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Drug: Insulin

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Total 1988 results found since Jan 2013.

Is management of hyperglycaemia in acute phase stroke still a dilemma?
ConclusionBoth hypoglycaemia and hyperglycaemia may lead to further brain injury and clinical deterioration; that is the reason these conditions should be avoided after stroke. Yet, when correcting hyperglycaemia, great care should be taken not to switch the patient into hypoglycaemia, and subsequently aggressive insulin administration treatment should be avoided. Early identification and prompt management of hyperglycaemia, especially in acute ischaemic stroke, is recommended. Although the appropriate level of blood glucose during acute stroke is still debated, a reasonable approach is to keep the patient in a mildly hype...
Source: Journal of Endocrinological Investigation - November 20, 2016 Category: Endocrinology Source Type: research

Back to Basics: Adherence With Guidelines for Glucose and Temperature Control in an American Comprehensive Stroke Center Sample
Conclusion: Glucose and temperature control may be overlooked in this era of rapid stroke diagnosis and treatment. Acute stroke nurses are well positioned to assume leadership of glucose and temperature monitoring and treatment.
Source: Journal of Neuroscience Nursing - May 5, 2018 Category: Neuroscience Tags: Article Source Type: research

Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up
Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes - June 30, 2019 Category: Endocrinology Authors: Åberg, N. David Åberg, Daniel Lagging, Cecilia Holmegaard, Lukas Redfors, Petra Jood, Katarina Nilsson, Michael Åberg, Maria Blomstrand, Christian Svensson, Johan Jern, Christina Isgaard, J örgen Tags: Article Source Type: research

Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report
ConclusionsGrowth differentiation factor-15 can be used not only for the diagnosis of mitochondrial disease, but as an indicator of its acute exacerbation. A stroke-like episode of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes reflects a drastic derangement of multiple amino acids. The involvement of aspartic acid in the episodes should be explored in future studies.
Source: Journal of Medical Case Reports - October 20, 2019 Category: General Medicine Source Type: research

Insulin-treated versus noninsulin-treated diabetes and risk of ischemic stroke in patients with atrial fibrillation.
CONCLUSION: In patients with AF, DM increases the risk of ischemic stroke, regardless of treatment. PMID: 33130017 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - October 28, 2020 Category: Drugs & Pharmacology Authors: Jensen T, Olesen KKW, Caterina, Würtz M, Kristensen SD, Maeng M Tags: Vascul Pharmacol Source Type: research

Glycemic Control in Hospitalized Stroke Patients: A Review
AbstractPurpose of ReviewThe purpose of this review is to discuss clinical trials involving glycemic control in hospitalized stroke patients and to review oral medications used in glycemic control. GLP-1 agonists, which have some preliminary studies in ischemic stroke, will also be reviewed.Recent FindingsUntil recently, glycemic control targets in hospitalized stroke patients remained unclear. The SHINE (Stroke Hyperglycemia Insulin Network Effort) trial demonstrated no significant difference between aggressive versus standard of care glycemic control in the acute ischemic stroke patient.SummaryAlthough SHINE demonstrated...
Source: Current Diabetes Reports - December 1, 2021 Category: Endocrinology Source Type: research

Triglyceride-Glucose Index and Intravenous Thrombolysis Outcomes for Acute Ischemic Stroke: A Multicenter Prospective –Cohort Study
ConclusionThis study supports the strong association between the increased TyG index and increased unfavorable functional outcomes at 90 days in patients with acute ischemic stroke treated with IVT. These findings were found to be robust in patients with moderate and high stroke severity.
Source: Frontiers in Neurology - February 14, 2022 Category: Neurology Source Type: research

The effect of covariate adjustment for baseline severity in acute stroke clinical trials with responder analysis outcomes
Conclusions: Our results suggest that, under the given treatment effect scenarios, the decision whether or not to adjust for baseline severity when using a responder analysis outcome should be guided by the needs of the study, as type I error rates and power do not appear to vary largely between the methods. These findings are applicable to stroke trials which use the mRS for the primary outcome, but also provide a broader insight into the analysis of binary outcomes that are defined based on baseline prognostic variables.Trial registration: This research is part of the Stroke Hyperglycemia Insulin Network Effort (SHINE) t...
Source: Trials - April 11, 2013 Category: Journals (General) Authors: Kyra GarofoloSharon YeattsViswanathan RamakrishnanEdward JauchKaren JohnstonValerie Durkalski Source Type: research

