Immunotherapy and potential molecular targets for the treatment of pituitary adenomas resistant to standard therapy: a critical review of potential therapeutic targets and current developments.
CONCLUSIONS: Rapid advancements in tumor immunology may increase the probability of successful treatment of PAs by exploitation of the normal immune response or by targeting novel proteins. Current research on many of the targets reviewed in this article are successfully being utilized to manage various neoplastic disease including CNS tumors. These therapies may eventually play a key role in the treatment of PAs that do not respond to standard therapy. PMID: 30014686 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - July 18, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The impact of Type 2 Diabetes on the peri- and postoperative outcomes of minimally invasive fusion techniques in the lumbar spine.
CONCLUSIONS: T2DM is not a risk factor for the occurrence of complications in MAST. PMID: 30014687 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - July 18, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Fluorescent tracers in neurosurgical procedures: an European survey.
CONCLUSIONS: 5-ALA acid is still the preferred and more established fluorescent dye used during high-grade gliomas resection, with SF as a gaining-attention, really cheaper and more ductile alternative. PMID: 30014688 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - July 18, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

A rare case of multiple schwannomas originating from a single cauda equina root.
Authors: Fiaschi P, Cagetti B, Badaloni F, Padolecchia R, Pavanello M, Valsania V PMID: 29952470 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Surgical management of traumatic brain injury.
Authors: Pujari R, Hutchinson PJ, Kolias AG Abstract Traumatic brain injury (TBI) remains a leading cause of mortality and disability worldwide. Surgical intervention is one of the main pillars of TBI management. The mainstay of treatment for substantial intracranial haematomas is surgical evacuation. In addition, patients with TBI may have brain swelling and increased intracranial pressure (ICP). If the latter is refractory to medical management, surgical interventions can be helpful. In this review we seek to outline the major tenets of the surgical management of TBI. PMID: 29952471 [PubMed - as supplied by p...
Source: Journal of Neurosurgical Sciences - June 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit ®.
Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®. J Neurosurg Sci. 2018 Aug;62(4):423-427 Authors: Belcaro G, Saggino A, Cornelli U, Luzzi R, Dugall M, Hosoi M, Feragalli B, Cesarone MR Abstract BACKGROUND: Oxidative stress (OS) plays a substantial role in inflammatory and neurodegenerative diseases, causing cellular damage and mitochondrial dysfunction. OS also contributes to aging and severe neural disorders such as Alzheimer's and Parkinson's diseases. Previous registries have documented a reduction in OS levels with Robuvit® (Horp...
Source: Journal of Neurosurgical Sciences - June 28, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Endoscopic washout for medically refractory cerebral ventriculitis.
Authors: Yuen J, Chen B, Brent A, Plaha P PMID: 29938481 [PubMed - in process] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 28, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Simultaneous supratentorial anaplastic and infratentorial low grade ependymomas with distinct genetic profiles.
Authors: Wang JL, Hong CS, Henderson EY, Salma A, Heerema NA, Ray-Chaudhury A, Elder JB PMID: 29938482 [PubMed - in process] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 28, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Accuracy of percutaneous pedicle screws for thoracic and lumbar spine fractures compared with open technique.
This study aimed to compare the accuracy of screw placement between open pedicle screw fixation and percutaneous pedicle screw fixation (MIS) for the treatment of thoracolumbar spine fractures (TSF). MATERIALS AND METHODS: Forty-nine patients with acute TSF who were treated with transpedicular screw fixation from January 2013 to December 2016 were retrospectively reviewed. The patients were divided into Open and MIS groups. Laminectomy was performed in either group if needed. The accuracy of the screw placement, the evolution of the Cobb sagital angle postoperatively and at 12-month follow up and the neurological statu...
Source: Journal of Neurosurgical Sciences - June 17, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Clinical-neurophysiological-neuroradiological discordance in lumbar spine degenerative pathology: the last word to the neurosurgeon?
Authors: Chirchiglia D, Chirchiglia P, Murrone D, Signorelli F PMID: 29905431 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 17, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Outcome of elderly patients undergoing intracranial meningioma resection: a single center experience.
CONCLUSIONS: Even though the fragility is considered an important risk factor, surgery for symptomatic intracranial meningiomas should be considered also in elderly patients. The presence of early postoperative mild complications do not seem to worsen the average 6 months- KSP score. PMID: 29808631 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Lumbar canal stenosis: can we treat it endoscopically? Our experience.
