Loss of function and missense variants in CCR2 and protection against atherosclerotic disease

Background and Aims: MCP-1 governs monocyte recruitment to atherosclerotic lesions. Coherent evidence from genetic analyses and large-scale epidemiological studies supports an association between circulating MCP-1 levels and risk of coronary artery disease and atherosclerotic stroke. Still, it remains unknown if pharmacologically targeting CCR2, the cognate receptor of MCP1, would offer protection against cardiovascular disease.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research