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Drug: Insulin

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Total 1988 results found since Jan 2013.

Association between β‐cell function estimated by HOMA‐β and prognosis of nondiabetic patients with ischaemic stroke
ConclusionsOur study shows that lower HOMA‐β level is associated with poor outcomes at one year in nondiabetic patients with ischaemic stroke.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 1, 2017 Category: Neurology Authors: Mengyuan Zhou, Yuesong Pan, Jing Jing, Yongjun Wang, Xingquan Zhao, Liping Liu, Hao Li, Yilong Wang Tags: Original Article Source Type: research

Association between β‐cell function estimated by HOMA‐β and prognosis of non‐diabetic patients with ischaemic stroke
ConclusionsOur study shows that lower HOMA‐β level is associated with poor outcomes at 1 year in non‐diabetic patients with ischaemic stroke.
Source: European Journal of Neurology - January 15, 2018 Category: Neurology Authors: M. Zhou, Y. Pan, J. Jing, Y. Wang, X. Zhao, L. Liu, H. Li, Y. Wang Tags: Original Article Source Type: research

Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke.
DISCUSSION: Biomarkers have the potential to characterize an individual's potential for recovery from stroke. Neurotrophins such as insulin-like growth factor-1 and brain-derived neurotrophic factor are thought to be important in neurorehabilitation; however, the factors that modulate these biomarkers are not well understood. Resting brain-derived neurotrophic factor and percent change in brain-derived neurotrophic factor were related to physical and cognitive recovery in chronic stroke, albeit weakly. Insulin-like growth factor-1 was not an informative biomarker among chronic stroke patients. The novel finding that fluid ...
Source: Neurological Research - January 9, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke
ConclusionThis study strongly suggests that IR is probably an independent risk factor for END in non-diabetic patients with acute ischemic stroke.
Source: Neurological Sciences - January 13, 2020 Category: Neurology Source Type: research

Stroke Prevention: Little-Known and Neglected Aspects
Combining available therapies has the potential to reduce the risk of stroke by 80% or more. A comprehensive review of all aspects of stroke prevention would be very lengthy; in this narrative review, we focus on some aspects of stroke prevention that are little-known and/or neglected. These include the following: (1) implementation of a Mediterranean diet; (2) B vitamins to lower homocysteine; (3) coordinated approaches to smoking cessation; (4) intensive lipid-lowering therapy; (5) lipid lowering in the elderly; (6) physiologically individualized therapy for hypertension based on renin/aldosterone phenotyping; (7) avoidi...
Source: Cerebrovascular Diseases - May 27, 2021 Category: Neurology Source Type: research

Effect of SGLT2 Inhibitors on Risk of Stroke in Diabetes: A Meta-Analysis
Conclusions: In summary, this meta-analysis indicated that the use of SGLT2 inhibitors did not decrease the risk of stroke. And for some T2DM patients with high-risk factor of stroke, SGLT2 inhibitors therapy may be more suitable compared to some oGLD such as dipeptidyl peptidase-4 inhibitors. The results of this meta-analysis are necessary to be confirmed with further studies and clinical trials.Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 31, 2022 Category: Neurology Source Type: research

Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis
Conclusion Higher serum IGF-1 was significantly correlated with a lower risk of ischaemic stroke. In view of the high degree of heterogeneity, it may need more studies to confirm the prognostic value of serum IGF-1 levels in ischaemic stroke and explore the sources of heterogeneity.
Source: BMJ Open - June 15, 2022 Category: General Medicine Authors: Li, Y., Yang, W., Li, J., Zhang, Y., Zhang, L., Chen, S., He, L., Zhang, Y. Tags: Open access, Neurology Source Type: research

Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
The pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and promotes the development of atherosclerosis, both of which are major mechanisms of ischemic stroke. Additionally, insulin resistance negatively affects the prognosis of patients with ischemic stroke regardless of whether the patient has diabetes, but the mechanisms are not well studied. We explored the association between insulin resistance and the primary mechanisms of brai...
Source: Frontiers in Endocrinology - December 15, 2022 Category: Endocrinology Source Type: research

