Therapeutic targeting of the LncRNA IMSET suppresses inflammation and atherosclerotic plaque progression

Background and Aims: Perpetual monocyte/macrophage recruitment and subsequent foam cell formation characterises advanced atherosclerotic plaques, especially lesions precipitating myocardial infarction and stroke. Recent advances have illuminated macrophage diversity within atherosclerotic plaques, with select populations attributed a deleterious role. Accordingly, novel targets within specific macrophage subsets may yield therapeutic potential.

Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: K. Di Gregoli, A. Bond, S. Smith, S. George, J. Johnson Source Type: research