Peptide mimetic of N ‐terminal ghrelin enhances ghrelin‐induced growth hormone secretion and c‐Fos expression in mice
Orexigenic peptide ghrelin and its receptor have been extensively investigated as potential therapeutic targets, primarily because of their role in feeding initiation and growth hormone (GH) release. However, no specific ghrelin targeting anti ‐obesity or cachexia therapeutics are available for clinical use thus far and further efforts in this direction are warranted. The present study aimed to find new peptide drug leads modulating ghrelin signal transduction. By targeting neutralising antibodies against ghrelin with phage display libr aries, we aimed to identify peptides binding to the cognate receptor. Four synthetic ...
Source: Journal of Neuroendocrinology - November 22, 2018 Category: Endocrinology Authors: Mojca Lunder, Miha Vodnik, Valentina Kubale, Ne ža Grgurevič, Gregor Majdič, Borut Štrukelj Tags: ORIGINAL ARTICLE Source Type: research

Grey matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women: A voxel ‐based morphometry study
AbstractThe present study aimed to explore brain morphological alterations associated with age and sex hormone levels between premenopausal and perimenopausal women using magnetic resonance imaging (MRI) T1‐weighted structural images. Thirty‐two premenopausal women aged (mean ± SD) 47.75 ± 1.55 years and twenty‐five recently perimenopausal women aged 51.60 ± 1.63 years were evaluated for sex hormone levels, including prolactin, follicle‐stimulating hormone, luteinising hormone, oest radiol, free testosterone and progesterone. A 3.0‐Tesla MRI scanner was utilised to acquire T1 images. Voxel ‐based mor...
Source: Journal of Neuroendocrinology - November 22, 2018 Category: Endocrinology Authors: Weizhao Lu, Wei Guo, Kun Hou, Huihui Zhao, Liting Shi, Kejiang Dong, Jianfeng Qiu Tags: ORIGINAL ARTICLE Source Type: research

Cracking the Combination: Gut Hormones for the Treatment of Obesity and Diabetes
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 22, 2018 Category: Endocrinology Authors: Kleopatra Alexiadou, Olawaseun Anyiam, Tricia Tan Tags: Review Article Source Type: research

Grey matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women: A voxel ‐based morphometry study
AbstractThe present study aimed to explore brain morphological alterations associated with age and sex hormone levels between premenopausal and perimenopausal women using magnetic resonance imaging (MRI) T1‐weighted structural images. Thirty‐two premenopausal women aged (mean ± SD) 47.75 ± 1.55 years and twenty‐five recently perimenopausal women aged 51.60 ± 1.63 years were evaluated for sex hormone levels, including prolactin, follicle‐stimulating hormone, luteinising hormone, oest radiol, free testosterone and progesterone. A 3.0‐Tesla MRI scanner was utilised to acquire T1 images. Voxel ‐based mor...
Source: Journal of Neuroendocrinology - November 21, 2018 Category: Endocrinology Authors: Weizhao Lu, Wei Guo, Kun Hou, Huihui Zhao, Liting Shi, Kejiang Dong, Jianfeng Qiu Tags: ORIGINAL ARTICLE Source Type: research

Gray matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women, a voxel ‐based morphometry study
ConclusionThe VBM analysis revealed that age and menopause per se lead to gray matter volume reduction in certain brain structures. These structural changes might be potential causes of sexual dysfunction, nervous system degeneration and depression, which need to be examined in future studies. Our findings might provide evidence and guide future research in understanding the menopausal transition.This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 21, 2018 Category: Endocrinology Authors: Weizhao Lu, Wei Guo, Kun Hou, Huihui Zhao, Liting Shi, Kejiang Dong, Jianfeng Qiu Tags: Original Article Source Type: research

Ghrelin receptor deletion reduces binge ‐like alcohol drinking in rats
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 20, 2018 Category: Endocrinology Authors: L.J. Zallar, S. Beurmann, B.J. Tunstall, C.M. Fraser, G.F. Koob, L.F. Vendruscolo, L. Leggio Tags: Original Article Source Type: research

