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Total 1988 results found since Jan 2013.

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke
Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke.
Source: Frontiers in Neurology - June 9, 2020 Category: Neurology Source Type: research

An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
Conclusion: Overweight/obese patients with ischemic stroke have better survival than patients with low/normal weight. The association of BMI and stroke outcome is not changed by TYG index.
Source: Frontiers in Neurology - April 22, 2021 Category: Neurology Source Type: research

Association of glucose-lowering drugs with incident stroke and transient ischaemic attacks in primary care patients with type 2 diabetes: disease analyzer database
ConclusionsTreatment with SGLT2 inhibitors or GLP-1 receptor agonists might reduce non-fatal stroke/TIA in persons with newly diagnosed type 2 diabetes.
Source: Acta Diabetologica - August 6, 2022 Category: Endocrinology Source Type: research

Triglyceride-glucose index and the incidence of stroke: A meta-analysis of cohort studies
ConclusionA higher TyG index may be independently associated with a higher risk of stroke in individuals without stroke at baseline. The aforementioned findings need to be verified by a large-scale prospective cohort study to further clarify the underlying pathophysiological mechanism between the TyG index and stroke.
Source: Frontiers in Neurology - January 4, 2023 Category: Neurology Source Type: research

Elevated stress hyperglycemia and the presence of intracranial artery stenosis increase the risk of recurrent stroke
ConclusionsSHR represents a better biomarker to predict the risk of stroke recurrence in patients with ICAS than FPG and HbA1c regardless of previous diabetes mellitus.Trial registrationhttps://www.chictr.org.cn/showproj.aspx?proj=125817; Identifier, [ChiCTR2100046958].
Source: Frontiers in Endocrinology - January 9, 2023 Category: Endocrinology Source Type: research

Triglyceride-glucose index and the incidence of stroke: A meta-analysis of cohort studies
CONCLUSION: A higher TyG index may be independently associated with a higher risk of stroke in individuals without stroke at baseline. The aforementioned findings need to be verified by a large-scale prospective cohort study to further clarify the underlying pathophysiological mechanism between the TyG index and stroke.PMID:36686534 | PMC:PMC9845890 | DOI:10.3389/fneur.2022.1033385
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Canlin Liao Haixiong Xu Tao Jin Ke Xu Zhennan Xu Lingzhen Zhu Mingfa Liu Source Type: research

Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension
CONCLUSION: TyG is a significant risk factor for sICAS in hypertensive patients, and there is a synergistic effect of sICAS and higher TyG on ischemic stroke recurrence.TRIAL REGISTRATION NUMBER: The study was registered on 16 August 2019 at https://www.chictr.org.cn/showprojen.aspx?proj=41160 (No. ChiCTR1900025214).PMID:37076850 | DOI:10.1186/s12933-023-01823-6
Source: Atherosclerosis - April 19, 2023 Category: Cardiology Authors: Yongle Wang Tingting Liu Yanan Li Kaili Zhang Haimei Fan Jing Ren Juan Li Yali Li Xinyi Li Xuemei Wu Junhui Wang Lixi Xue Xiaolei Gao Yuping Yan Gaimei Li Qingping Liu Wenhua Niu Wenxian Du Yuting Liu Xiaoyuan Niu Source Type: research

Triglyceride-glucose index predicts death in patients with stroke younger than 65
ConclusionElevated TGI independently predicts death at 3 months and 12 months in patients under 65 with ischemic stroke. Regulating TGI is expected to be an approach to enhance prognosis in young individuals affected by ischemic stroke.
Source: Frontiers in Neurology - August 3, 2023 Category: Neurology Source Type: research

The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes
Conclusions: These results suggest that eNOS activation is required for the neuroprotection of insulin against ischemic stroke in patients with diabetes.Clinical Relevance: Our findings indicate that the impact of insulin in patients with diabetes with acute ischemic stroke is concurrently dependent on both endothelial nitric oxide synthase (eNOS) signaling and antihyperglycemic effects. When eNOS dysfunction (eg, vascular endothelial dysfunction) is developed in patients with diabetes, the beneficial effect of insulin might be diminished in acute ischemic stroke in spite of its preserved antihyperglycemic effect. For diab...
Source: Journal of Vascular Surgery - May 9, 2013 Category: Surgery Authors: Shiang-Suo Huang, Yi-Jhu Lu, Jiung-Pang Huang, Yang-Tzu Wu, Yuan-Ji Day, Li-Man Hung Tags: Basic research studies Source Type: research