CONCLUSIONS: The use of the endoscopic technique for the treatment of lumbar canal stenosis seems to be correlated with good results and can be a valid alternative to the classic, more invasive, open technique. PMID: 29808632 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Spontaneous regression of a discal cyst: a physiopathological hypothesis.
Authors: Zekaj E, Franzini A, Bona AR, Servello D PMID: 29808633 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

In vitro fertilization (IVF) and hormone-dependent brain tumors: could the new era of IVF and social freezing change our incidentally discovered brain tumor management?
Authors: Cardia A, Zerbetto I, Cannizzaro D, Picozzi P, Fornari M, Levi Setti P, Servadei F PMID: 29808634 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Endoscopic endonasal approaches for the management of skull base meningiomas. Selection criteria and clinical outcomes.
CONCLUSIONS: The EEA is not an ideal approach for every skull base meningioma. Careful evaluation of the surrounding neurovascular structures surrounding the tumor is imperative to select the appropriate surgical corridor for a safe resection. Nevertheless, for appropriately selected cases, the endoscopic technique is a very valuable tool with some evidences of being superior to the microscopic transcranial approach. A dual-trained surgeon, in both endoscopic and transcranial approaches, is the best alternative to achieve the best patient outcome. PMID: 29808635 [PubMed - as supplied by publisher] (Source: Journal of N...
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Application of PHASES and ELAPSS scores to ruptured cerebral aneurysms: how many would have been conservatively managed?
CONCLUSIONS: A reasonable percentage of ruptured aneurysms have a low calculated PHASES score and these aneurysms may have been managed conservatively should they have presented incidentally prior to rupture. The majority of ruptured aneurysms also had a low ELAPSS score and were at low risk of future growth. The use PHASES score and ELAPSS score alone when making treatment decisions could result in many aneurysms being treated conservatively or undergoing remote surveillance despite rupture potential. PMID: 29808636 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Endoscopic endonasal approaches for the management of cranial base malignancies: histologically guided treatment and clinical outcomes.
Authors: Vankoevering K, Prevedello DM, Carrau RL Abstract Malignancies of the skull base represent a highly diverse and challenging set of pathologies which exhibit a wide array of oncologic behavior. In recent decades, a number of important advances in treatment technique have evolved to improve oncologic outcomes and reduce morbidity in the treatment of these aggressive cancers. Intensity modulated radiation therapy (IMRT) has become the gold standard in radiotherapy owing to its precision planning and reduced morbidity. However heavy ion particle radiation (proton therapy, carbon ion, etc.) are recently emergin...
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Long term outcome following severe traumatic brain injury: ethical considerations.
Authors: Honeybul S Abstract There is now no little doubt that decompressive craniectomy can reduce mortality following severe traumatic brain injury. However the concern has always been that the reduction in mortality comes at the cost of an increase in the number of survivors with severe neurological disability. It was these concerns that prompted investigators to conduct a number of large multicentre randomised trials investigating surgical efficacy of the procedure. Whilst the results of these trials have confirmed the survival benefit that can be achieved this has only been achieved by increasing the number of...
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive approaches for the management of intraventricular hemorrhage.
Authors: Abunimer AM, Abou-Al-Shaar H, Cavallo C, Mahan MA, Labib MA Abstract Adult-onset intraventricular hemorrhage is a potentially life-threatening condition associated with a high morbidity and mortality rates. Intraventricular hemorrhage remains one of the most challenging entities for neurosurgeons to treat. Various medical and surgical modalities have been employed for the management of this entity with variable success and complications rates. In this paper, we review the neurosurgical interventions for the management of intraventricular hemorrhage and describe new approaches and potential therapeutic moda...
Source: Journal of Neurosurgical Sciences - June 1, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive endoscopic-assisted approaches to the posterior fossa.
Authors: Yang A, Folzenlogen Z, Youssef AS Abstract Modern surgical approaches are becoming more minimalistic, associated with the term 'minimally invasive'. The endoscope provides a more panoramic anatomical view in addition to the ability to access narrow deep corners with decent illumination and clear visualization. Endoscopic assisted microsurgery through a tailored small craniotomy is the foundation of keyhole surgery. The endoscope can be advanced deeper into the field, thus enhancing an exposure and allowing bimanual dissection, thus prompting smaller craniotomies and tailored key exposures. The term 'minima...
