CD137: A checkpoint regulator involved in atherosclerosis

Inflammation is associated with atherosclerotic plaque development and precipitation of myocardial infarction and stroke, and anti-inflammatory therapy may reduce disease severity. Costimulatory molecules are key regulators of immune cell activity and inflammation, and are associated with disease development in atherosclerosis. Accumulating evidence indicates that a costimulatory molecule of the Tumor Necrosis Factor Receptor Superfamily, the checkpoint regulator CD137, promotes atherosclerosis and vascular inflammation in experimental models.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Review article Source Type: research