The seven miracles of Neurosurgery.
Authors: Syrmos N PMID: 32043845 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Are familial colloid cysts of the third ventricle associated with a worse clinical course than sporadic forms? Case illustration and systematic literature review.
Authors: Muscas G, Battista F, Serra C, Boschi A, Noubari BA, Della Puppa A Abstract BACKGROUND: The incidence of asymptomatic colloid cysts is increasing due to the widespread use of neuroimaging tools. According to previous works, familial forms (within first-degree relatives) represent 5-25% of the cases, and it is not clear whether they display specific features influencing the clinical behavior of the disease. METHODS: We reviewed the literature to extract data from papers dealing with familial colloid cysts. For comparison, previous series dealing with the natural history of sporadic cases were identified...
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Shifting from the directly observation via eyepiece lens to the monitor viewing of the surgical field: a new era for the microsurgery in neurosurgery.
Authors: Stefini R PMID: 32043847 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Impact of 4K ultra-high definition endoscope in pituitary surgery: analysis of a comparative institutional case series.
CONCLUSIONS: The HD endoscope remains the standard-of-care for pituitary surgery. The 4K enhanced, "immersive" visualization significantly improved the reliability of surgeon's judgment on resection and might be useful in surgically difficult cases. PMID: 32043848 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Enhancement of miR-16-5p on spinal cord injury-induced neuron apoptosis and inflammatory response through inactivating ERK1/2 pathway.
CONCLUSIONS: Downregulation of miR-16-5p could upregulate Apelin-13 expression to activate ERK1/2 pathway, thus alleviating SCI-induced neuron apoptosis and inflammatory response. PMID: 32043849 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

A letter to the Editor regarding "Reducing radiation exposure in spinal surgery".
A letter to the Editor regarding "Reducing radiation exposure in spinal surgery". J Neurosurg Sci. 2020 Feb 10;: Authors: Brady Z, Arif S, Enchev Y, Peev N, Encheva E PMID: 32043850 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Minimally invasive percutaneous anterior odontoid screw fixation: institutional experience with a simple and effective technique.
CONCLUSIONS: In our opinion, this modified percutaneous minimally invasive technique for anterior odontoid screw fixation, along with the use of a soft tissue dilator not fixed to the spine, has not yet been reported in literature and is strongly recommended to reduce invasiveness of odontoid screw placement. PMID: 32043851 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 13, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

MiR-29a protects against cerebral ischemia injury by targeting DPP4 through TGF- β signaling pathway.
MiR-29a protects against cerebral ischemia injury by targeting DPP4 through TGF-β signaling pathway. J Neurosurg Sci. 2020 Feb 03;: Authors: Wu Z, Wang S, Jin X, Bi Y, Ma S, Liu T PMID: 32030963 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

