Biliverdin reductase B is a plasma biomarker for intraplaque hemorrhage and a predictor of ischemic stroke in symptomatic carotid stenosis

Background and Aims: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with plaque IPH. We explored the biomarker potential of plasma BLVRB through 1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI) and with recurrent ischemic stroke; and 2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.

Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Chemaly, D. Marlevi, M.-J. Iglesias, M. Lengquist, M. Kronqvist, D. Bos, D.H.K. Van Dam-Nolen, A. Van Der Kolk, J. Hendrikse, M. Kassem, L. Matic, J. Odeberg, M.R. De Vries, M.E. Kooi, U. Hedin Source Type: research