HBV X mutation increases hepatocarcinogenesis risk
In patients with chronic hepatitis B virus infection, the presence of the X-gene T1753V mutation in the viral genome is associated with an elevated risk of progression to hepatocellular carcinoma, suggests research. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: HBV Source Type: news

Patient age, gender predict adult HBV vaccination nonresponse
A meta-analysis has identified predictive factors for a poor response to hepatitis B vaccination, with older adults, male patients, smokers and those with a high body mass index or illness at particular risk. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: HBV Source Type: news

HBeAg-negative status does not guarantee long-term inactivity
Hepatitis B e antigen-negative inactive carriers have an excellent prognosis, but some may deviate from this status within a relatively short period, meaning careful follow-up is needed, Japanese research shows. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: HBV Source Type: news

HF patients rarely tested for CAD
Tests for ischaemic coronary artery disease are badly underutilised in patients with new-onset heart failure, research shows. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Heart failure Source Type: news

Risk stratification tool aids vorapaxar treatment decisions after MI
Researchers have developed a risk stratification tool that could be used to identify patients with stable ischemic heart disease and prior myocardial infarction for whom intensive secondary preventative treatment outweighs the risk of severe bleeding. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Coronary heart disease Source Type: news

Regular exercise offsets sedentary mortality risks
Undertaking regular physical activity of at least moderate intensity may be key to long-term health, show the results of a meta-analysis published in The Lancet. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Stroke centre benefits dependent on access time
The survival gains from receiving treatment in a stroke centre are negated if patients have to travel too far to get there, US research shows. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

Simple risk score may aid TAVR candidate selection
A simple scoring system that takes comorbidity, frailty and disability into account can effectively stratify early and late mortality rates among extreme- and high-risk patients with aortic stenosis undergoing transcatheter aortic valve replacement, US researchers report. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Interventional cardiology Source Type: news

HMW multimers, haemostasis test predict TAVR outcomes
Researchers have identified two risk factors for postprocedural aortic regurgitation in patients undergoing transcatheter aortic-valve replacement. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Interventional cardiology Source Type: news

Apixaban 5 mg ‘appropriate’ in AF patients with one dose-reduction criterion
The benefits of apixaban 5 mg over warfarin are maintained in patients with atrial fibrillation who are of advanced age, have low body weight or elevated creatinine levels, analysis of ARISTOTLE data shows. (Source: MedWire News)
Source: MedWire News - July 29, 2016 Category: Consumer Health News Tags: Arrhythmia Source Type: news

Stroke centre benefits dependent on access time
The survival gains from receiving treatment in a stroke centre are negated if patients have to travel too far to get there, US research shows. (Source: MedWire News)
Source: MedWire News - July 28, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news

Simple risk score may aid TAVR candidate selection
A simple scoring system that takes comorbidity, frailty and disability into account can effectively stratify early and late mortality rates among extreme- and high-risk patients with aortic stenosis undergoing transcatheter aortic valve replacement, US researchers report. (Source: MedWire News)
Source: MedWire News - July 28, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news

Alteplase confers long-term survival benefit after stroke
Alteplase treatment in patients with acute ischaemic stroke is associated with a survival benefit among those who survive the acute phase, shows further analysis of IST-3. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

Neurodegeneration does not necessarily signal cognitive decline
Neurodegeneration on its own does not significantly increase an individual ’s risk of developing Alzheimer’s disease, indicate findings from a two-marker imaging study. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Alzheimer ' s disease Source Type: news

Real-world data confirm benefits of ticagrelor in ACS
A prospective study of more than 45,000 patients with acute coronary syndromes has shown that the risk of death or readmission with myocardial infarction or stroke is 15% lower with ticagrelor than with clopidogrel. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Acute coronary syndromes Source Type: news

Sub-diabetic glucose levels predict CVD
Researchers report a linear association between random plasma glucose levels and the risk of subsequent cardiovascular disease in people without diabetes. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Transcatheter mitral valve repair options expand
Researchers have successfully used a new transcatheter mitral valve repair device in 11 patients in a first-in-human trial. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Interventional cardiology Source Type: news

FFR influences lesion management in clinical practice
Lesion management strategy changes in nearly half of patients who undergo fractional flow reserve measurement in clinical practice, show the findings of the POST-IT trial. (Source: MedWire News)
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Coronary heart disease Source Type: news

LDL cholesterol variability has adverse neurocognitive effects
High variability in low-density-lipoprotein cholesterol levels between visits is associated with poor cognitive performance, researchers report. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Cardiometabolic Source Type: news

