CD98 promotes vascular smooth muscle cell accumulation in atherosclerosis to confer plaque stability

Atherosclerosis is a chronic progressive inflammatory disease and the leading cause of death worldwide. The major clinical consequences of atherosclerosis, such as myocardial infarction and stroke, are usually associated with a disruption of instable atherosclerotic plaques leading to thrombosis and embolism. Such instable plaques prone to rupture are characterized by a thin fibrous cap, high density of macrophages, and a large necrotic core. Conversely, a thick layer of VSMCs covering the necrotic core is considered to reduce the risk of plaque rupture.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Editorial Source Type: research