Circulating Fetuin-A and Risk of Ischemic Stroke in Women Proteomics and Protein Markers
CONCLUSIONS: In this sample of women, fetuin-A was not significantly associated with risk of ischemic stroke. Further research is needed to explore this association.
Source: Clinical Chemistry - December 30, 2013 Category: Chemistry Authors: Jimenez, M. C., Sun, Q., Schurks, M., Hu, F. B., Manson, J. E., Rexrode, K. M. Tags: Proteomics and Protein Markers Source Type: research

Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats.
Abstract Patients who experience acute ischemic stroke may develop hyperglycemia, even in the absence of diabetes. In the current study we determined the effects of acute stroke on hepatic insulin signaling, tumor necrosis factor α (TNF-α) expression, endoplasmic reticulum (ER) stress, the activities of c-Jun N-terminal kinase (JNK), inhibitor κB kinase β (IKK-β), and nuclear factor-κB (NF-κB) pathways. Rats with cerebral ischemia developed higher blood glucose, and insulin levels, and insulin resistance index, as well as hepatic gluconeogenic enzyme expression compared to the sham-treated group. The hepati...
Source: Endocrinology - January 17, 2014 Category: Endocrinology Authors: Wang YY, Lin SY, Chuang YH, Sheu WH, Tung KC, Chen CJ Tags: Endocrinology Source Type: research

Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
DiscussionThe goal of this endpoint-blinded, phase III randomised controlled trial is to provide evidence to guide post-stroke physical fitness-based rehabilitation programmes, and to elucidate the mechanisms underlying this intervention.Trial registration: Registered in ClinicalTrials.gov with the Identifier NCT01953549.
Source: Trials - February 3, 2014 Category: Journals (General) Authors: Agnes FlöelCordula WernerUlrike GrittnerStefan HesseMichael JöbgesJanet KnaussMichael SeifertElisabeth Steinhagen-ThiessenMehmet GövercinChristian DohleWolfgang FischerRegina SchliederAlexander NaveAndreas MeiselMartin EbingerIan Wellwood Source Type: research

Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke
Conclusions. Improving aerobic fitness prior to stroke may be beneficial by increasing baseline IGF-1 levels. These results set the groundwork for future clinical trials to determine whether high IGF-1 and aerobic fitness are beneficial to stroke recovery by providing neuroprotection and improving function.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Mattlage, A. E., Rippee, M. A., Abraham, M. G., Sandt, J., Billinger, S. A. Tags: Original Research Articles Source Type: research

Insulin resistance in ischemic stroke
AbstractInsulin resistance often refers to a pathological condition in which cells fail to respond to the normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in the pathogenesis of ischemic stroke. Insulin resistance plays an important role in the pathogenesis of ischemic stroke via enhancing advanced changes of atherosclerosis. A variety of literature indicates that insulin resistance enhances platelet adhesion, activation and aggregation which are conducive to the occurrence of ischemic stroke. Insulin resistance also induces hemodynamic disturbances and contributes to the ons...
Source: Metabolic Brain Disease - June 21, 2017 Category: Neurology Source Type: research

Relation of Carotid Artery Plaque to Coronary Heart Disease and Stroke in Chinese Patients: Does Hyperglycemia Status Matter?
Conclusions The incident coronary heart disease and stroke events in patients with plaque were higher than those without plaque, and this difference was more pronounced for patients with hyperglycemia vs. those without hyperglycemia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - November 28, 2017 Category: Endocrinology Authors: Zhou, Huanhuan Wang, Xiaoyun Zhu, Junya Fish, Anne Kong, Weimin Li, Fan Liu, Lin Yuan, Xiaodan Gao, Xin Lou, Qingqing Tags: Article Source Type: research

European Academy of Neurology – European Stroke Organisation consensus statement and practical guidance for pre‐hospital management of stroke
This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 7, 2017 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G.A. Ford, A.C. Fonseca, G.J. Luijckx, J. Korv, N. P érez de la Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guidelines Source Type: research