Insulin for glycaemic control in acute ischaemic stroke.
CONCLUSIONS: After updating the results of our previous review, we found that the administration of intravenous insulin with the objective of maintaining serum glucose within a specific range in the first hours of acute ischaemic stroke does not provide benefit in terms of functional outcome, death, or improvement in final neurological deficit and significantly increased the number of hypoglycaemic episodes. Specifically, those people whose glucose levels were maintained within a tighter range with intravenous insulin experienced a greater risk of symptomatic and asymptomatic hypoglycaemia than those people in the control ...
Source: Cochrane Database of Systematic Reviews - January 23, 2014 Category: Journals (General) Authors: Bellolio MF, Gilmore RM, Ganti L Tags: Cochrane Database Syst Rev Source Type: research

GLP-1R activation for the treatment of stroke: Updating and future perspectives
Abstract Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension, atherosclerosis, obesity and diabetes all dramatically increase the risk of stroke. While preventive strategies based on lifestyle changes and risk factor management can delay or decrease the likelihood of having a stroke, post stroke pharmacological strategies aimed at minimizing stroke-induced brain damage are highly needed. Unfortunately, several candidate drugs that have shown significant precl...
Source: Reviews in Endocrine and Metabolic Disorders - September 1, 2014 Category: Endocrinology Source Type: research

Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial
Publication date: December 2014 Source:American Heart Journal, Volume 168, Issue 6 Author(s): Catherine M. Viscoli , Lawrence M. Brass , Antonio Carolei , Robin Conwit , Gary A. Ford , Karen L. Furie , Mark Gorman , Peter D. Guarino , Silvio E. Inzucchi , Anne M. Lovejoy , Mark W. Parsons , Peter N. Peduzzi , Peter A. Ringleb , Gregory G. Schwartz , J. David Spence , David Tanne , Lawrence H. Young , Walter N. Kernan Background Recurrent vascular events remain a major source of morbidity and mortality after stroke or transient ischemic attack (TIA). The IRIS Trial is evaluating an approach to secondary prevention based o...
Source: American Heart Journal - November 25, 2014 Category: Cardiology Source Type: research

Risk of Stroke in Chronic Heart Failure Patients without Atrial Fibrillation: Analysis of the CORONA and GISSI-HF Trials.
CONCLUSIONS: -A small number of demographic and clinical variables identified a subset of HF patients without AF at high risk of stroke. PMID: 25810334 [PubMed - as supplied by publisher]
Source: Circulation - March 25, 2015 Category: Cardiology Authors: Abdul-Rahim AH, Perez AC, Fulton RL, Jhund PS, Latini R, Tognoni G, Wikstrand J, Kjekshus J, Lip GY, Maggioni AP, Tavazzi L, Lees KR, McMurray JJ, Investigators of the Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) and GISSI-Heart F Tags: Circulation Source Type: research

Epigenetic changes in the methylation patterns of KCNQ1 and WT1 after a weight loss intervention program in obese stroke patients.
The objective of this research was to investigate, in obese patients suffering a previous stroke, the effects of a nutritional program on anthropometric and biochemical variables, and on the methylation patterns of two stroke-related genes (KCNQ1: potassium channel, voltage gated KQT-like subfamily Q, member 1; and WT1: Wilms tumor 1). Twenty-two ischemic stroke patients were compared with a control group composed of eighteen obese subjects with similar age and body mass index ranges. Both groups followed a 20-week nutritional program based on an energy-restricted balanced diet with high adherence to the Mediterranean diet...
Source: Current Neurovascular Research - July 31, 2015 Category: Neurology Authors: Abete I, Gomez-Uriz AM, Mansego ML, De Arce A, Goyenechea E, Blazquez V, Martinez-Zabaleta MT, Gonzalez-Muniesa P, De Munain AL, Martinez JA, Campion J, Milagro FI Tags: Curr Neurovasc Res Source Type: research