A heritable netrin-1 mutation increases atherogenic immune responses

Atherosclerosis and its major clinical manifestations – myocardial infarction, ischemic stroke and peripheral artery disease – remain a leading cause of death worldwide [1]. The onset of atherosclerosis is driven by the accumulation and expansion of macrophages in the artery wall in response to lipid deposition. Subsequently, the macrophage's failu re to resolve the inflammation and to exit the plaque are key processes in the progression of atherosclerosis [2]. Understanding the underlying causes and pathological mechanisms of this chronic, low grade inflammation that sustains plaque progression has been a major focus of the field in the last decade [3].
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Editorial Source Type: research