value of stroke severity
Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2, CHA2DS2-VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding stroke severity to the risk scores improves predictive performance.
Source: Atherosclerosis - March 15, 2018 Category: Cardiology Authors: Cheng-Yang Hsieh, Cheng-Han Lee, Darren Philbert Wu, Sheng-Feng Sung Source Type: research
New methods to image unstable atherosclerotic plaques
Atherosclerotic plaque rupture is the primary mechanism responsible for myocardial infarction and stroke, the top two killers worldwide. Despite being potentially fatal, the ubiquitous prevalence of atherosclerosis amongst the middle aged and elderly renders individual events relatively rare. This makes the accurate prediction of MI and stroke challenging. Advances in imaging techniques now allow detailed assessments of plaque morphology and disease activity. Both CT and MR can identify certain unstable plaque characteristics thought to be associated with an increased risk of rupture and events.
Source: Atherosclerosis - March 14, 2018 Category: Cardiology Authors: Jack P.M. Andrews, Zahi A. Fayad, Marc R. Dweck Tags: Review article Source Type: research
CD137: A checkpoint regulator involved in atherosclerosis
Inflammation is associated with atherosclerotic plaque development and precipitation of myocardial infarction and stroke, and anti-inflammatory therapy may reduce disease severity. Costimulatory molecules are key regulators of immune cell activity and inflammation, and are associated with disease development in atherosclerosis. Accumulating evidence indicates that a costimulatory molecule of the Tumor Necrosis Factor Receptor Superfamily, the checkpoint regulator CD137, promotes atherosclerosis and vascular inflammation in experimental models.
Source: Atherosclerosis - March 5, 2018 Category: Cardiology Authors: Leif Å. Söderström, Laura Tarnawski, Peder S. Olofsson Tags: Review article Source Type: research
Carotid atherosclerosis and risk for ischemic stroke in patients with atrial fibrillation on oral anticoagulant treatment
Whether carotid atherosclerosis is associated with an increased risk for ischemic stroke in patients with atrial fibrillation (AF) on anticoagulant treatment is undefined. To explore this association, patients with AF on treatment with vitamin K antagonists were included in a multicenter, prospective study.
Source: Atherosclerosis - February 22, 2018 Category: Cardiology Authors: Cecilia Becattini, Francesco Dentali, Giuseppe Camporese, Agnese Sembolini, Elena Rancan, Chiara Tonello, Giorgia Manina, Seena Padayattil, Giancarlo Agnelli Source Type: research
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke
Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased in acute ischemic stroke and its etiologic subgroups and they correlate with stroke severity.
Source: Atherosclerosis - February 8, 2018 Category: Cardiology Authors: Frederick Palm, Pirkko J. Pussinen, Anton Safer, Taina Tervahartiala, Timo Sorsa, Christian Urbanek, Heiko Becher, Armin J. Grau Source Type: research
Atherosclerotic intracranial internal carotid artery calcification and intravenous thrombolytic therapy for acute ischemic stroke
Intracranial internal carotid artery calcification (IICAC) is a frequent and readily available finding in acute stroke patients treated with intravenous (IV) tissue plasminogen activator (tPA). We aimed to investigate the effects of IICAC subtype (medial and intimal) on the response to IV tPA.
Source: Atherosclerosis - January 31, 2018 Category: Cardiology Authors: Rahsan Gocmen, Ethem Murat Arsava, Kader Karli Oguz, Mehmet Akif Topcuoglu Source Type: research
The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: The SOS-Stroke Study
Oxidized low-density lipoprotein (oxLDL) has a defined role in the genesis and development of atherosclerosis, however, whether it is related to severity of neurological deficits is rarely reported. The aim of our study was to investigate the potential association between oxLDL and the National Institutes of Health Stroke Scale (NIHSS) score among patients with acute ischemic stroke.
Source: Atherosclerosis - January 21, 2018 Category: Cardiology Authors: Anxin Wang, Ying Cui, Xia Meng, Zhaoping Su, Yibin Cao, Yuling Yang, Changcheng Liu, Liye Dai, Youxin Wang, Yilong Wang Source Type: research
Total cholesterol and the risk of stroke: A double-edged sword or a blunt knife?
Hypercholesterolemia is a major risk factor for ischemic stroke [1]. Although cholesterol- ‐lowering therapies such as statins have consistently shown reduction in the risk of ischemic stroke, concerns have been raised about the accompanied risk of hemorrhagic stroke, mainly including intracerebral hemorrhage (ICH) [2,3]. Indeed, earlier observational data also suggested low total serum cholesterol (TC) as a risk factor for ICH [4,5]. Hence, would low TC levels have a role in stroke like a double-edged sword, by decreasing the risk of ischemic stroke and increasing the risk of ICH?
Source: Atherosclerosis - January 17, 2018 Category: Cardiology Authors: Luiz S érgio F. de Carvalho Tags: Editorial Source Type: research
Assessment of extracranial and intracranial atherosclerosis: Don't dismiss old school autopsy
Atherosclerotic disease represents one of the leading causes of ischemic stroke worldwide, posing a major global public health concern [1]. The prevalence of patients with intracranial atherosclerotic disease (IAD) exceeds those of patients with extracranial atherosclerotic disease (EAD) [2]. Risk factors for IAD and EAD have been shown to differ, the former has for example been related to obesity and hyperlipidemia whereas the latter has been associated with hypertension, though not all studies concur [3].
Source: Atherosclerosis - January 17, 2018 Category: Cardiology Authors: Jacobus F.A. Jansen Tags: Editorial Source Type: research
Total cholesterol and the risk of stroke: A double-edged sword or a blunt knife?
Hypercholesterolemia is a major risk factor for ischemic stroke [1]. Although cholesterol-lowering therapies such as statins have consistently shown reduction in the risk of ischemic stroke, concerns have been raised about the accompanied risk of hemorrhagic stroke, mainly including intracerebral hemorrhage (ICH) [2,3]. Indeed, earlier observational data also suggested low total serum cholesterol (TC) as a risk factor for ICH [4,5]. Hence, would low TC levels have a role in stroke like a double-edged sword, by decreasing the risk of ischemic stroke and increasing the risk of ICH?
Source: Atherosclerosis - January 17, 2018 Category: Cardiology Authors: Luiz S érgio F. de Carvalho Tags: Editorial Source Type: research
Stroke outcome is associated with baseline renal function: A risk factor that matters!
Kidney disease and more specifically chronic kidney disease (CKD) prevalence is on the rise and it is estimated that the prevalence of CKD is almost 11 –13% in the world [1]. During the last twenty years, a number of studies have shown that patients with CKD have a higher risk for cardiovascular events including stroke and myocardial infarction [2–5]. Furthermore, CKD has been associated with an increased risk for all mortality and cardiovascul ar (CV) mortality [6]. In light of this, it is not surprising that in this issue of Atherosclerosis Wang et al.
Source: Atherosclerosis - January 12, 2018 Category: Cardiology Authors: Joy Roy Tags: Editorial Source Type: research
The association between plasma endotoxin, endotoxin pathway proteins and outcome after ischemic stroke
In animals. peripheral lipopolysaccharide (LPS) injection before cerebral ischemia exacerbates neurological deficit, impairs survival and augments sickness behaviour. The goal of our study was to determine a relationship between plasma LPS, LPS pathway proteins (LPS binding protein (LBP) and sCD14) and outcome in stroke patients.
Source: Atherosclerosis - December 27, 2017 Category: Cardiology Authors: Elzbieta Klimiec, Paulina Pasinska, Katarzyna Kowalska, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic Source Type: research