MicroRNA-181a inhibition relieves cerebral ischemia/reperfusion injury via regulation of TGFBR1.
Authors: Wang L, Li J, Ning F, Yang S, Yan X PMID: 32030964 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Isoflurane improves cerebral ischemia-reperfusion injury in rats via activating MAPK signaling pathway.
Authors: Liu G, Qiao S, Yu Y, Zhang X, Li N, Hou D PMID: 32030965 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Investigation of key miRNAs and their target genes involved in cell apoptosis during intervertebral disc degeneration development using bioinformatics methods.
CONCLUSIONS: The expression of GSK3B may be coregulated by miR-4306, miR-185-5p, miR-486-5p, hsa-let-7f-1-3p, and miR-631 and may affect IDD development. Besides, miR-185-5p and miR-3675-3p may control nucleus pulposus (NP) cell apoptosis through the MAPK signaling pathway in IDD patients. VEGFA expression may be regulated by miR-631, and help maintain NP cell survival in IDD patients. Our findings may help guide further research into the role of miRNAs in IDD progression. PMID: 32031354 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats.
Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats. J Neurosurg Sci. 2020 Feb 04;: Authors: Shimoda Y, Nakayama N, Moriwaki T, Abumiya T, Kawabori M, Kurisu K, Gekka M, Hokari M, Ito Y, Houkin K Abstract BACKGROUND: It is necessary and useful to obtain an experimental model which steadily and rapidly induces aneurysms for investigation of the pathogenesis of cerebral aneurysm. We attempted to examine whether intraperitoneal administration of β-aminopropionitrile fumarate (BAPN-F) with additional treatments of induced hypertens...
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Visualization of volume of tissue activated modeling in a clinical planning system for deep brain stimulation.
CONCLUSIONS: VTA visualization in a clinical planning system allows an intuitive adjustment of the stimulation parameters, supports programming, and enhances understanding of effects and side effects of DBS. PMID: 32031356 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Postoperative stereotactic radiosurgery and hypofractionated radiotherapy for brain metastases using Gamma Knife and CyberKnife: a dual-center analysis.
CONCLUSIONS: Both SRS and hFSRT provide high local control rates in resected BM regardless of the applied modality. PMID: 32031357 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Monosialoganglioside improves Parkinson's disease in rats by inhibiting neuronal apoptosis through ERK1/2 signaling pathway.
Authors: Gao F, Han J, Wang Y PMID: 32031358 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Cognitive characteristics of children treated for deformational plagiocephaly and parental perception of the therapy.
CONCLUSIONS: Our results suggest that, in absence of medical conditions affecting cognitive performance, cognitive abilities of children aged 2-7y treated for DP either by MHT or RT are undisturbed. Although majority of parents are satisfied with chosen therapy, those whose children have better cognitive performance are more likely to rate therapy higher. PMID: 32031359 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Glioblastoma: from volumetric analysis to molecular predictors.
CONCLUSIONS: In this investigation longer survival is associated with younger age, EOR, promoter methylation of MGMT and preoperative tumor volumetric features expressed by ΔT1-T2 MRI index. The preoperative ΔT1-T2 MRI index could be a promising prognostic factor potentially useful in GBM management. Future investigations based on multiparametric MRI data and next generation sequences analysis, may better clarify this result. PMID: 32031360 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Supplementary management with Pycnogenol ® in Parkinson's disease to prevent cognitive impairment.
Supplementary management with Pycnogenol® in Parkinson's disease to prevent cognitive impairment. J Neurosurg Sci. 2020 Jan 20;: Authors: Cesarone MR, Belcaro G, Hosoi M, Ledda A, Feragalli B, Maione C, Scipione C, Scipione V, Cotellese R, Hu S Abstract BACKGROUND: The aim of this registry study in patients with Parkinson's Disease (PD) in treatment, was to evaluate the effects of Pycnogenol® supplementation on some accessory symptoms and cognitive functions (COFU). METHODS: The registry included 43 PD patients who had been diagnosed at least one year before the registry. The condition was ...
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

State of the art of fluorescence guided techniques in neurosurgery.
Authors: La Rocca G, Della Pepa GM, Menna G, Altieri R, Ius T, Rapisarda A, Olivi A, Sabatino G Abstract Achieving a safe and extensive neoplasm resection can be considered the main goal of brain tumor surgery. This paper is first aimed at providing an overview of the evolution of those tools serving the purpose. From the dawn of neurosurgery to the present days, major innovations have followed one another. However, those techniques may frequently lack of an instant biological feedback on the true extension and the infiltration of the tumor. Intraoperative fluorescence modalities could indeed fill this gap. Fluores...
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection.
Authors: Navarro-Bonnet J, Suarez-Meade P, Brown DA, Chaichana KL, Quinones-Hinojosa A Abstract Gliomas are molecularly complex neoplasms and require a multidisciplinary approach to treatment. Maximal safe resection is often the initial goal of treatment and extent of resection (EOR) is an important prognostic factor correlating with both progression-free-survival (PFS) and overall survival (OS). Postoperative patient outcome is also a critical and independent prognosticator and high EOR must not be achieved at the expense of good functional outcome. Several intraoperative adjuvant techniques have been developed to...
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Fluorescein-guided resection of gliomas.
Authors: Save AV, Gill BJ, D'amico RS, Canoll P, Bruce JN Abstract Standard of care in the management of high-grade gliomas includes gross total resection (GTR) followed by treatment with radiation and temozolomide. GTR remains one of the few independent prognostic factors for improved survival in this disease. Sodium fluorescein is an organic fluorophore that has been studied as a surgical adjunct to improve the likelihood of achieving GTR in gliomas. Though sodium fluorescein does not selectively accumulate in glioma cells, it allows for real-time identification of regions of blood brain barrier breakdown, corres...
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

