Activation of protease-activated receptors in patients with new onset of atrial fibrillation contributes to systemic atherosclerotic risk

Aim: Atrial fibrillation (AF) remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world. A complex array of pathophysiological changes including fibrosis and inflammation increasing the propensity of the atria to develop or maintain AF. At the same time, these alterations are involved in the occurrence of the systemic hypercoagulable state in which protease-activated receptors (PARs) 1 and 2 are discussed to be mediators. We wanted to evaluate the pathomechanistic link between inflammation, hypercoagulability and the atherosclerotic risk in the context of PAR1 and PAR2 activation.

Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Julian Friebel, Marco Witkowski, Termeh Tabaraie, Max Wegner, Evelyn R üdiger, Daniel Steffens, Oskar Galuszka, Mario Kasner, Ulf Landmesser, Ursula Rauch-Kröhnert Source Type: research