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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Effectiveness of Internet-based health management in patients with dyslipidemia: A four-year longitudinal study
This study was conducted to provide health guidance and education to people with dyslipidemia using an Internet health management platform and to assess the effectiveness of Internet health management and intervention in improving health-related behaviors and controlling blood lipids.
Source: Atherosclerosis - May 7, 2023 Category: Cardiology Authors: Yuqi Dou, Botian Chen, Xue Yu, Defu Ma Source Type: research
Association of remnant cholesterol with risk of cardiovascular disease events, stroke, and mortality: A systemic review and meta-analysis
Lipid disorders are associated with the risk of cardiovascular diseases (CVDs). Remnant cholesterol (RC), a non-traditional previously neglected risk factor for CVD, has received much attention in recent years. The aim of this study is to evaluate the association of RC with the risks of CVD, stroke, and mortality.
Source: Atherosclerosis - March 20, 2023 Category: Cardiology Authors: Xiu Hong Yang, Bao Long Zhang, Yun Cheng, Shun Kun Fu, Hui Min Jin Tags: Review article Source Type: research
Differential association between apolipoprotein B and LDL cholesterol and cerebral atherosclerosis according to pre-stroke statin use
To reduce cardiovascular risk, low-density lipoprotein cholesterol (LDL-C) is the primary target of statin treatment, while apolipoprotein B (ApoB) is secondary. We investigated the association between atherosclerotic stenosis and LDL-C or ApoB levels and whether a difference in association exists according to pre-admission statin use in ischemic stroke patients.
Source: Atherosclerosis - March 19, 2023 Category: Cardiology Authors: Minyoul Baik, Hyo Suk Nam, Ji Hoe Heo, Hye Sun Lee, Young Dae Kim Source Type: research
Artificial intelligence for high-risk plaque detection on carotid CT angiography
Atherothrombotic events such as myocardial infarction and stroke most commonly arise from the disruption of plaques that pathologically exhibit a large lipid-rich core, thin fibrous cap, and outward remodeling [1,2]. These high-risk morphological ‘vulnerable plaque’ features can be identified early by invasive and non-invasive imaging modalities [3], and their presence portends an increased lesion-specific and patient-level risk of future cardiovascular events [4–7]. In this issue of Atherosclerosis, Buckler et al.
Source: Atherosclerosis - January 14, 2023 Category: Cardiology Authors: Andrew Lin Tags: Editorial Source Type: research
Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis
Carotid atherosclerosis is an important cause of ischemic stroke. Lipids play a key role in the progression of atherosclerosis. To date, the spatial lipid profile of carotid atherosclerotic plaques related to histology has not been systematically investigated.
Source: Atherosclerosis - November 23, 2022 Category: Cardiology Authors: Wei Li, Jichang Luo, Fangda Peng, Ruiting Liu, Xuesong Bai, Tao Wang, Xiao Zhang, Junge Zhu, Xu-Ying Li, Zhanjun Wang, Wubin Liu, Jiyue Wang, Liyong Zhang, Xianyang Chen, Teng Xue, Chunguang Ding, Chaodong Wang, Liqun Jiao Source Type: research
Lipoprotein(a) and cardiovascular disease: Make use of the knowledge we have
There is strong evidence that Lp(a) is a causal risk factor for cardiovascular disease [1]. This includes outcomes such as coronary artery disease, aortic valve stenosis, ischemic stroke, peripheral arterial disease, cardiovascular mortality and heart failure as recently reviewed by Arsenault and Kamstrup [2]. The most recent European Atherosclerosis Society Lp(a) Consensus Statement provides data from the UK Biobank which clearly demonstrates that there is a continuous relationship between increasing Lp(a) concentrations and increasing risk for these outcomes [1] (see Fig.
Source: Atherosclerosis - November 22, 2022 Category: Cardiology Authors: Florian Kronenberg Tags: Editorial Source Type: research
Genetic proxies for PCSK9 inhibition associate with lipoprotein(a): Effects on coronary artery disease and ischemic stroke
Post hoc analyses of clinical trials show that PCSK9 inhibitors might lower lipoprotein(a), but whether this effect contributes to reductions in cardiovascular risk remains unknown. We aimed to assess whether genetically proxied PCSK9 inhibition influences lipoprotein(a) (Lp(a)), and whether any such effect could mediate its effects on coronary artery disease (CAD) and ischemic stroke (IS).
Source: Atherosclerosis - September 25, 2022 Category: Cardiology Authors: Gian Marco De Marchis, Tolga D. Dittrich, Rainer Malik, Annaelle V. Zietz, Lilian F. Kriemler, Brian A. Ference, Martin Dichgans, Marios K. Georgakis Source Type: research
Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study
Identifying individuals at elevated risk for mortality, especially from cardiovascular disease, may help guide testing and treatment. Risk factors for mortality differ by sex and race. We investigated the association of growth hormone (GH) with all-cause and cardiovascular mortality in a racially diverse cohort in the United States.