"Dark corridors" in 5-ALA resection of high-grade gliomas: combining fluorescence-guided surgery and contrast-enhanced ultrasonography to better explore the surgical field.
CONCLUSIONS: When dark corridors are presents or when overlying brain parenchyma hinders illumination, drawbacks to the 5-ALA assistance can be expected, hence CEUS final survey has a crucial role of 'refinement'. In those selected cases, an integrated 5ALA+CEUS protocol was shown as advisable in EOR improvement. PMID: 31961118 [PubMed - in process] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Atypical presentation of meningioangiomatosis: it can bleed!
Authors: Lavalle L, D'elia A, Arcella A, Esposito V, Tufo T PMID: 31961119 [PubMed - in process] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - January 22, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

MicroRNA-98 promotes cell proliferation and invasion of glioblastoma via targeting HMGA2.
Authors: Wang B, Bu X, Sun H, Liu Y PMID: 31833733 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - December 15, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

MMP-9 and MMP-3 gene polymorphisms in neonatal hypoxic ischemic encephalopathy.
Authors: Li H, Yang M, Zhao Z, Zhou X, Liu Y, Zhuang Y, Shan Y PMID: 31833734 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - December 15, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Decompressive craniectomy and cranioplasty: the point of view of the neurorehabilitation team.
Authors: Formisano R, Contrada M, Colli G, Lombardi F PMID: 31738025 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Classification of orbitocranial wooden foreign body penetration injuries: what to do when they violate the intracranial space? A systematic review of the literature.
CONCLUSIONS: Grounded on our experience and on the review of the literature, we suggest, based on the anatomical localization of the OWF, a classification system for OWFs which is coupled with a tailored treatment strategy for each case. These suggestions are made to provide surgeons with direction on the correct management of such rare but challenging occurrences. PMID: 31738026 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Anatomical meningo-orbital band evaluation and clinical implications: a cadaveric dissection study.
CONCLUSIONS: In our study the average length of a safe incision of the MOB was 10.6 ± 1.1 mm. Thus, the incision length of the MOB should not exceed 9 mm; the peeling of the anterior cavernous sinus and of the SOF, dissecting the two layers of the dura throughout the incision of the MOB, is an useful technique to avoid cranial nerves and cavernous sinus lesions. PMID: 31738027 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.
CONCLUSIONS: Our studies demonstrated that GLO1 was highly expressed in glioma tissues and significantly correlated with the poor prognosis of glioma patients. It indicated that GLO1 might serve as a new prognostic predictor and therapeutic target for glioma treatment. PMID: 31738028 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Sexual discrimination in neurosurgery: a questionnaire-based nationwide study amongst women neurosurgeons in Bulgaria.
CONCLUSIONS: Although there is an ever increasing and growing awareness of the factors negatively impacting women progression in neurosurgery worldwide, there are still significant gaps and biases that hinder career progression amongst female neurosurgical communities and highlight a need for potential practices to be established in the workplace to counteract this. PMID: 31738029 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Correlation of MRI-detected vulnerable carotid plaques with clinical presentation: a systematic review and meta-analysis.
CONCLUSIONS: The presence of MRI-positive vulnerable carotid plaques including IPH, LRNC, and TRFC is positively associated with symptomatic clinical presentation. Therefore, carotid plaque MRI might be a useful risk stratification tool in determining the risk of ischemic stroke. PMID: 31738030 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

YNWA. You'll never walk alone.
Authors: Solari D, Somma T, De Divitiis O, Cavallo LM, Esposito F, D'avella E, Del Basso De Caro ML, Laws ER, Cappabianca P Abstract The technological advancements contributed to progressive improvement in patients' conditions and to their lives. In this scenario, it is important to underline the relevance of the multidisciplinary team approach, the impact played by women and a "third element": the non-profit associations of volunteers with solidarity purpose. Helping human as brothers and sisters makes one feel better, and represents the first chance for young people to interact with the adult world as d...
Source: Journal of Neurosurgical Sciences - November 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Development of cerebrospinal fluid fistula after incidental durotomy in spinal decompression surgery.
The objective of this study was to analyze the predictors for the development of CSF fistula after ID. METHODS: This retrospective study included 6024 consecutive patients who had been surgically treated for degenerative spinal disease at our clinic over the past 15 years. Patients who had undergone surgical revision for CSF fistula were assigned to the CSF fistula group. A matched 3:1 control group (ID group) was formed of patients with ID but without CSF fistula. Charts, surgical reports, and radiographic data were reviewed and statistically analyzed for demographics, duration of symptoms, co-morbidities, surgical st...
Source: Journal of Neurosurgical Sciences - November 5, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

