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Drug: Insulin

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Total 1988 results found since Jan 2013.

Changes in Serum Growth Factors in Stroke Rehabilitation Patients and Their Relation to Hemiparesis Improvement
Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic phase. The aim of this study was to examine the relationships between the serum levels of growth factors (vascular endothelial growth factor [VEGF], insulin-like growth factor-I [IGF-I], and hepatocyte growth factor [HGF]) and improvement in hemiparesis in stroke patients who received rehabilitation in a postacute rehabilitation hospital. Subjects were 32 stroke patients (cerebral ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2014 Category: Neurology Authors: Hideto Okazaki, Hidehiko Beppu, Kenmei Mizutani, Sayaka Okamoto, Shigeru Sonoda Tags: Original Articles Source Type: research

Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Stroke
This study aimed to estimate the association between post–glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Methods and ResultsData were derived from the ACROSS‐China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry. Patients with ischemic stroke without a history of diabetes mellitus were included. Two post–glucose load measures of insulin sensitivity, the insulin sensitivity indices ISI(composite) and the ISI0,120, were calculated. Outcomes included stroke recurrence, all‐cause death, and poor functional outcome at 12 months. A...
Source: JAHA:Journal of the American Heart Association - January 20, 2017 Category: Cardiology Authors: Pan, Y., Jing, J., Chen, W., Zheng, H., Jia, Q., Mi, D., Li, H., Zhao, X., Liu, L., Wang, C., Gaisano, H. Y., He, Y., Wang, Y., Tags: Ischemic Stroke Original Research Source Type: research

Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study Epidemiology
ConclusionsBoth HOMA‐IR and the McAuley index demonstrate strong associations with CHD but not stroke risk in blacks. The logHOMA‐IR and CHD association was present in men, but not in women.
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Effoe, V. S., Wagenknecht, L. E., Echouffo Tcheugui, J. B., Chen, H., Joseph, J. J., Kalyani, R. R., Bell, R. A., Wu, W.-C. H., Casanova, R., Bertoni, A. G. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Research Source Type: research

Post-stroke cognitive impairment and the risk of stroke recurrence and death in patients with insulin resistance
Post-stroke cognitive impairment (PSCI) is associated with etiology, severity, and functional outcome of stroke. The risks of recurrent stroke and death in patients with PSCI and insulin resistance (IR) is unknown. The goal of this study was to determine whether global and domain-specific cognitive impairment after stroke in patients with IR was associated with recurrent stroke and death.
Source: Journal of Stroke and Cerebrovascular Diseases - August 27, 2022 Category: Neurology Authors: Kat Schmidt, Melinda C. Power, Adam Ciarleglio, Zurab Nadareishvili, IRIS Study Group Source Type: research

Hyperglycemic control in acute ischemic stroke patients undergoing endovascular treatment: post hoc analysis of the Stroke Hyperglycemia Insulin Network Effort trial
Conclusion We did not identify any beneficial effect of intensive glucose reduction on rates of death or favorable outcomes at 90 days among acute ischemic stroke patients undergoing endovascular treatment.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Bains, N. K., Huang, W., French, B. R., Siddiq, F., Gomez, C. R., Qureshi, A. I. Tags: Ischemic stroke Source Type: research

Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia
ConclusionsOur results showed that acute stroke patients were: undermonitored and undertreated for fever and hyperglycemia; and underscreened for swallowing dysfunction and unnecessarily reassessed by a speech pathologist, indicating the need for urgent behavior change.
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Peta Drury, Christopher Levi, Elizabeth McInnes, Jennifer Hardy, Jeanette Ward, Jeremy M. Grimshaw, Catherine D' Este, Simeon Dale, Patrick McElduff, N Wah Cheung, Clare Quinn, Rhonda Griffiths, Malcolm Evans, Dominique Cadilhac, Sandy Middleton Tags: Research Source Type: research

