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Source: Atherosclerosis

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Total 436 results found since Jan 2013.

Molecular markers of ischemic stroke associated with atherosclerosis
Background and Aims: The goal is to evaluate the clinical significance of biological markers of the central nervous system in ischemic stroke.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: A. Goloubev, M. Petrova, A. Grechko, V. Zakharchenko, A.N. Kuzovlev Source Type: research

Sodium-glucose transport protein 2 inhibitors and risk of incident stroke: A systematic review and meta-analysis
Background and Aims: Although experimental studies have suggested a potential neuroprotective effect of sodium-glucose contransporter-2 (SGLT2) inhibitors, human trials have demonstrated controversial results regarding their effect on the risk of stroke. In this context, we evaluated published evidence regarding the effect of treatment with SGLT2 inhibitors on the risk of ischemic stroke.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: F. Barkas, E. Liberopoulos, S. Filippas Ntekouan, H. Milionis Source Type: research

Low level of HDL as a predictor of development of new cases of myocardial infarction, stroke and death from cardiovascular diseases in the Belarusian urban population
Background and Aims: The aim of the study was to determine the impact of low HDL level on the development of new cases of myocardial infarction, stroke and death from cardiovascular diseases (CVD) in the Belarusian urban population.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: V. Podpalov, A. Makhankova, Y. Surunovich, O. Zhurova, O. Podpalova, A.D. Deev Source Type: research

3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)
Background and Aims: Intra-plaque angiogenesis (IP), present in advanced human atherosclerotic plaques, promotes unstable vascular disease and contributes to increased risk of myocardial infarction and stroke. Because proliferating endothelial cells (ECs) rely on glycolysis for up to 85% of their energy demand, glycolysis inhibition may represent a novel strategy to prevent IP neovascularization, thereby promoting plaque stabilization. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolysis pathway and plays an essential role in angiogenesis.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: B. Emini Veseli, P. Perrotta, A. Abdali, P. Van Wielendaele, G. Monaco, A.-M. Lambeir, M.L. Gelmi, G. Bultynck, W. Martinet, G. De Meyer Source Type: research

Comparison of warfarin and aspirin for secondary prevention of intracranial arterial stenosis. a systematic review and meta-analysis
Background and Aims: The use of antithrombotic treatment in symptomatic patients with intracranial arterial disease and previous stroke or transient ischemic attack (TIA) is controversial for the secondary prevention of recurrent ischemic cerebral infarction.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: A.P. Evangeliou, A.T. Tzinas, C. Papadopoulos, S. Tzikas Source Type: research

Case report: Hyper Lp(a) and stroke in pediatric patient
Background and Aims: The incidence of stroke in children is low compared to the adult population, however it constitutes one of the 10 most frequent causes of childhood mortality. As for its etiology we must consider structural pathology, hematological, metabolic, infectious diseases and prothrombotic states. Lipoprotein a [Lp (a)] is a variant of LDL with a protein fraction known as apolipoprotein (a). High levels are considered atherogenic because of their implication in the formation of atheromatous plaque and because of fibrinolysis.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: M.B. Araujo, C.D. Flores, E. Ortiz Tolaba Source Type: research

Statins reduce major adverse limb events and mortality in patients with peripheral artery disease
Background and Aims: Statins are guideline recommended in patients with peripheral artery disease (PAD) for prevention of cardiovascular events. However, comprehensive meta-data on the impact of statin therapy on major adverse limb events (MALE) in PAD patients have not been reported. We want to investigate the association of statin use with MALE events, all-cause death, cardiovascular death and stroke in these patients.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: D. Pastori, A. Farcomeni, A. Milanese, F. Del Sole, D. Menichelli, W.R. Hiatt, F. Violi Source Type: research

Patient characteristics and lipoprotein(A) LP(A) values among us patients with established CVD
Background and Aims: To characterize patients with established CVD (defined as MI, ischemic stroke or peripheral artery disease [PAD]) and Lp(a) measurement in terms of comorbidities and all-cause and CV hospitalization rates.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: R. Lahoz, J.H. Heo, A. Laguna, Y. Ding, A.F. Fonseca, D.T. Amari, R. Studer Source Type: research