From paradigm to paradox: divergency between intracranial pressure and intracranial pulse pressure during atmospheric pressure fall: a case study.
CONCLUSIONS: This study shows that increasing intracranial pressure is associated with its paradoxically decreasing amplitude under the influence of sudden and unexpected barometric pressure fall. This study suggests that abrupt changes in atmospheric pressure might impact intracranial pressure. PMID: 31680504 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 5, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Subarachnoid hemorrhage in the eighties: to treat or not to treat.
CONCLUSIONS: Elderly patients suffering from aneurysmal subarachnoid hemorrhage should be considered for treatment despite age, with endovascular embolization as the most preferable option. Without the treatment, the natural history can be very poor. PMID: 31680505 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 5, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

A minimally invasive approach for giant middle cerebral artery thrombosed aneurysms treatment.
CONCLUSIONS: Treatment of complex thrombosed MCA aneurysms is challenging. Side- to-side M2 anastomosis with the aim of transforming a bifurcation aneurysm in a sidewall aneurysm, suitable to be treated few days later by flow diverter deployment, offers a minimally invasive multimodal approach with the possibility of reducing serious complications. PMID: 31680506 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - November 5, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Q-ball - high resolution fiber tractography of language associated tracts-quantitative evaluation of applicability for glioma resections.
Authors: Becker D, Scherer M, Neher P, Jungk C, Jesser J, Pflüger I, Bendszus M, Meier-Hein K, Unterberg A Abstract BACKGROUND: To date, fiber tractography (FT) is predominantly based on Diffusion Tensor Imaging (DTI). High angular resolution diffusion imaging (HARDI)-based reconstructions have become a focus of interest, enabling the resolution of intravoxel fiber crossing. However, experience with high resolution tractography (HRFT) for neurosurgical applications is still limited to a few reports. This prospectively designed feasibility study shares our initial experience using an analytical q-ball approach ...
Source: Journal of Neurosurgical Sciences - November 5, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Posterior fossa endoscopy: a commentary.
Authors: Godano U Abstract PMID: 31601064 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 13, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