Adiponectin and incident coronary heart disease and stroke. A systematic review and meta‐analysis of prospective studies
In conclusion, plasma adiponectin is not related to the risk for incident CHD or stroke.
Source: Obesity Reviews - March 18, 2013 Category: Eating Disorders and Weight Management Authors: D. A. Kanhai, M. E. Kranendonk, C. S. P. M. Uiterwaal, Y. Graaf, L. J. Kappelle, F. L. J. Visseren Tags: Etiology and Pathophysiology/Obesity Comorbidity Source Type: research

High dietary fiber intake prevents stroke at a population level
Summary: Background & aims: This research was aimed at clarifying whether high dietary fiber intake has an impact on incidence and risk of stroke at a population level.Methods: In 1647 unselected subjects, dietary fiber intake (DFI) was detected in a 12-year population-based study, using other dietary variables, anagraphics, biometrics, blood pressure, heart rate, blood lipids, glucose, insulin, uricaemia, fibrinogenaemia, erytrosedimentation rate, diabetes, insulin resistance, smoking, pulmonary disease and left ventricular hypertrophy as covariables.Results: In adjusted Cox models, high DFI reduced the risk of stroke. In...
Source: Clinical Nutrition - January 7, 2013 Category: Nutrition Authors: Edoardo Casiglia, Valérie Tikhonoff, Sandro Caffi, Giovanni Boschetti, Carla Grasselli, Mario Saugo, Nunzia Giordano, Valentina Rapisarda, Paolo Spinella, Paolo Palatini Tags: Original Articles Source Type: research

Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats.
Abstract Diabetes worsens functional outcome and is associated with greater hemorrhagic transformation (HT) after ischemic stroke. We have shown that diabetic Goto-Kakizaki (GK) rats develop greater HT and neurological deficit despite smaller infarcts after transient middle cerebral artery occlusion (MCAO) with the suture model. However, the impact of 1) the duration of ischemia/reperfusion (I/R); 2) the method of ischemia; and 3) acute glycemic control on neurovascular injury and functional outcome in diabetic stroke remained unanswered. Wistar and GK rats were subjected to variable MCAO by suture or embolus occl...
Source: Brain Research - October 18, 2013 Category: Neurology Authors: Li W, Qu Z, Prakash R, Chung C, Ma H, Hoda MN, Fagan SC, Ergul A Tags: Brain Res Source Type: research

Increase of circulating miR-223 and insulin-like growth factor-1 is associated with the pathogenesis of acute ischemic stroke in patients
Background: The relationship between circulating microRNA-223 and pathogenesis of acute ischemic stroke is unknown. Here we investigated the roles and possible targets of circulating microRNA-223 in human ischemic stroke within the first 72 hours. Methods: Blood samples were collected from patients within 72 hours after cerebral ischemia (n = 79) and compared with healthy control samples (n = 75). The level of possible downstream factors of microRNA-223 including insulin-like growth factor-1, insulin-like growth factor-1 receptor and interleukin-6 was examined by ELISA assay. The relationship between the microRNA-223 level...
Source: BMC Neurology - April 8, 2014 Category: Neurology Authors: Yang WangYu ZhangJun HuangXiaoyan ChenXiang GuYongting WangLili ZengGuo-Yuan Yang Source Type: research

Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetics.
Abstract The risk of stroke is drastically increased in diabetic and pre-diabetic patients. The worldwide spread of obesity and insulin resistance increases the incidence of stroke. The direct effect of insulin resistance, as it pertains to stroke, on the central nervous system is not well understood. Since one of the physiological functions of the cellular prion protein (PrP(C)) is neuroprotection, we studied effects of brain insulin resistance on the expression of PrP(C) in fructose-fed rats as an animal model of prediabetes. Compared with control chow-fed animals, rats fed a high-fructose diet (FF), exhibited c...
Source: Biochemical and Biophysical Research communications - April 26, 2014 Category: Biochemistry Authors: Pham N, Khalaj S, Dhar A, Desai K, Taghibiglou C Tags: Biochem Biophys Res Commun Source Type: research