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Training the skull base surgeon of the future: a comprehensive approach.
Authors: Aref M, Youssef AS Abstract The tremendous advances in endoscopic skull base surgery added new a set of intricate less invasive approaches to the neurosurgical armamentarium. The new generations of neurosurgeons face the challenge of adopting the ever-changing technology and quickly learning modern surgical techniques beyond the traditional neurosurgery comfort zone. The future skull base surgeon must be well trained and knowledgeable in all surgical portals to the skull base in order to select the safest least invasive, most direct approach that offers the optimum exposure to handle a complex skull base p...
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Neuroprotection in traumatic brain injury.
CONCLUSIONS: Traumatic brain injury has wide spread implications and the socio-economic burden related to TBI has been rising. Traumatic Brain Injury is a challenging disease to intervene on due to its heterogeneity. Studies have been limited by several factors outlined in this article. Future work should incorporate a multicenter approach targeting specific disease processes to yield successful results. PMID: 29790724 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The utilization of fluorescein in brain tumor surgery: a systematic review.
CONCLUSIONS: Fluorescein-guided surgery is a safe and effective technique to improve visualization and resection of different CNS tumors and conditions, based on BBB alteration, with a growing evidence-based background. PMID: 29790725 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive approaches to craniosynostosis.
Authors: Pendharkar AV, Shahin MN, Cavallo C, Zhao X, Ho AL, Sussman ES, Grant GA Abstract Craniosynostosis (CS) is defined as the premature fusion of one or more calvarial sutures. This carries several consequences, including abnormal/asymmetric cranial vault development, increased intracranial pressure, compromised neurocognitive development, and craniofacial deformity. Definitive management is surgical with the goal of protecting cerebral development by re-establishing normal cranial vault expansion and correcting cosmetic deformity. In today's practice, CS surgery has advanced radically from simple craniectomie...
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Pathophysiology of severe traumatic brain injury overview.
Authors: O'leary RA, Nichol AD Abstract Traumatic brain injury is a leading cause of morbidity and mortality globally, particularly among young people, with significant social and economic effects. The World Health Organization (WHO) estimates that more than five million people die each year from traumatic injuries worldwide. While public health initiative such as seatbelts and airbags have had a major impact, it will be impossible to prevent traumatic brain injury, it is therefore that we understand the pathophysiology of secondary brain injury to be able to effectively treat our patient but aloes to develop novel...
Source: Journal of Neurosurgical Sciences - May 26, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Pycnogenol ® supplementation in minimal cognitive dysfunction.
Pycnogenol® supplementation in minimal cognitive dysfunction. J Neurosurg Sci. 2018 Jun;62(3):279-284 Authors: Hosoi M, Belcaro G, Saggino A, Luzzi R, Dugall M, Feragalli B Abstract BACKGROUND: Impairments in cognitive function are difficult to evaluate and measure. In most cases, subjects do not perceive any alteration in their own status, particularly in case of mild cognitive impairment. In case of minimal alterations of cognitive function, no real treatment exists at the moment. Functional and/or temporary alterations in the cerebral microcirculation may be involved in cognitive impairment, and...
Source: Journal of Neurosurgical Sciences - May 15, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Spinal epidural lipomatosis: a rare condition with unclear etiology.
Authors: Donnarumma P, Nigro L, Ambrosone A, Tarantino R, Santoro A, Delfini R PMID: 29745217 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - May 12, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Do antiplatelet and anticoagulant drugs modify outcome of patients treated for chronic subdural hematoma? Still a controversial issue.
Authors: Scerrati A, Mangiola A, Rigoni F, Olei S, Santantonio M, Trevisi G, Anile C, Cavallo MA, De Bonis P Abstract BACKGROUND: Anticoagulants(ACs) and antiplatelet aggregation agents(AAAs) seem to be correlated to a higher incidence of chronic subdural hematoma(CSDH) but whether or not they contribute to its recurrence is debated. Few data are available on clinical outcomes and indications for the management of this therapy are not so well defined. We investigated the role of ACs and AAAs in modifying patients clinical outcomes treated for CSDH, especially for re-bleedings. METHODS: This retrospective study,...
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Fronto-mesial-pericallosal gliofibroma.
Authors: Amoroso R, Weiss A, Pieri F, Zucchi V, Bosio M, Stasi I, Santonocito O PMID: 29671292 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Surgical treatment for refractory epilepsy.
