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Drug: Insulin

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Total 1988 results found since Jan 2013.

α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke
AbstractVagus nerve stimulation through the action of acetylcholine can modulate inflammatory responses and metabolism. α7 Nicotinic Acetylcholine Receptor (α7nAChR) is a key component in the biological functions of acetylcholine. To further explore the health benefits of vagus nerve stimulation, this study aimed to investigate whether α7nAChR agonists offer beneficial effects against poststroke inflammatory and m etabolic changes and to identify the underlying mechanisms in a rat model of stroke established by permanent cerebral ischemia. We found evidence showing that pretreatment with α7nAChR agonist, GTS-21, improv...
Source: Metabolic Brain Disease - January 20, 2023 Category: Neurology Source Type: research

Association Between Serum Vitamin D Levels and Physical Outcomes of Patients Who Underwent Rehabilitation Following Ischemic Stroke
CONCLUSIONS Lower serum vitamin D levels and more advanced age may be associated with worse functional outcomes in first-ever ischemic stroke patients.PMID:37248685 | DOI:10.12659/MSM.940115
Source: Medical Science Monitor - May 30, 2023 Category: Research Authors: Wojciech Borowicz Kuba Ptaszkowski Lucyna Ptaszkowska Joanna Rosi ńczuk Eugenia Murawska-Cia łowicz Source Type: research

Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke
Myocardial injury post-stroke is a common sequela of acute stroke. Triglyceride-glucose index (TyG index), a valuable surrogate indicator of insulin resistance, has been suggested to be closely related to card...
Source: BMC Geriatrics - June 8, 2023 Category: Geriatrics Authors: Mu Niu, Zhikang Zhou, Long Wang, Jian Yang, Miao Sun, Xin Lv and Faqiang Zhang Tags: Research Source Type: research

Stroke neuroprotection: Estrogen and IGF‐1 interactions and the role of microglia
This article is protected by copyright. All rights reserved.
Source: Journal of Neuroendocrinology - June 14, 2013 Category: Endocrinology Authors: Farida Sohrabji, Madison Williams Tags: Review Article Source Type: research

Telmisartan Promotes Potential Glucose Homeostasis in Stroke-Resistant Spontaneously Hypertensive Rats via Peroxisome Proliferator-Activated Receptor γ Activation.
Abstract An angiotensin 2 type 1 receptor blocker (ARB) telmisartan possesses not only an anti-hypertensive effect but also an anti-metabolic syndrome effect due to peroxisome proliferator-activated receptor γ (PPAR-γ) activation. In the present study, we examined the effects of telmisartan on the angiotensin 2 type 1 receptor (AT1R), PPAR-γ, and insulin receptor (IR) in stroke-resistant spontaneously hypertensive rats (SHR-SR), comparing them with Wistar rats. Three-months-old SHR-SR rats were divided into three treatment groups, i.e., vehicle (SHR/Ve), low-dose telmisartan (0.3 mg/kg/day, SHR/Low), and high-d...
Source: Current Neurovascular Research - January 4, 2015 Category: Neurology Authors: Omote Y, Deguchi K, Kurata T, Yamashita T, Sato K, Hishikawa N, Abe K Tags: Curr Neurovasc Res Source Type: research

Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction.
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats.
In conclusion, our data suggest that increased expression of hepatic antioxidative genes and modulation of Nrf2 may play a role in the regulation of metabolic diseases in SHRSP consuming a FBEP diet. PMID: 26072687 [PubMed - as supplied by publisher]
Source: Bioscience, Biotechnology, and Biochemistry - June 15, 2015 Category: Biochemistry Authors: Ardiansyah, Shirakawa H, Giriwono PE, Oguchi K, Ueda K, Hokazono H, Hiwatashi K, Takahashi S, Sato S, Komai M Tags: Biosci Biotechnol Biochem Source Type: research

Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke.
Authors: Jotic A, Milicic T, Covickovic Sternic N, Kostic VS, Lalic K, Jeremic V, Mijajlovic M, Lukic L, Rajkovic N, Civcic M, Macesic M, Seferovic JP, Stanarcic J, Aleksic S, Lalic NM Abstract We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.0...
Source: International Journal of Endocrinology - June 21, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Diabetes drug may prevent heart attack, recurring stroke
Stephen FellerNEW HAVEN, Conn., Feb. 17 (UPI) -- The diabetes drug Actos was shown to lower the risk of recurring stroke and heart attack in a large clinical trial of insulin-resistant stroke patients.
Source: Health News - UPI.com - February 17, 2016 Category: Consumer Health News Source Type: news

Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes.
Abstract Approximately 80% of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) carry the A3243G mutation in the mitochondrial tRNALeu (UUR) gene. Conversely, this mutation has also been identified as one of the most prevalent genetic abnormalities in patients with diabetes mellitus. Mitochondrial diabetes mellitus complicated with MELAS is relatively common, and 12.5% of patients with the A3243G mutation develop MELAS after being diagnosed with diabetes mellitus. However, the clinical impact of diabetes mellitus in MELAS patients remains unclear. Therefore, we...
Source: The Tohoku Journal of Experimental Medicine - April 13, 2016 Category: Research Authors: Murakami T, Shinoto Y, Yonemitsu S, Muro S, Oki S, Koga Y, Goto Y, Kaneda D Tags: Tohoku J Exp Med Source Type: research

Pioglitazone After Ischemic Stroke or Transient Ischemic Attack
In patients without diabetes but who have insulin resistance along with a recent history of ischemic stroke or TIA, the risk of stroke or myocardial infarction was lower among those patients who received pioglitazone than among those who received placebo.
Source: Journal of Vascular Surgery - June 24, 2016 Category: Surgery Authors: W.N. Kernan, C.M. Viscoli, K.L. Furie Tags: Abstract Source Type: research

Pioglitazone in patients with insulin resistance after ischemic stroke or transient ischemic attack: A comment on the IRIS trial
Pioglitazone, an antidiabetic drug, also exerts several cardiometabolic benefits including antioxidant, anti-inflammatory, antihypertensive, vasoprotective and hypolipidemic effects. These pioglitazone-related benefits have been observed in different patient populations such as those with prediabetes, non-alcoholic fatty liver disease and type 2 diabetes mellitus (T2DM). With regard to cardiovascular (CV) morbidity and mortality, there is conflicting evidence.Recently, the Insulin Resistance Intervention after Stroke (IRIS) trial reported a significant pioglitazone-induced decrease in CV morbidity in patients with insulin ...
Source: Journal of Diabetes and Its Complications - September 17, 2016 Category: Endocrinology Authors: Niki Katsiki, Dimitri P Mikhailidis Source Type: research

Verification of a Proteomic Biomarker Panel to Diagnose Minor Stroke and Transient Ischaemic Attack: Phase 1 of SpecTRA, a Large Scale Translational Study.
CONCLUSIONS: Our panel has the potential to assist ED physicians in distinguishing TIA from mimic patients. PMID: 29385837 [PubMed - as supplied by publisher]
Source: Biomarkers - February 3, 2018 Category: Research Tags: Biomarkers Source Type: research

Insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in Chinese subjects from ischemic stroke
Previous studies suggested that insulin resistance (IR) may be a significant causal risk factor for cardiovascular events and depression independent of other risk factors. In this prospective, we assess the value of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) at admission to predict post-stroke depression (PSD) later developed at 3 months follow-up.
Source: Journal of Affective Disorders - February 2, 2018 Category: Neurology Authors: Han-Cheng Qiu, Hui-Zhen Liu, Xuemei Li, Xianwei Zeng, Ji-Zong Zhao Tags: Research paper Source Type: research