GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by hyperglycaemia and insulin resistance. Diabetes mellitus is well-established as a major risk factor for the development of cardiovascular disease (CVD). A collaborative meta-analysis of 102 prospective studies revealed that people with diabetes are exposed to two-fold excess risk for coronary heart disease and stroke after adjustment for lipid profiles and inflammatory markers [1]. Moreover, prevention of cardiovascular complications is regularly integrated in the regime of medical care in diabetic patients, as these patients have a similar risk level of myocardial infarction (MI) as the nondiabetic patients with previous MI [2].
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Editorial Source Type: research