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Drug: Insulin

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Total 1988 results found since Jan 2013.

Intravenous insulin treatment in acute stroke: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsThis meta‐analysis of randomized controlled trials does not support the use of intravenous insulin in hyperglycemic stroke patients to improve mortality or functional outcome. The risk of hypoglycemia is increased, however.
Source: International Journal of Stroke - December 30, 2013 Category: Neurology Authors: G. Ntaios, V. Papavasileiou, A. Bargiota, K. Makaritsis, P. Michel Tags: Systematic review Source Type: research

Growth Hormone Improves Cognitive Function After Experimental Stroke Basic Sciences
Conclusions—These findings provide compelling preclinical evidence for the usage of GH as a potential therapeutic tool in the recovery phase of patients after stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lin Kooi Ong, Wei Zhen Chow, Clifford TeBay, Murielle Kluge, Giovanni Pietrogrande, Katarzyna Zalewska, Patricia Crock, N. David Aberg, Andrew Bivard, Sarah J. Johnson, Frederick R. Walker, Michael Nilsson, Jorgen Isgaard Tags: Angiogenesis, Basic Science Research, Growth Factors/Cytokines, Cognitive Impairment, Neurogenesis Original Contributions Source Type: research

Microembolic Signals is Associated With Insulin Resistance Among Acute Ischemic Stroke Patients
This study aims to investigate the clinical correlation between intracranial MES and IR in AIS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Xuyou Zhou, Dongmei Zhang, Yong Zhou, Fang Wang, Xiangyang Zhu Source Type: research

Effect of Low-Intensity Ergometer Aerobic Training on Glucose Tolerance in Severely Impaired Nondiabetic Stroke Patients
Objective: To investigate whether low-intensity ergometer aerobic training has beneficial effect on glucose tolerance in nondiabetic patients with severely impaired stroke.Methods: Fifty-four severely impaired stroke survivors were recruited and randomly assigned to the experimental group and control group. They have no diabetes history with fasting plasma glucose less than 7 mmol/L. Both groups participated in a 6-week rehabilitation training program with low-intensity ergometer aerobic training added only in the experimental group 3 times per week. Primary outcome variables were fasting glucose, fasting insulin, 2-hour ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2013 Category: Neurology Authors: Zun Wang, Lei Wang, Hongjuan Fan, Xiao Lu, Tong Wang Tags: Original Articles Source Type: research

Neurovascular Protection by Telmisartan via Reducing Neuroinflammation in Stroke-Resistant Spontaneously Hypertensive Rat Brain after Ischemic Stroke
We examined the effects of telmisartan on neurovascular unit (N-acetylglucosamine oligomer [NAGO], collagen IV, and glial fibrillary acidic protein [GFAP]) and neuroinflammation (matrix metalloproteinase-9 [MMP-9] and inflammasome) in brain of stroke-resistant spontaneously hypertensive rat (SHR-SR). At 12 weeks of age, SHR-SR received transient middle cerebral artery occlusion (tMCAO) for 90 minutes and were divided into the following 3 groups, that is, vehicle group, low-dose telmisartan group (.3 mg/kg/d), and high-dose telmisartan group (3 mg/kg/d, postoral).
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2014 Category: Neurology Authors: Syoichiro Kono, Tomoko Kurata, Kota Sato, Yoshio Omote, Nozomi Hishikawa, Toru Yamashita, Kentaro Deguchi, Koji Abe Source Type: research

Tackling insulin resistance may reduce recurrence after stroke
Giving pioglitazone to stroke survivors with insulin resistance but no overt diabetes reduces their risk of having a recurrent vascular event, shows the randomised Insulin Resistance Intervention after Stroke trial.
Source: MedWire News - February 19, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice Basic Sciences
Conclusions— Treatment with exendin-4 could be a potentially useful therapeutic option for treatment of acute ischemic stroke with transient hyperglycemia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Kuroki, T., Tanaka, R., Shimada, Y., Yamashiro, K., Ueno, Y., Shimura, H., Urabe, T., Hattori, N. Tags: Treatment, Blood-Brain Barrier, Ischemic Stroke Basic Sciences Source Type: research

Long-term Amelioration of Telmisartan on Metabolic Syndrome-related Molecules in Stroke-resistant Spontaneously Hypertensive Rat after Transient Middle Cerebral Artery Occlusion
We examined the effects of telmisartan on metabolic syndrome-related molecules such as insulin receptor (IR), peroxisome proliferator-activated receptor gamma (PPAR-γ), and angiotensin 2 type 1 receptor (AT1R) in stroke-resistant spontaneously hypertensive rat (SHR-SR) after transient middle cerebral artery occlusion (tMCAO), by administering telmisartan at either 0 (vehicle), .3 mg/kg/day (low dose), or 3 mg/kg/day (high dose), postoperatively, from 3 months of age and performed immunohistologic analysis at 6, 12, and 18 months of age.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Kentaro Deguchi, Tomoko Kurata, Yusuke Fukui, Wentao Liu, Zhai Yun, Yoshio Omote, Kota Sato, Syoichiro Kono, Nozomi Hishikawa, Toru Yamashita, Koji Abe Source Type: research

A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
We sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2016 Category: Neurology Authors: Jin Xu, Catherine M. Viscoli, Gary A. Ford, Mark Gorman, Walter N. Kernan, IRIS Trial Investigators Source Type: research

Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke
Peroxisome proliferator-activated receptor (PPAR)- γ coactivator (PGC-1α) gene and Sirtuin-1 (SIRT-1) respond to physiological stimuli and regulate insulin resistance. Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vas cular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. Resistive training (RT) reduces hyperinsulinemia and improves insulin action in chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2016 Category: Neurology Authors: Alice S. Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M. Ivey Source Type: research

Insulin Resistance is Significantly Related with Worse Clinical Outcomes in Non-Diabetic Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
to investigate the relationship between insulin resistance (IR) and clinical outcomes in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Xiaoli Yang, Chen Li, Jing Li, Duanlu Hou, Yufan Luo, Shufan Zhang, Zhi Jin, Liwei Shen, Ping Zhong, Danhong Wu Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research