PCI for perioperative MI comes with high mortality risk
Percutaneous coronary intervention has a very high mortality rate when performed after perioperative myocardial infarction, with more than one in 10 patients not surviving beyond 30 days. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Interventional cardiology Source Type: news

‘Dramatic’ increase seen in CML life expectancy
Patients with chronic myeloid leukaemia can now expect to live almost as long as members of the general population, say researchers. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Chronic myeloid leukaemia Source Type: news

TKI therapy shows ‘excellent efficacy’ in Japanese CML population
A review of tyrosine kinase inhibitor therapy in Japanese patients with chronic myeloid leukaemia demonstrates high rates of treatment response and good outcomes but highlights the various issues associated with treatment discontinuation. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Chronic myeloid leukaemia Source Type: news

Long-term dasatinib supported in CML
Dasatinib has durable efficacy and manageable toxicity in the long-term treatment of patients with chronic-phase chronic myeloid leukaemia that is resistant or intolerant to imatinib, shows final analysis of the CA180-034 trial. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Chronic myeloid leukaemia Source Type: news

CAD consortium scores recommended over DF classification
Differences in US and European guidelines for evaluating the pretest probability of obstructive coronary artery disease result in significantly different risk estimations, which may influence further treatment for a significant proportion of individuals evaluated for chest pain, study findings indicate. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Coronary heart disease Source Type: news

Post-cardiac surgery mortality greatest after 75 years of age
The relationship between age and mortality after cardiac surgery is exponential rather than linear, with the greatest risk occurring in patients aged 75 years and older, research shows. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news

Engagement key to diabetes prevention success
A “relatively low-resource, pragmatic” intervention can prevent high-risk patients from progressing to Type 2 diabetes, but only if their engagement is sustained, shows analysis of the Let’s Prevent Diabetes trial. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Breast cancer risk reassurance for IVF-treated women
Women who receive in vitro fertilisation treatment do not have a higher risk of developing breast cancer in the long term versus those who receive non-IVF therapy and the general population, say Dutch researchers. (Source: MedWire News)
Source: MedWire News - July 22, 2016 Category: Consumer Health News Tags: Breast cancer Source Type: news

Renal impairment has ramifications for sulphonylurea use
A large study of patients in general practice shows that the risk of hypoglycaemia associated with sulphonylurea use is highest in patients with impaired renal function. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Antidiabetic classes broadly similar for cardiovascular mortality
A network meta-analysis published in JAMA finds no notable differences in cardiovascular mortality among patients give nine classes of antidiabetic agents. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

CVD risk only linked to sedentary activity at very high levels
Only very high levels of sedentary behaviour, such as sitting, watching television and driving, are associated with an increased risk of cardiovascular disease, show results of a meta-analysis of nine studies. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news

‘Improved diabetes screening’ needed for adolescents
Analysis of NHANES data between 2005 and 2014 shows that many US adolescents with diabetes are not aware that they have the condition, with this being most common among children of non-White ethnicity. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Postdiagnosis omega-3 intake may lower CRC mortality
Increasing intake of marine omega-3 polyunsaturated fatty acids after diagnosis could provide a colorectal cancer-related mortality benefit. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Colorectal cancer Source Type: news

Distinct connectivity subtypes found for behavioural variant frontotemporal dementia
Researchers have found four distinct patterns of network degeneration that may help classify patients with behavioural variant frontotemporal dementia. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Neurodegeneration Source Type: news

CML patients sustain increased risk of vascular events
Patients treated for chronic myeloid leukaemia have a higher risk of arterial and venous vascular events than their counterparts in the general population, suggest the results of a Swedish cohort study. (Source: MedWire News)
Source: MedWire News - July 20, 2016 Category: Consumer Health News Tags: Chronic myeloid leukaemia Source Type: news

‘Clinically important’ cardiovascular benefits with antidiabetic agents
Research focusing on the newer oral antidiabetic agents reveals “clinically important” reductions in cardiovascular outcomes and mortality, relative to no treatment, among patients treated in primary care. (Source: MedWire News)
Source: MedWire News - July 19, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

Outcomes may be good after ejection fraction recovery
Recovery from a reduced ejection fraction appears to be a predictor of good outcomes in patients with heart failure, a retrospective analysis shows. (Source: MedWire News)
Source: MedWire News - July 19, 2016 Category: Consumer Health News Tags: Heart failure Source Type: news

Mutations Explain Late Progression in Pembrolizumab-Treated Melanoma
Researchers have identified several genetic mutations in metastatic melanoma that are behind acquired resistance to programmed death 1 therapy. (Source: MedWire News)
Source: MedWire News - July 19, 2016 Category: Consumer Health News Tags: Melanoma Source Type: news