Hyperlipidemia as a stroke risk factor: Study of patients from northwest of Iran from 2008 to 2013
Background and Aims: Stroke is one of the leading causes of death and disability worldwide; and hyperlipidemia is one of its major risk factors. Hyperlipidemia is reported to have an etiologic role for small-vessel disease, significantly increasing risk of ischemic stroke, as well as having a limited role in intracranial hemorrhage. Dyslipidemia has been long recognized as a risk factor for coronary artery disease but its role in stroke has become increasingly apparent over the past decade.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: N. Parnianfard, S.-R. Sadat-Ebrahimi, P. Hoseini Source Type: research

The protective effect of statins against pressure ulcers in stroke patients: A propensity-score matched study based on a real-world database
Limited information is available regarding the association between statins and pressure ulcers. The purpose of this study is to evaluate the beneficial effects of statins on pressure ulcers in stroke patients.
Source: Atherosclerosis - November 29, 2020 Category: Cardiology Authors: Yu-Chen Huang, Chuen-Chau Chang, Chun-Chieh Yeh, Chao-Shun Lin, Chaur-Jong Hu, Ta-Liang Chen, Chien-Chang Liao Source Type: research

Natural compounds as anti-atherogenic agents: Clinical evidence for improved cardiovascular outcomes
Atherosclerosis, a chronic progressive inflammatory condition characterized by the formation of lipid-laden lesions in arterial walls, is associated with substantial morbidity (including ischaemic stroke and myocardial infarction) and mortality. Risk factors for atherosclerosis are well understood and can be ameliorated by evidence-based and guideline-directed pharmaceutical agents (e.g. the reduction of circulating concentrations of low-density lipoprotein cholesterol by statins). Additionally, many natural products (usually food derivatives) and ‘nutraceuticals’ (pharmaceutical formulations prepared from components o...
Source: Atherosclerosis - November 24, 2020 Category: Cardiology Authors: Peter E. Penson, Maciej Banach Tags: Review article Source Type: research

Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification
The pattern of intracranial internal carotid artery calcification (ICAC) has been identified as an effect modifier of endovascular treatment in patients with acute ischemic stroke, but it is unclear whether it modifies the effect of intravenous thrombolysis. The purpose of this study was to evaluate the association between intravenous thrombolysis and 90-day clinical outcome, follow-up infarct volume, intracranial hemorrhage and recanalization across different patterns of ICAC.
Source: Atherosclerosis - November 22, 2020 Category: Cardiology Authors: Frans Kauw, Pim A. de Jong, Richard A.P. Takx, Hugo W.A.M. de Jong, L. Jaap Kappelle, Birgitta K. Velthuis, Jan W. Dankbaar, Dutch acute stroke study (DUST) investigators Source Type: research

Normalized wall index, intraplaque hemorrhage and ulceration of carotid plaques correlate with the severity of ischemic stroke
Carotid atherosclerosis is considered an important cause of ischemic stroke. Tthis study aimed to explore the relationship between plaque features and the severity of stroke, and to identify plaque risk factors for the assessment of the severity of ischemic stroke.
Source: Atherosclerosis - November 5, 2020 Category: Cardiology Authors: Xin Cao, Qingluan Yang, Ye Tang, Lei Pan, Mao Lai, Zekuan Yu, Daoying Geng, Jun Zhang Source Type: research

Normalized wall index, intraplaque hemorrhage and ulceration of carotid plaques are correlated with the severity of ischemic stroke
Carotid atherosclerosis is considered an important cause of ischemic stroke, this study aimed to explore the relationship between plaque features and the severity of stroke, and to identify plaque risk factors for assessing the severity of ischemic stroke.
Source: Atherosclerosis - November 5, 2020 Category: Cardiology Authors: Xin Cao, Qingluan Yang, Ye Tang, Lei Pan, Mao Lai, Zekuan Yu, Daoying Geng, Jun Zhang Source Type: research

Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomisation study
Observational studies have reported an association between periodontitis and cardiovascular disease but whether this association is causal is uncertain. We therefore used Mendelian randomization to test whether periodontitis is causally associated with stroke, coronary artery disease, or subclinical atherosclerosis.
Source: Atherosclerosis - October 3, 2020 Category: Cardiology Authors: Steven Bell, Joel T. Gibson, Eric L. Harshfield, Hugh S. Markus Source Type: research