All-cause and tumor-specific mortality trends in elderly primary central nervous system lymphoma (PCNSL) patients: a surveillance, epidemiology, and end results (SEER) analysis.
Authors: Furst T, Hoffman H, Chin LS Abstract BACKGROUND: Recent primary central nervous system lymphoma (PCNSL) literature indicates that younger patients benefit from improved survival, however, this benefit is not shared by those 70+ years of age. The purpose of this study is to examine mortality trends in PCNSL patients 70+ years of age to better understand why improved prognosis has not yet reached this rapidly growing population subset. METHODS: 2075 cases (1973-2012, age at diagnosis 70+ years) within the Surveillance, Epidemiology, and End Results (SEER) database were included in Kaplan-Meier and multiv...
Source: Journal of Neurosurgical Sciences - October 13, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Chiari malformations: the impact of clinical and surgical features on a journal reviewer's evaluation protocol.
Authors: Visocchi M, Mattogno PP Abstract PMID: 31601066 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 13, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Invasiveness has no influence on the rate of incidental durotomies in surgery for multisegmental lumbar spinal canal stenosis ( ≥ 3 levels) with and without fusion. Analysis from the German Spine Registry data (DWG-Register).
CONCLUSIONS: The rate of incidental DT during decompression for LSS with and without fusion in ≥3 levels was associated with BMI and previous surgery at the same spinal level. Invasivness (SII) is valid rather for variables proper to surgery such as bledding and Op-time but no with incidence for DT and subsequent CSF-leackage. PMID: 31601067 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 13, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Microsurgical resection of trigone ventricular meningiomas using the parieto-occipital approach: a retrospective analysis of 47 cases and literature review.
Authors: Wang DP, He W, Shen XL, Hai J Abstract BACKGROUND: To investigate the risk factors of preoperative and postoperative treatment for trigone ventricular meningioma and the clinical efficacy of microsurgical resection of the neoplasm using the parieto-occipital approach. METHODS: Forty-seven trigone ventricular meningiomas were resected using the parieto-occipital approach in one institute from January 2015 to January 2019. Patients were postoperative followed up for 3 months to 3 years. Karnofsky Performance Status (KPS) and Glasgow Coma Scale (GCS) were used to assess patient's performance status and co...
Source: Journal of Neurosurgical Sciences - October 12, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Comparison between the different types of heterologous materials used in cranioplasty: a systematic review of the literature.
CONCLUSIONS: The ideal material for all heterologous cranioplasty has not yet been identified. The choice of material should be based on the clinical data of patients, such as the craniectomy size, presence of seizures, possibility of recovery, good long-term outcome associated with a cost analysis. PMID: 31599560 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 12, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Predicting endoscopic third ventriculostomy success in adult hydrocephalus: preliminary assessment of a modified ETV success score for adults (ETVSS-A) in a series of 47 patients.
CONCLUSIONS: From the results of this series, though small and retrospectively analyzed, it seems that ETVSS-A can be considered as a useful instrument to help neurosurgeon in predicting the ETV success and though define a more accurate surgical strategy in cases of hydrocephalus. Wider series and prospective studies are attended to validate these preliminary results. PMID: 31565904 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 2, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Association between pre-operative serum lactate concentrate with tumour cell proliferative index in primary brain tumour.
We describe the relationship between preoperative plasma lactate levels, and the cell proliferation marker Ki-67 in brain tumor surgery. METHODS: In this cross-sectional study, records of patients who underwent craniotomy between June 2017 and February 2018 at our Hospital were reviewed to select glioma and meningioma cases in which lactate concentrations in plasma and degree of cell proliferation were registered. Bivariable and linear regression analyses were used to assess the association between lactate concentrations and the Ki-67 index. RESULTS: Lactate concentrations in plasma and Ki-67 index were available i...
Source: Journal of Neurosurgical Sciences - October 2, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Intramedullary spinal cord tumors: the value of intraoperative neurophysiological monitoring in a series of 57 cases from two Italian centres.
We report a retrospective study from two Italian centres, in order to highlight the usefulness of IONM in the management of intramedullary lesions. METHODS: We performed a retrospective review of patients with intramedullary spinal tumor who underwent surgical resection from February 2011 to February 2018 in two different institutions. Clinical and radiological data, lesion features, timing of symptom onset and IONM findings were record ed . The IONM includ ed somatosensory-evoked potentials(SSEP), motor-evoked potentials(MEP) and D-Wave whenever possible. We evaluated the outcome according to the Modified McCormick sc...
Source: Journal of Neurosurgical Sciences - October 2, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Dexmedetomidine promotes spinal cord injury repairing via activating Nrf2/HO-1 signaling pathway.
Authors: Luo X, Chen T, Kang G, Zhao K, Qiu X, Yan L, Li M Abstract PMID: 31565907 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - October 2, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Microsurgery without microscope: a new generation of microsurgeons?
Authors: Fontanella MM, Belotti F, Fiorindi A Abstract PMID: 31486602 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - September 7, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

5-ALA fluorescence on tumors different from malignant gliomas. Review of the literature and our experience.
CONCLUSIONS: Due to the relatively few number or clinical studies, prospective clinical trials are needed to increase the overall level of evidence concerning the usage of 5-ALA in CNS tumors different from high-grade glioma. Furthermore, a greater us of new tools such as, spectroscopy or confocal microscope or the use of combination of other fluorescence could make more effective this technique. PMID: 31355622 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - July 31, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Supramarginal resection of glioblastoma: 5-ALA fluorescence, combined intraoperative strategies and correlation with survival.
Authors: Certo F, Stummer W, Farah JO, Freyschlag C, Visocchi M, Morrone A, Altieri R, Toccaceli G, Peschillo S, Thomè C, Jenkinson M, Barbagallo G Abstract Glioblastoma treatment requires a multidisciplinary approach involving oncologists, radiotherapists and surgeons. Surgery constitutes the initial step of the therapeutic strategy and its efficacy is dependent on the extent of resection (EOR). Over the last decade, the goal of surgical treatment was the resection of the contrast enhancement on T1 MRI, defined as gross-total resection (GTR). More recently, an increasing number of studies reports a positive...
Source: Journal of Neurosurgical Sciences - July 31, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research