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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Hypertension in children: Knowledge is the road to prevention
Hypertension is the most important risk factor for cardiovascular disease and currently affects 25 –35% of the adult population in the most industrialized countries [1]. The high prevalence of hypertension largely contributes to the overall incidence of fatal and non-fatal cardiovascular events that is proportional to the values of systolic and diastolic blood pressure both for coronary heart d isease and stroke [1]. The linear correlation between blood pressure and cardiovascular mortality involves all age groups, with a difference in the absolute event rate that is significantly increased in elderly patients [2].
Source: Atherosclerosis - February 28, 2017 Category: Cardiology Authors: Claudio Borghi Tags: Editorial Source Type: research
Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke
The relationship between liver fibrosis and the occurrence of ischemic stroke is unknown. We investigated the correlation between liver fibrosis assessed with transient elastography (TE) and the risk of ischemic stroke.
Source: Atherosclerosis - February 10, 2017 Category: Cardiology Authors: Seung Up Kim, Dongbeom Song, Ji Hoe Heo, Joonsang Yoo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Joon Kim, Kwang-Hyub Han, Young Dae Kim Source Type: research
Reply to: “Endothelial progenitor cell release is usually considered a beneficial effect: Problems in interpreting the acute effects of e-cigarette use”
Vascular injury has long been known to be the main cause for mobilization of endothelial progenitor cells (EPCs) [1 –3]. It has been proven that the strongest factor mobilizing EPCs is hypoxia in the vascular wall, causing the release of vascular endothelial growth factor 2 (VEGF-2) and stromal derived factor 1 (SDF-1) [1–3]. These two factors bind to receptors on EPCs, initiating mobilization and homing to t he site of lesion. Therefore, it is not surprising that in cases of obvious vascular damage, such as in myocardial infarction or stroke, EPCs are highly elevated [1–3].
Source: Atherosclerosis - January 19, 2017 Category: Cardiology Authors: Lukasz Antoniewicz, Anna Kiessling, Fariborz Mobarrez, Magnus Lundb äck Tags: Correspondence Source Type: research
Clinical relevance of biomarkers for the identification of patients with carotid atherosclerotic plaque: Potential role and limitations of cysteine protease legumain
Asymptomatic carotid artery stenoses are common in the elderly population [1]. The presence of a carotid plaque is a major risk factor for the occurrence of athero-embolic stroke [2], and is associated with a higher incidence of silent brain ischemia [3]. Biomarkers, in addition to traditional cardiovascular risk factors, can help identify patients at risk of bearing an asymptomatic carotid artery stenosis, leading to the implementation of effective ultrasonographic screening programs [4]. In particular, inflammatory regulators, such as interleukin-6 and tumor necrosis factor- α, were shown to predict the presence and cha...
Source: Atherosclerosis - January 16, 2017 Category: Cardiology Authors: Enrico Ammirati, Federica Fogacci Tags: Editorial Source Type: research
Is there a role for coronary artery calcification scoring in primary prevention of cerebrovascular disease?
Cerebrovascular disease (CVA) is one of the most prevalent causes of death and disability in the United States, and its primary prevention is crucial. For the primary prevention of CVA, it is commonly recommended that all adults should initially undergo an office-based traditional risk assessment using established predictive models, such as the Framingham Stroke Profile Score or the atherosclerotic cardiovascular disease (ASCVD) risk calculator from the American College of Cardiology/American Heart Association (ACC/AHA).
Source: Atherosclerosis - January 13, 2017 Category: Cardiology Authors: Kazuhiro Osawa, Rine Nakanishi, Matthew Budoff Tags: Review article Source Type: research
CD98 promotes vascular smooth muscle cell accumulation in atherosclerosis to confer plaque stability
Atherosclerosis is a chronic progressive inflammatory disease and the leading cause of death worldwide. The major clinical consequences of atherosclerosis, such as myocardial infarction and stroke, are usually associated with a disruption of instable atherosclerotic plaques leading to thrombosis and embolism. Such instable plaques prone to rupture are characterized by a thin fibrous cap, high density of macrophages, and a large necrotic core. Conversely, a thick layer of VSMCs covering the necrotic core is considered to reduce the risk of plaque rupture.
Source: Atherosclerosis - November 25, 2016 Category: Cardiology Authors: Alma Zernecke Tags: Editorial Source Type: research
Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: Relationship with TOAST subtype
Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification.