The osmoresponsiveness of oxytocin and vasopressin neurones: mechanisms, allostasis and evolution
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 19, 2018 Category: Endocrinology Authors: Gareth Leng, John A. Russell Tags: Review Article Source Type: research

Menopause is associated with decreased postprandial ghrelin, while a history of anorexia nervosa is associated with increased total ghrelin
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 17, 2018 Category: Endocrinology Authors: Suzana Stojiljkovic ‐Drobnjak, Susanne Fischer, Myrtha Arnold, Wolfgang Langhans, Ulrike Ehlert Tags: Original Article Source Type: research

Sex ‐ and sub region‐dependent modulation of arcuate kisspeptin neurons by vasopressin and vasoactive intestinal peptide
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 13, 2018 Category: Endocrinology Authors: Danielle Schafer, Grace Kane, William H. Colledge, Richard Piet, Allan E. Herbison Tags: Original Article Source Type: research

Differential effects of chronic 17 β‐oestradiol treatment on rat behaviours relevant to depression
Sex differences are a prominent feature of the pathophysiology of psychiatric disorders, such as major depressive disorder, which affects women at a higher incidence than men. Research suggests that the most potent endogenous oestrogen, 17 β‐oestradiol, may have therapeutic potential in treating depression. However, preclinical studies have produced mixed results, likely as a result of various methodological factors such as treatment duration. The present study aimed to investigate the effects of ovariectomy and chronic 17β‐oest radiol treatment via a s.c. silastic implant on behaviours relevant to depression in adul...
Source: Journal of Neuroendocrinology - November 13, 2018 Category: Endocrinology Authors: Andrea Gogos, Madeleine McCarthy, Adam J. Walker, Madhara Udawela, Andrew Gibbons, Brian Dean, Snezana Kusljic Tags: ORIGINAL ARTICLE Source Type: research

A novel GNRHR gene mutation causing Congenital Hypogonadotropic Hypogonadism (CHH) in a Brazilian Kindred
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 11, 2018 Category: Endocrinology Authors: Silvia Regina Correa ‐Silva, Jessica da Silva Fausto, Marina Malta Letro Kizys, Rafael Filipelli, David Santos Marco Antonio, Andre Yuji Oku, Gilberto Koiti Furuzawa, Eugenia Verônica Hernandez Orchard, Flavia Amanda Costa‐Barbosa, Miguel Mi Tags: Original Article Source Type: research

Interplay of central and peripheral circadian clocks in energy metabolism regulation
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 11, 2018 Category: Endocrinology Authors: Isa Kolbe, Niklas Brehm, Henrik Oster Tags: Review Article Source Type: research

Mapping GABA and Glutamate inputs to gonadotropin ‐releasing hormone (GnRH) neurones in male and female mice
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 11, 2018 Category: Endocrinology Authors: Aleisha M. Moore, Georgina Abbott, Jonathan Mair, Melanie Prescott, Rebecca E. Campbell Tags: Original Article Source Type: research

Peptide mimetic of N ‐terminal ghrelin enhances ghrelin induced growth hormone secretion and c‐Fos expression in mice
Journal of Neuroendocrinology,Volume 0, Issue ja, -Not available-. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - November 5, 2018 Category: Endocrinology Authors: Mojca Lunder, Miha Vodnik, Valentina Kubale, Ne ža Grgurevič, Gregor Majdič, Borut Štrukelj Source Type: research

Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone ‐treated mice
Journal of Neuroendocrinology, EarlyView. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 31, 2018 Category: Endocrinology Authors: Mar ía L. Leicaj, Laura A. Pasquini, Analia Lima, Maria C. Gonzalez Deniselle, Juana M. Pasquini, Alejandro F. De Nicola, Laura I. Garay Source Type: research