IRIS: Best Candidates for Pioglitazone After Stroke IRIS: Best Candidates for Pioglitazone After Stroke

Stroke patients with insulin resistance who are at greatest risk for repeat stroke derive the greatest benefit from pioglitazone treatment.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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Ischemic stroke damages the blood-brain barrier (BBB), which leads to brain edema and increases the risk of intracranial hemorrhage. Proteasome inhibition has been found to protect the BBB against cerebral ischemia by suppressing neuroinflammation-mediated matrix metalloproteases-9 (MMP-9) activation. We recently showed that ginsenoside Rd (Rd), a major active ingredient of Panax ginseng, could suppress proteasome-mediated inflammation and be efficient for treating ischemic stroke but downstream mechanisms were still unidentified. For this purpose, Sprague–Dawley rats were subjected to focal cerebral ischemic injury....
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
AbstractThe utility of abdominal aortic calcification (AAC) for prediction of cardiovascular events (CVEs) in patients with acute coronary syndrome (ACS) remains to be determined. The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a co...
Source: Heart and Vessels - Category: Cardiology Source Type: research
Condition:   Stroke Interventions:   Device: Robotic group (Upper extremity robot-assisted training plus routine physical and rehabilitation medicine program);   Behavioral: Control group (routine physical and rehabilitation medicine program) Sponsor:   Ankara University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A friend of mine takes a statin medication each day to lower his cholesterol. More than once I’ve heard him say “I ate too much! I’m going to have to take an extra pill.” Never mind that it doesn’t work that way — a single additional statin pill won’t make much difference to his cholesterol or his health. And never mind that you shouldn’t self-adjust the dose of your medications (talk to your doctor before making any changes in medication dosing). But my friend’s overindulging does bring up the question of whether starting medications for conditions like high blood pres...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Health Healthy Eating Heart Health Hypertension and Stroke Source Type: blogs
UK experts are concerned that people are not seeking urgent NHS help when they need it.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
This cohort study examines a system for prehospital triage for Swedish patients with suspected acute stroke.
Source: JAMA Neurology - Category: Neurology Source Type: research
Current guidelines state that patients who experienced a stroke should usually be transferred to the nearest stroke-treating hospital. In accordance with these guidelines, most patients with large-vessel occlusion (LVO) are transported to a primary stroke center (PSC) that does not offer thrombectomy. From there, these patients must undergo a secondary interhospital transport to a thrombectomy-capable comprehensive stroke center (CSC). Such secondary transfers cause considerable treatment delays, ranging from 96 to 111 minutes. Even when the distance between the PSC and a CSC is only 15 miles, transfer times of 104 minutes have been reported.
Source: JAMA Neurology - Category: Neurology Source Type: research
We describe a new method to induce focal brain damage targeting the motor cortex to study damage to the descending motor tracts in the non-human primate. Stereotaxic injection of malonate into the primary motor cortex produced a focal lesion in middle-aged marmosets (Callithrix jacchus). Assessment of sensorimotor function using a neurological scale and testing of forelimb dexterity and strength lasted a minimum of 12  weeks. Lesion evolution was followed by magnetic resonance imaging (MRI) at 24 h, 1 week, 4 and 12 weeks post-injury and before sacrifice for immunohistochemistry. Our model produced consistent les...
Source: Translational Stroke Research - Category: Neurology Source Type: research
I discussed the use of hydroxychloroquine and azithromycin for patients with COVID19 on my March 27th edition of This Week in Cardiology Podcast. This is an important topic not only because of the specifics of treating patients but also vital because it shows how easily human beings can be misled. Here is a an edited transcript of my words: A conversation I had with my Dad this week made me realize the seriousness of this matter. My Dad is a retired insurance executive with a background in electrical engineering.  He is smart, but I could not convince him that the evidence prompting people to advoc...
Source: Dr John M - Category: Cardiology Authors: Source Type: blogs
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