Authors: Herta J, Dorfer C Abstract The goal of any epilepsy surgery is to improve patient ́s quality of life by achieving seizure freedom or by reducing the frequency of severely debilitating seizures. To achieve this goal, non-invasive and invasive diagnostic methods must precisely delineate the epileptogenic zone (EZ), which is defined as the area that needs to be resected to obtain seizure freedom. At the same time, the correct identification of eloquent brain areas is inevitable to avoid new neurological deficits from surgery. In recent years, the technical advances in diagnostics have enabled us to achieve t...
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Standard of care, controversies and innovations in the medical treatment of Severe Traumatic Brain Injury (STBI).
Authors: Scerrati A, De Rosa S, Mongardi L, Cavallo MA, Trapella G, De Bonis P Abstract Severe traumatic brain injury (STBI) is characterized by a primary injury which cannot be reversed and a secondary injury that can be prevented or reversed. Management of STBI patients in intensive care mainly aims at preventing the secondary injury. Treatment aims to: reducing ICP pressure (that can result in an ischemic insult); avoiding hypotension, hyperthermia, or hypoxemia; maintaining a normal electrolytes homeostasis; treating the Autonomic dysfunction syndrome, coagulopathies, Acute Kidney Injury and maintaining an adeq...
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Monitoring the injured brain.
Authors: Mazzeo AT, Gupta DK Abstract Traumatic brain injury can be defined as the most complex disease in the most complex organ. When an acute brain injury occurs, several pathophysiological cascades are triggered, leading to further exacerbation of the primary damage. A number of events potentially occurring after TBI can compromise the availability or utilization of energy substrates in the brain, ultimately leading to brain energy crisis. The frequent occurrence of secondary insults in the acute phase after TBI, such as intracranial hypertension, hypotension, hypoxia, hypercapnia, hyperthermia, seizures, can t...
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive tubular retractor-assisted biopsy and resection of subcortical intra-axial gliomas and other neoplasms.
We describe our experience with the use of tubular retractors for accessing these deep-seated lesions. Fifty consecutive patients operated on for an intra-axial brain tumor (both biopsies and resection) from January 2016 to December 2017 by a single surgeon using tubular retractors with exoscopic visualization were prospectively identified and included in this consecutive case series. 35 patients (70%) underwent surgical resection and 15 (30%) underwent excisional biopsy for tumors located a median [interquartile range (IQR)] distance of 5.4 [4.5-6.1] cm below the cortical surface within the thalamus and/or basal ganglia i...
Source: Journal of Neurosurgical Sciences - April 21, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive posterior extraforaminal approach for presacral schwannoma of L5: a technical note.
Authors: Cipolleschi E, Wembagher GC, Barni I, Romoli S PMID: 29658685 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - April 18, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Management decisions in treating large vestibular schwannoma: a staged technique.
Authors: Schutt CA, Larouere M, Bojrab DI, Jacob J, Babu S PMID: 29658686 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - April 18, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The course of intracranial pressure after antipyretic therapy in acute brain injury.
Authors: Picetti E, Ceccarelli P, Malchiodi L, Mensi F, Risolo S, Servadei F, Iaccarino C, Rossi I, Rossi S Abstract BACKGROUND: The present study was performed to evaluate intracranial pressure (ICP) variations after antipyretic therapy and their relationship to ICP at baseline (ICPbas) in acute brain injury (ABI) patients. METHODS: We completed a retrospective analysis on data derived from 2 previously published prospective observational studies. The first study involved 32 ABI patients and was performed to elucidate the cerebral and hemodynamic effects of intravenous (IV) paracetamol. The second study involv...
Source: Journal of Neurosurgical Sciences - April 7, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Fluorescence-assisted surgery in the interhemispheric transcallosal approach for thalamic lesions.
Authors: de Laurentis C, Acerbi F, Schiariti MP, Ferroli P PMID: 29618197 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - April 7, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The endoscopic surgical resection of intrasellar lesions conserves the hormonal function: a negative correlation to the microsurgical technique.
Authors: Linsler S, Senger S, Hero-Gross R, Steudel WI, Oertel J Abstract BACKGROUND: The endonasal endoscopic approach is still currently under investigation for sellar tumour surgery: a higher resection rate is to be expected and complications should be minimized. The authors report their surgical results of endonasal endoscopic neurosurgery with special focus on postoperative hypopituitarism in comparison to microsurgical procedures. METHODS: Sixty patients received endoscopic endonasal transsphenoidal procedures for sellar pathologies. All patients were followed up prospectively. A second group of 60 patien...