Revised MRI criteria improves MS diagnosis accuracy
Researchers believe that, when diagnosing multiple sclerosis, lesions in the symptomatic region should not be excluded, as stated in the McDonald dissemination in space criteria. (Source: MedWire News)
Source: MedWire News - July 19, 2016 Category: Consumer Health News Tags: Multiple sclerosis Source Type: news

Expanded INTERSTROKE confirms global hypertension impact
Hypertension accounts for around half of all strokes in all regions of the world, show the results of the second phase of INTERSTROKE. (Source: MedWire News)
Source: MedWire News - July 18, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

HF and ejection fraction both impact CABG outcomes
Both heart failure and reduced ejection fraction influence the outcomes of patients undergoing coronary artery bypass grafting, say researchers.  (Source: MedWire News)
Source: MedWire News - July 18, 2016 Category: Consumer Health News Tags: Heart failure Source Type: news

Post-MI heart failure increases cancer risk
Myocardial infarction survivors who have heart failure are more likely to develop cancer than their heart failure-free counterparts, indicates research published in the Journal of the American College of Cardiology. (Source: MedWire News)
Source: MedWire News - July 15, 2016 Category: Consumer Health News Tags: Heart failure Source Type: news

Disheartening result for cyclosporine A in nonshockable cardiac arrest
Administering cyclosporine A at the time of resuscitation of patients with nonshockable out-of-hospital cardiac arrest does not reduce the likelihood of subsequent multiple organ failure, shows the results of the CYRUS trial. (Source: MedWire News)
Source: MedWire News - July 15, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news

‘Strikingly’ low 1-year mortality recorded for TAVR device
Findings from the PARTNER trial of the SAPIEN3 transcatheter heart valve system support the use of transcatheter aortic valve replacement as “the preferred therapy” in high-risk and inoperable patients with aortic stenosis. (Source: MedWire News)
Source: MedWire News - July 14, 2016 Category: Consumer Health News Tags: Interventional cardiology Source Type: news

Genetic risk factors signal AD susceptibility in the very young
Genetic risk factors for Alzheimer’s disease appear to have an early effect on the brain and may allow the detection of susceptible young individuals before symptoms are present, findings from two studies in Neurology suggest. (Source: MedWire News)
Source: MedWire News - July 14, 2016 Category: Consumer Health News Tags: Alzheimer ' s disease Source Type: news

Statin primary prevention effect in FH quantified
A retrospective analysis suggests that statin therapy reduces the risk of a first coronary artery disease event or death in patients with familial hypercholesterolaemia by around 44%. (Source: MedWire News)
Source: MedWire News - July 14, 2016 Category: Consumer Health News Tags: Cardiometabolic Source Type: news

Studies expand beta-cell knowledge
Two studies reveal four distinct subtypes of β cells and a marker that can distinguish proliferative from mature cells. (Source: MedWire News)
Source: MedWire News - July 14, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news

MC1R gene variants drive up melanoma mutations
A study evaluating the association between melanocortin 1 receptor gene variants and somatic mutations in melanomas suggests that even individuals with a single copy of the MC1R variant may be susceptible to the mutagenic effects of sun damage. (Source: MedWire News)
Source: MedWire News - July 14, 2016 Category: Consumer Health News Tags: Melanoma Source Type: news

Absolute immature platelet count predicts thienopyridine response
An elevated absolute immature platelet count is a significant indicator of reduced inhibition of platelet aggregation in response to thienopyridine loading in stable patients undergoing percutaneous coronary intervention, German researchers report. (Source: MedWire News)
Source: MedWire News - July 13, 2016 Category: Consumer Health News Tags: Coronary heart disease Source Type: news

Sacubitril plus valsartan reduces early readmission risk in HF
The risk of readmission within 30 days of heart failure hospitalisation is reduced by a quarter for patients receiving sacubitril/valsartan compared with those receiving enalapril, an analysis of PARADIGM-HF trial data shows. (Source: MedWire News)
Source: MedWire News - July 13, 2016 Category: Consumer Health News Tags: Heart failure Source Type: news

High short-term mortality risk after recurrent diabetic ketoacidosis
More than one in five patients with Type 1 diabetes and recurrent hospital admissions for diabetic ketoacidosis die within a few years of an admission, research shows. (Source: MedWire News)
Source: MedWire News - July 13, 2016 Category: Consumer Health News Tags: Diabetes Source Type: news