Source: Atherosclerosis - September 13, 2022 Category: Cardiology Authors: Nicholas Wettersten, Rohit Mital, Mary Cushman, George Howard, Suzanne E. Judd, Virginia J. Howard, Monika M. Safford, Oliver Hartmann, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research
Lipoprotein(a) variability over time in adult lipid clinic patients
Lipoprotein(a) (Lp[a]) is a low-density lipoprotein (LDL)-like particle in which apolipoprotein (apo) B is covalently bound to a plasminogen-like molecule called apo(a) [1]. Elevated plasma Lp(a) concentration is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, stroke and cardiac death [1]. The European Atherosclerosis Society, European Society of Cardiology and Canadian Cardiovascular Society (CCS) dyslipidemia guidelines recommend measurement of Lp(a) once in an individual's lifetime to identify patients with high levels who would benefit from earlier, more i...
Source: Atherosclerosis - September 5, 2022 Category: Cardiology Authors: Isabel Shamsudeen, Robert A. Hegele Tags: Correspondence Source Type: research
Risk of stroke in genetically verified familial hypercholesterolemia: A prospective matched cohort study
Individuals with familial hypercholesterolemia (FH), causing severely elevated LDL-C, are expected to have a higher risk of ischemic stroke. The risk of hemorrhagic stroke and impact of statin use is however not known. We aimed to investigate the risk of incident total, ischemic and hemorrhagic stroke in individuals with FH compared to controls and to explore the association between cumulative statin use and risk of total stroke in FH.
Source: Atherosclerosis - August 27, 2022 Category: Cardiology Authors: Karianne Svendsen, Thomas Olsen, Kathrine J. Vinknes, Liv J. Mundal, Kirsten B. Holven, Martin P. Bogsrud, Trond P. Leren, Jannicke Igland, Kjetil Retterst øl Source Type: research
Effective high-density lipoprotein cholesterol is associated with carotid intima-media thickness and vascular events after acute ischemic stroke
Effective high density lipoprotein cholesterol (HDL-C) is a measure of HDL functionality. We evaluated if HDL-C is associated with carotid intima-media thickness (cIMT) and incident major adverse cardiovascular events (MACE) in patients with acute ischemic stroke from two prospective cohort studies.
Source: Atherosclerosis - August 6, 2022 Category: Cardiology Authors: Edzard Schwedhelm, Steffen Tiedt, Susanne Lezius, Teresa Allegra W ölfer, Märit Jensen, Robert Schulz, Rainer Böger, Christian Gerloff, Götz Thomalla, Chi-un Choe Source Type: research
International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches
Cardiovascular disease (CVD) is the leading cause of mortality and disability in developed countries. According to WHO, an estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to major adverse cardiac and cerebral events. Early detection and care for individuals at high risk could save lives, alleviate suffering, and diminish economic burden associated with these diseases.Carotid artery disease is not only a well-established risk factor for ischemic stroke, contributing to 10% –20% of strokes or transient ischemic attacks (TIAs), but it is also a surro...
Source: Atherosclerosis - June 27, 2022 Category: Cardiology Authors: Luca Saba, Pier Luigi Antignani, Ajay Gupta, Riccardo Cau, Kosmas I. Paraskevas, Pavel Poredos, Bruce Wasserman, Hooman Kamel, Efthymios D. Avgerinos, Rodrigo Salgado, Federico Caobelli, Leonardo Aluigi, Luis Savastano, Martin Brown, Tom Hatsukami, Emad H Tags: Review article Source Type: research
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyse
Mitochondrial dysfunction is associated with increased reactive oxygen species (ROS) that are thought to drive disease risk, including stroke. We investigated the association between mtDNA abundance, as a proxy measure of mitochondrial function, and incident stroke, using multivariable-adjusted survival and Mendelian Randomization (MR) analyses.
Source: Atherosclerosis - June 19, 2022 Category: Cardiology Authors: Leon G. Martens, Jiao Luo, Marieke J.H. Wermer, Ko Willems van Dijk, Sara H ägg, Felix Grassmann, Raymond Noordam, Diana van Heemst Source Type: research
Peripheral artery disease: A highly prevalent untreated and uncontrolled independent cardiovascular disease
Peripheral artery disease (PAD) prevalence is high in developed countries and increasing in low-income ones, involving more than the 20% of subjects older than 80 years in high-income countries [1]. Its diagnosis is, however, yet largely undertaken and delayed, with a large risk to loose the possibility of an effective management [2]. While PAD risk factors are well-known and overlapping with those for coronary artery disease (CAD), the epidemiological association between PAD, CAD/stroke and mortality is yet conflicting.
Source: Atherosclerosis - June 19, 2022 Category: Cardiology Authors: Arrigo F.G. Cicero, Massimo Salvetti Tags: Editorial Source Type: research
Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study
and aims; Glutamine synthetase (GLUL), the sole generator of glutamine, is a metabolic nexus molecule also involved in atherosclerosis. We recently demonstrated a 2.2-fold upregulation of GLUL mRNA in stroke-causing carotid plaques when compared with plaques from asymptomatic patients. Here we compared in the same cohort GLUL mRNA expression with plaque gross morphology, and the colocalization of immunodetectable GLUL protein with histopathological changes and molecular and mechanical mediators linked to plaque development.
Source: Atherosclerosis - May 17, 2022 Category: Cardiology Authors: Pia Sorto, Mikko I. M äyränpää, Jani Saksi, Krista Nuotio, Petra Ijäs, Jarno Tuimala, Pirkka Vikatmaa, Lauri Soinne, Petri T. Kovanen, Perttu J. Lindsberg Source Type: research