Source: Atherosclerosis - October 27, 2016 Category: Cardiology Authors: Antonino Tuttolomondo, Alessandra Casuccio, Vittoriano Della Corte, Carlo Maida, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Irene Simonetta, Valentina Arnao, Antonio Pinto Source Type: research
Corrigendum to “Arterial stiffness indexes in acute ischemic stroke: Relationship with stroke subtype” Atherosclerosis 211 (2010) 187–194
The authors regret a mistake in the Results section. The sentence “… PWV values in lacunar subjects (112 ± 5.5%; 11.98 ± 2.445 m/s) were significantly higher compared to values observed in LAAS (108 ± 3.5%; 5.80 ± 0.445 m/s), CEI (104 ± 3.5%; 10.40 ± 2.445 m/s) and ODE (105 ± 3.5%; 11.48 ± 1.345 m/s) subtypes” is corrected as fol lows “… PWV values in lacunar subjects (112 ± 5.5%; 12.04 ± 1.54 m/s) were significantly higher compared to values observed in LAAS (108 ± 3.5%; 11.98 ± 2.445 m/s) CEI (104 ± 3.5%; 10.40 ± 2.445 m/s) and ODE (105 ± 3.5%; 11.48 ± 1.3...
Source: Atherosclerosis - October 22, 2016 Category: Cardiology Authors: Antonino Tuttolomondo, Riccardo Di Sciacca, Domenico Di Raimondo, Antonia Serio, Gisella D'Aguanno, Antonio Pinto, Giuseppe Licata Tags: Corrigendum Source Type: research
Determinants of carotid atherosclerotic plaque burden in a stroke-free population
In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis.
Source: Atherosclerosis - October 13, 2016 Category: Cardiology Authors: Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H. Franco, Wiro J. Niessen, Stefan Klein, Meike W. Vernooij, Aad Van der Lugt, Jolanda J. Wentzel Source Type: research
Association between infectious burden, socioeconomic status, and ischemic stroke
Infectious diseases contribute to stroke risk, and are associated with socioeconomic status (SES). We tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (IS) and partly explains the association between low SES and ischemic stroke.
Source: Atherosclerosis - October 4, 2016 Category: Cardiology Authors: Frederick Palm, Pirkko J. Pussinen, Annette Aigner, Heiko Becher, Florian Buggle, Matthias F. Bauer, Caspar Grond-Ginsbach, Anton Safer, Christian Urbanek, Armin J. Grau Source Type: research
Atrial fibrillation is associated with an increased risk of myocardial infarction: Insights from a meta-analysis
The presence of atrial fibrillation (AF) markedly increases the risk of stroke and mortality in patients. Whether AF is a risk factor for myocardial infarction (MI) is discrepant from current studies. The aim of this meta-analysis was to ascertain the association of AF with incident MI.
Source: Atherosclerosis - September 9, 2016 Category: Cardiology Authors: Xue-Yuan Guo, Na Li, Xin Du, Rong Bai, Rong-Hui Yu, De-Yong Long, Ri-Bo Tang, Cai-Hua Sang, Chen-Xi Jiang, Man Ning, Song-Nan Li, Nian Liu, Jian-Zeng Dong, Chang-Sheng Ma Source Type: research
Old challenges and new opportunities in the clinical management of heterozygous familial hypercholesterolemia (HeFH): The promises of PCSK9 inhibitors
Heterozygous familial hypercholesterolemia (HeFH) is a common (early estimates suggested a prevalence of 1 in 500 individuals, but recent studies have indicated that it may be higher) genetic disorder characterized by markedly elevated plasma concentrations of low-density lipoprotein cholesterol (LDL-C). HeFH is associated with an elevated risk of premature coronary heart disease, stroke, and peripheral vascular disease. Despite the availability of reliable diagnostic criteria (high LDL-C levels, family history or premature CHD and hypercholesterolemia, cerebral/peripheral vascular disease, and the presence of tendon xanth...
Source: Atherosclerosis - August 31, 2016 Category: Cardiology Authors: Marcello Arca Tags: Review article Source Type: research
Association of BMI with total mortality and recurrent stroke among stroke patients: A meta-analysis of cohort studies
Studies of the association between obesity and total mortality and recurrent stroke events have shown contradictory results. Therefore, we aimed to conduct a meta-analysis to examine the association of body mass index (BMI) with total mortality and recurrent stroke events among patients after stroke onset.
Source: Atherosclerosis - August 27, 2016 Category: Cardiology Authors: Keyong Huang, Fangchao Liu, Xikun Han, Chen Huang, Jianfeng Huang, Dongfeng Gu, Xueli Yang Source Type: research
Dysfunctional HDL in acute stroke
HDL-cholesterol concentration is a reliable negative risk factor for acute cerebral infarction (ACI). Beyond quantitative aspects, our aim was to determine whether lipoprotein profiles and HDL functionality were altered at the acute phase of ischemic stroke.
Source: Atherosclerosis - August 24, 2016 Category: Cardiology Authors: Guadalupe Ortiz-Munoz, David Couret, Bertrand Lapergue, Eric Bruckert, Elena Meseguer, Pierre Amarenco, Olivier Meilhac Source Type: research
Prognostic value of urine dipstick proteinuria on mortality after acute ischemic stroke
This study was aimed at investigating the prognostic value of proteinuria measured by urine dipstick in patients with acute ischemic stroke.
Source: Atherosclerosis - August 24, 2016 Category: Cardiology Authors: Jinkwon Kim, Tae-Jin Song, Dongbeom Song, Joonsang Yoo, Jang-Hyun Baek, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo Source Type: research