Racial Differences in the Association of Insulin Resistance With Stroke Risk: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Clinical Sciences
Conclusions— These data support the growing evidence that insulin resistance may play a more important role in stroke risk among white than black individuals and suggest a potentially discordant relationship of insulin resistance on CI and ICH among whites.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Howard, G., Wagenknecht, L. E., Kernan, W. N., Cushman, M., Thacker, E. L., Judd, S. E., Howard, V. J., Kissela, B. M. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke
We present the theoretical background and pathophysiologic mechanisms, animal and human studies of intranasal insulin and IGF-1, and the safety and feasibility of intranasal route for medication administration to the CNS.
Source: Translational Stroke Research - June 4, 2015 Category: Neurology Source Type: research

Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes
High insulin-like growth factor-1 (IGF-1), measured once during acute stroke, is associated with greater survival rates and lower stroke severity. However, information is lacking regarding how IGF-1 availability, determined by IGF-1's ratio to insulin-like growth factor binding protein-3 (IGFBP-3), relates to recovery and how the response of IGF-1 during the first week of stroke relates to outcomes. The purpose of this study was to determine the following: (1) the relationship between percent change in IGF-1 and IGF-1 ratio during the first week of stroke and stroke outcomes; and (2) the difference in percent change in IGF...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2016 Category: Neurology Authors: Anna E. Mattlage, Michael A. Rippee, Janice Sandt, Sandra A. Billinger Source Type: research

Poor glycemic control and posterior circulation ischemic stroke
Conclusions Poor glycemic control may be associated with an increased risk of thrombotic infarction that occurs preferentially in the posterior circulation of the brain.
Source: Neurology Clinical Practice - April 7, 2019 Category: Neurology Authors: Kuroda, J., Matsuo, R., Yamaguchi, Y., Sato, N., Kamouchi, M., Hata, J., Wakisaka, Y., Ago, T., Kitazono, T., on behalf of the Fukuoka Stroke Registry Investigators Tags: Infarction Research Source Type: research

Resistive Training Improves Insulin Sensitivity after Stroke
This study determined the effects of unilateral resistive training (RT) of both the paretic and nonparetic legs on insulin sensitivity in stroke survivors.Methods: We studied 10 participants (mean age 65 ± 2 years; mean body mass index 27 ± 4 kg/m2) with hemiparetic gait after remote (>6 months) ischemic stroke. All subjects underwent 1-repetition maximum (1-RM) strength testing, 9 had an oral glucose tolerance test (OGTT), and 7 completed a 2-hour hyperglycemic clamp (with glucose elevation targeted at 98 mg/dL above baseline fasting level) before and after 12 weeks (3×/week) of progressive, high repetition, high-i...
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Frederick M. Ivey, Alice S. Ryan Tags: Original Articles Source Type: research

Higher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
Abstract Insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke. We investigated whether there is a relationship between insulin resistance and clinical findings and outcomes of acute ischemic stroke patients treated with intravenous thrombolysis. In our study, 180 acute ischemic stroke non-diabetic patients treated with intravenous recombinant tissue-type plasminogen activator (iv rt-PA) were evaluated for insulin resistance assessed by homeostasis model assessment insulin resistance (HOMA-IR). The threshold for HOMA-IR was determined as 2.7. Patients were grouped as HOMA-IR > 2...
Source: Translational Stroke Research - January 30, 2016 Category: Neurology Source Type: research

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease Clinical Sciences
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Longitudinal Relationship Between Intramuscular Fat in the Quadriceps and Gait Independence in Convalescent Stroke Patients
In stroke patients, secondary changes in the skeletal muscles, including decreased muscle mass and increased intramuscular fat, have been examined after stroke onset.1 These changes are greater on the paretic side than on the non-paretic side.2,3 In chronic stroke survivors, these secondary changes in skeletal muscles are associated with decreased muscle strength,4 gait independence,5 and aerobic exercise capacity.6 Furthermore, Ryan et al.2 have reported that increased intramuscular fat in stroke patients is associated with decreased insulin sensitivity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Taisei Ishimoto, Yusuke Taniguchi, Naoki Akazawa Source Type: research