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Drug: Insulin

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Total 1988 results found since Jan 2013.

2-1-2 stroke microsurgical thrombectomy technique as a tertiary/salvage treatment option
CONCLUSIONS: 2-1-2 MST technique can be rapidly and efficaciously performed in a systemized manner offering a tertiary or salvage technique for acute stroke treatment. Specific microsurgical training is mandatory to accomplish this treatment and larger studies are necessary to confirm our hypothesis.PMID:35147401 | DOI:10.23736/S0390-5616.21.05480-1
Source: Journal of Neurosurgical Sciences - February 11, 2022 Category: Neurosurgery Authors: Marcelo M Oliveira Leonardo Avellar Jose A Malheiros Carlos E Ferrarez Geraldo M Lima Pollyana H Costa Source Type: research

Randomization to Treadmill Training Improves Physical and Metabolic Health in Association with Declines in Oxidative Stress in Stroke
CONCLUSIONS: Six months of TM tends to be associated with increased functional capacity and reduced oxidative stress in chronic stroke survivors. Our findings identify potentially modifiable systemic markers of inflammation and oxidative stress important to stroke rehabilitation and provide potential targets for novel therapeutics in future studies.PMID:35839921 | DOI:10.1016/j.apmr.2022.06.011
Source: Health Physics - July 15, 2022 Category: Physics Authors: Monica C Serra Charlene E Hafer-Macko Ronna Robbins Jason C O'Connor Alice S Ryan Source Type: research

Exosome-transported lncRNA H19 regulates insulin-like growth factor-1 via the H19/let-7a/insulin-like growth factor-1 receptor axis in ischemic stroke
This study provides the first evidence for the transportation of lncRNA H19 by exosomes and the relationship between lncRNA H19 and insulin-like growth factor-1.PMID:36453417 | DOI:10.4103/1673-5374.357901
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Jue Wang Bin Cao Yan Gao Yu-Hua Chen Juan Feng Source Type: research

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome: a case report from Nepal
Ann Med Surg (Lond). 2023 May 3;85(6):3026-3030. doi: 10.1097/MS9.0000000000000712. eCollection 2023 Jun.ABSTRACTMitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS) is a rare neurodegenerative inherited disorder that is characterized by stroke-like episodes, seizures, endocrine, and multiple system involvement. It is important to consider it as a differential diagnosis in a young patient with stroke-like episodes as it is progressive and has multiple complications.CASE PRESENTATION: A 28-year-old male presented with slurring of speech and drowsiness for 7 h. He was a diagnosed case of type 2 ...
Source: Annals of Medicine - June 26, 2023 Category: Internal Medicine Authors: Ram C Subedi Raju Paudel Sharma Paudel Lekhjung Thapa Subash Phuyal Naresh Kharbuja Ayush Adhikari Source Type: research

Dietary Fiber Intake and Risk of Stroke
Abstract Prospective studies show that a high intake of plant-derived foods, including fruits, vegetables, whole grains, and nuts, is associated with reduced risk of stroke. Among the many compounds present in these foods, dietary fiber may be an important mediator of the beneficial effects. Meta-analyses of prospective studies have reported an inverse association between intake of dietary fiber and risk of stroke. Findings from meta-analyses of randomized controlled trials show that fiber supplementation has a weak to modest beneficial effect on blood pressure as well as on total and low-density lipoprotein chol...
Source: Current Nutrition Reports - June 1, 2014 Category: Nutrition Source Type: research

A positive association between stroke risk and sarcopenia in men aged ≥ 50 years, but not women: Results from the Korean National Health and Nutrition Examination Survey 2008–2010
Conclusions men aged ≥50 years with sarcopenia showed elevated prevalence of CVDs, especially stroke, in a representative sample of the general South Korean population.
Source: The Journal of Nutrition, Health and Aging - October 10, 2014 Category: Nutrition Source Type: research

The Effects of Poststroke Aerobic Exercise on Neuroplasticity: A Systematic Review of Animal and Clinical Studies
Abstract Aerobic exercise may be a catalyst to promote neuroplasticity and recovery following stroke; however, the optimal methods to measure neuroplasticity and the effects of training parameters have not been fully elucidated. We conducted a systematic review and synthesis of clinical trials and studies in animal models to determine (1) the extent to which aerobic exercise influences poststroke markers of neuroplasticity, (2) the optimal parameters of exercise required to induce beneficial effects, and (3) consistent outcomes in animal models that could help inform the design of future trials. Synthesized findi...
Source: Translational Stroke Research - January 23, 2015 Category: Neurology Source Type: research

IRIS: Diabetes Drug Reduces Recurrent Stroke, MIIRIS: Diabetes Drug Reduces Recurrent Stroke, MI
A randomized trial shows that in patients with insulin resistance but no diabetes and a history of recent stroke or TIA, pioglitazone reduced recurrent stroke and myocardial infarction vs placebo. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - February 17, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Cerebrovascular disease: Pioglitazone reduces risk of stroke or MI
Nature Reviews Cardiology 13, 182 (2016). doi:10.1038/nrcardio.2016.34 Author: Karina Huynh Insulin resistance is present in >50% of patients without diabetes who have had an ischaemic stroke or a transient ischaemic attack (TIA). The IRIS trial investigators hypothesized that pioglitazone, an insulin-sensitizing agent, could reduce rates of stroke and myocardial infarction (MI) after ischaemic stroke or
Source: Nature Reviews Cardiology - March 3, 2016 Category: Cardiology Authors: Karina Huynh Tags: Research Highlight Source Type: research

Which Patients With Ischemic Stroke and Insulin Resistance May Benefit From Pioglitazone?
The Insulin Resistance Intervention After Stroke (IRIS) trial has reported that treating insulin resistance with the peroxisome proliferator –activated receptor γ agonist pioglitazone hydrochloride reduced recurrent stroke or myocardial infarction (MI) by about one-fourth compared with placebo (pioglitazone, 9.0% vs placebo, 11.8%; hazard ratio [HR], 0.76; 95% CI, 0.62-0.93) in 3876 patients with recent (<6 months) ischemic stroke or transient ischemic attack and insulin resistance but without diabetes, heart failure, or bladder cancer. Pioglitazone was also associated with less incident diabetes vs placebo (3.8% vs ...
Source: JAMA Neurology - September 18, 2017 Category: Neurology Source Type: research

Targeting Pioglitazone Therapy After Stroke or Transient Ischemic Attack
This secondary analysis of the Insulin Resistance Intervention After Stroke trial estimates the relative and absolute effectiveness of pioglitazone after ischemic stroke or transient ischemic attack in subgroups of patients defined by pretreatment risk for stroke or myocardial infarction.
Source: JAMA Neurology - September 18, 2017 Category: Neurology Source Type: research

IRIS: Best Candidates for Pioglitazone After Stroke IRIS: Best Candidates for Pioglitazone After Stroke
Stroke patients with insulin resistance who are at greatest risk for repeat stroke derive the greatest benefit from pioglitazone treatment.Medscape Medical News
Source: Medscape Today Headlines - September 26, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news