Source: Journal of Neurosurgical Sciences - March 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Brain arteriovenous malformations: an ongoing challenge.
Authors: Bervini D PMID: 29595046 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Natural history of brain arteriovenous malformations: systematic review.
CONCLUSIONS: Previously ruptured bAVMs have a higher annual hemorrhage rate than enraptured bAVMs. Deep bAVM location and prior hemorrhage may increase the risk for subsequent hemorrhage. PMID: 29595047 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The Cobra effect: a venomous snake in the neurosurgical field.
Authors: Fontanella M PMID: 29595048 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 30, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Tubular resection of a deep-seated motor cortex lesion.
Authors: Revuelta Barbero JM, Yanez-Siller JC, Villalonga JF, Prevedello DM PMID: 29582968 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Incidence and risk factors of neurosurgical site infections: results of a prospective multicenter cohort study on 6359 surgeries.
CONCLUSIONS: The subjects submitted to complicated, repeated, long lasting craniotomies, especially if experiencing postoperative deterioration, display the higher risk of SSIs, as a final life threatening complication. In order to reduce the SSI rate, further studies should address to design tailored prophylaxis protocols for each high risk situation as hereby defined; the wound complications deserve an increased microbiological surveillance, focusing the attention on the timing and source of infections. PMID: 29582969 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Use of 4K resolution in endoscopic endonasal neurosurgery: our experience.
Authors: Fiaschi P, Prior A, Ceraudo M, Zona G, Criminelli Rossi D PMID: 29582970 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Proton beam radiation-induced glioblastoma multiforme.
Authors: Schutt CA, Sargent E, Kabolizadeh P, Grills IS, Jacob J PMID: 29582971 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

A new method of skin disinfection for spinal surgery: a prospective study on 918 patients. Our results.
Authors: Tacconi L, Bobicchio P PMID: 29582972 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Transforaminal percutaneous endoscopic lumbar discectomy: outcome and complications in 270 cases.
CONCLUSIONS: The transforaminal percutaneous endoscopic lumbar discectomy is a safe and effective procedure to treat lumbar disc prolapsed. Surgical experience and correct patients' selection are crucial factors affecting the outcome. PMID: 29582973 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Contemporary tools in AVM surgery.
Authors: Cenzato M, Dones F, Boeris D, Marcati E, Fratianni A, Crisà FM, Debernardi A Abstract Arteriovenous malformations (AVMs) are rare entities and therefore considered the main challenge for a neurosurgeon. Since the publication of the ARUBA study, one of the most popular debate regards the actual surgical indication for unruptured AVMs. Our group recently published a multicenter review of more than 500 cases underlying the important role of surgery. In the last decades, the expanding technologies used in the treatment of AVMs have shown an ongoing improvement overcoming some of the existing difficultie...
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Feasibility of endoscopic endonasal approach for clip application of cerebral aneurysms: a systematic review.
CONCLUSIONS: Despite a moderate increase in utilization, caution should be exercised when choosing an endonasal strategy for treatment of aneurysmal pathology over more traditional and established methods such as microsurgical clip application and endovascular methods. Anecdotal evidence suggests that inferior and/or medial projecting aneurysms involving the paraclinoid ICA not amenable to traditional open/endovascular strategies may be reasonable to consider for EEA clip application. Wide-necked, midline, ventrolaterally-projecting aneurysms involving the vertebrobasilar system may represent an additional exception, as lo...
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Radiosurgery and radiotherapy for arteriovenous malformations: outcome predictors and review of the literature.
Authors: Vlaskou Badra E, Ermiş E, Mordasini P, Herrmann E Abstract Arteriovenous malformations (AVMs) are rare congenital vascular pathologies. The reported overall annual hemorrhage rate is 3.0%, for unruptured AVMs it is 2.2%, and for ruptured AVMs, 4.5%. The main goal of AVM treatment is to prevent intracerebral hemorrhage. This is achieved by complete nidus eradication. Interventional treatment options include microsurgery, embolization and radiosurgery, as well as multimodal approaches. Radiosurgery is a safe and effective alternative to surgery or embolization, especially for AVMs located in deep or eloquen...
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research